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High FSHR expression is associated with polycystic ovary syndrome.
The paper reviews the data concerning the appearance of ectopic FSHR in particular human neoplasms. The possible involvement of FSHR in tumor progression and the use of FSHR for diagnostic/therapeutic purposes is also reviewed.
FSHR rs6165, not ESR2 (show ESR2 Proteins) rs4986938, could be suggested as a candidate marker to predict poor ovarian response.
The frequency of alleles and genotypes of polymorphisms FSHR(-29G/A) and ESRI (XbaI A/G) in women with normal to poor response did not have significant correlation.
Data provide evidence that FSHR expression is regulated by BDNF (show BDNF Proteins) which affects its expression and post-translational modifications in granulosa cells.
we observed that a genetic variant associated with FSHR activity may modulate the susceptibility to testicular germ cell cancer
The results herein suggest that the FSHR polymorphism N680S is significantly associated with preterm birth in a Mexican-Mestizo population.
FSHR single nucleotide polymorphism is associated with poor ovarian response in Egyptian women undergoing IVF (show SCN5A Proteins) procedure.
Findings suggest that 680Ser-Ser (show SIGLEC1 Proteins)/GG genotype and "GG/307Ala680Ser" haplotype increase the risk of endometriosis in fertile women, while "GA/307Ala680Asn" haplotype decreases the risk of endometriosis development and progression.
The FSHR -29G/A polymorphism modulates FSH (show BRD2 Proteins) and, for the first time, LH serum levels and body mass index in normozoospermic men.
The amount of dopamine d1 receptor (show DRD1 Proteins), dopamine D2 receptor (show DRD2 Proteins), and follicle stimulating hormone receptor (FSHr) mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.
Activated TGF-beta (show TGFB1 Proteins) signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.
The results showed that polymorphisms in exon 10 of the FSHR gene had a significant effect on litter size traits of Wannan Black and Berkshire pigs. These results can be applied for marker-assisted selection in the 2 swine breeds
These results showed that an increased FSHR gene expression level was accompanied with an increase in histone H3K9 acetylation levels, suggesting that histone H3K9 acetylation could regulate the expression of the porcine FSHR gene.
248 F(2) animals from a Duroc and Meishan cross were genotyped for three FSHR SNPs at positions 74, 532 and 1166, and these were correlated with the phenotypes of litter size and corpus luteum number
findings suggest the FSH receptor may be involved in the early follicle formation in pigs, which begins during prenatal life.
These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A (show IL1A Proteins) and Fshr expression.
Mouse chondrocytes and human articular cartilage express functional FSHR. Moreover, FSH (show BRD2 Proteins) can act on chondrocytes and cause genetic changes.
Study demonstrates expression of follicle-stimulating hormone receptor (FSHR) and a direct action of follicle-stimulating hormone on testicular stem/germ cells possibly mediated via alternatively spliced growth factor type 1 receptor FSHR3 in mice.
FSHR and LHR (show LHCGR Proteins) proteins are significantly upregulated in CCs (show CCS Proteins) surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence.
Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1 (show ESR1 Proteins), LHR (show LHCGR Proteins), and FSHR
Brca1 (show BRCA1 Proteins)(GC-/-) models reveal that specific intra-follicular Brca1 (show BRCA1 Proteins) loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Proteins) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.
Data (including date from knockout mice) suggest that Fshr is expressed early in pregnany in placenta and other extragonadal tissues of fetoplacental unit; expression is particularly strong at term.
Sertoli cell-specific expression of MTA2 (show MTA2 Proteins) is required for transcriptional regulation of FSHR gene during spermatogenesis.
By day 20 and in adult animals total AR or FSHR ablation significantly reduced Leydig cell numbers but Sertoli cell specific AR ablation had no effect.
The results demonstrate that gain-of-function mutations of the FSHR in mice bring about distinct and clear changes in ovarian function
INVESTIGATION OF STAT5A (show STAT5A Proteins), FSHR AND LHR (show LHCGR Proteins) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts.
transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
This study evaluated the relationships among aromatase (show CYP19A1 Proteins), IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and follicle stimulating hormone (FSH) receptor levels expressed in ovarian follicles of cattle selected for twin pregnancies.
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r (show IGF1R Proteins), and p450 arom (show CYP19A1 Proteins) expression, and precedes induction and subsequent peak E2 production
Dominant follicles experience a reduction in FSH (show BRD2 Proteins) dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR (show LHCGR Proteins)) as they grow during the low FSH (show BRD2 Proteins) milieu of follicular waves.
FSHR is specifically regulated through androgen receptor (show AR Proteins) in granulosa cells
Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR (show LHCGR Proteins) and FSHR genes, respectively), but no significant effects were observed for the genes studied (
Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr (show LHCGR Proteins)) resulted in infertile males.
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr (show LHCGR Proteins).
Characterization of the first functional zebrafish (Danio rerio) gonadotropic hormone I receptor (follicle stimulating hormone receptor).
FSHR is expressed in the hamster ovary starting from the fetal life to account for FSH (show BRD2 Proteins)-induced primordial follicle formation and cyclic AMP (show TMPRSS5 Proteins) production.
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
, follicle-stimulating hormone receptor
, follitropin receptor
, follicle stimulating hormone receptor
, gonadotropic hormone I
, follicle-stimulating hormone receptor-like