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Human Polyclonal HDAC6 Primary Antibody for IHC, WB - ABIN223301
Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody for ChIP, WB - ABIN2668292
Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. in PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody for IHC (p), WB - ABIN387955
Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 6 Pubmed References
Human Polyclonal HDAC6 Primary Antibody for ELISA - ABIN564313
Xargay-Torrent, López-Guerra, Saborit-Villarroya, Rosich, Campo, Roué, Colomer: Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Monoclonal HDAC6 Primary Antibody for ELISA, WB - ABIN564314
Bantscheff, Hopf, Savitski, Dittmann, Grandi, Michon, Schlegl, Abraham, Becher, Bergamini, Boesche, Delling, Dümpelfeld, Eberhard, Huthmacher, Mathieson, Poeckel, Reader, Strunk, Sweetman, Kruse et al.: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. ... in Nature biotechnology 2011
Human Polyclonal HDAC6 Primary Antibody for ChIP, IP - ABIN4316760
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Human Monoclonal HDAC6 Primary Antibody for FACS, ICC - ABIN4316769
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2 (show PLIN2 Antibodies)
HDAC6 is necessary and sufficient for BRP (show GDF5 Antibodies) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (show TUBA4A Antibodies) proteostasis and disruption of the cardiomyocyte microtubule structure.
From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy
Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.
Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (show EHMT2 Antibodies) to modify histone H3K9 and to determine cell fates.
Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
HDAC6 inhibition and the regulation of Prx1 (show PRRX1 Antibodies) activity may play a significant role in protecting retinal cells and in particular photoreceptors.
DTBP (show TBP Antibodies) represents a promising lead structure for the development of HDAC6 inhibitors, with an improvement in specificity conferred by modification of the cap group. We propose for the first time that the underlying mechanism of the anticancer activity of DTBP (show TBP Antibodies) is attributed to inhibition of HDAC6 activity.
To the best of our knowledge, this is the first report of an HDAC6 selective inhibitor bearing a hydrazide ZBG. Its capability to passively cross the blood-brain barrier (BBB (show ALMS1 Antibodies)), as observed through PAMPA assays, and its low cytotoxicity in vitro, suggested its potential for drug development.
we observed an homologous-recombination deficiency (HRD)-associated level of HDAC6 overexpression, which supports a potential role for the effectiveness of HDAC inhibitor treatment in HRD tumors that are characterized by low levels of H4 lysine acetylation.
High expression of HDAC6 is associated with chondrosarcoma.
HDAC6, a primarily cytoplasmic deacetylase, mediates TGF-beta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) in human lung cancer cells via activation of Notch1 (show NOTCH1 Antibodies).
Results confirm histone deacetylase 9 (HDAC9 (show HDAC9 Antibodies)) as a major risk gene for large artery stroke with an association in the 3'-UTR (show UTS2R Antibodies).
deletion or inhibition of the cytoplasmic shuttling factor HDAC6 suppressed neuritic tau bead formation in neurons.
At the recommended phase II dose of ricolinostat of 160 mg daily, the combination with bortezomib and dexamethasone is safe, well-tolerated, and active, suggesting that selective inhibition of HDAC6 is a promising approach to multiple myeloma therapy.
Increased HDAC6 expression is associated with renal cell carcinoma (show MOK Antibodies).
Our work shows that RanBPM, together with the CTLH complex, associates with HDAC6 and restricts cell migration through inhibition of HDAC6 activity. This study uncovers a novel function for the CTLH complex and suggests that it could have a tumour suppressive role in restricting HDAC6 oncogenic properties.
overexpression of Hdac6 extends reproductive lifespan in mice
Hdac6-/- mice display low serum levels of inflammatory cytokine IL-6 (show IL6 Antibodies) and correspondingly an increased survival to a systemic infection with Listeria monocytogenes. The impaired bacterial clearance in the absence of HDAC6 appears to be caused by a defect in autophagy.
HDAC6 inhibition and the regulation of Prx1 (show PRDX1 Antibodies) activity may play a significant role in protecting retinal cells and in particular photoreceptors.
Results link the aberrant GlyRS (show GARS Antibodies)-HDAC6 interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 as an effective therapeutic target.
3T3-L1 cells treated with the siRNA against HDAC6 reduced the autophagy level and enhanced collagen-induced cilia elongation, implying that HDAC6 was involved in mediating autophagy
identified that class II histone deacetylase 6 deacetylates and subsequently activates mDia2 (show DIAPH3 Antibodies).
Study demonstrated that global Hdac6 knock-out mice show dopaminergic abnormalities. The behavioral and pharmacological analysis revealed that Hdac6 gene ablation results in an increased response of postsynaptic D2R (show DRD2 Antibodies).
Findings provide physiological insight into the ciliary role of the CYLD (show CYLD Antibodies)/HDAC6 axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
Suppression of HDAC6 enhanced the interaction between HIF-1alpha (show HIF1A Antibodies) and HSP70 (show HSP70 Antibodies) under hypoxic conditions.
In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt and activated glycogen synthase kinase (GSK)-3beta.
the histone deacetylase HDA6 can interact with the histone methyltransferases SUVH4, SUVH5, and SUVH6 (SUVH4/5/6).
HDA6 is a general repressor of pathogen defence response and plays important roles in inhibiting and modulating the expression of pathogen-responsive genes in Arabidopsis.
The hda6 mutant showed a BR-repressed phenotype in the dark and was less sensitive to BR biosynthesis inhibitors. Genetic analysis indicated that HDA6 regulates BR signaling through BIN2. Furthermore, we identified K189 of BIN2 as an acetylated site, which can be deacetylated by HDA6 to influence BIN2 activity
The results suggest that HSI2 recruits MED13 (show MED13 Antibodies) and HDA6 to suppress directly a subset of seed maturation genes post-germination.
HDA6 is a component of the TRB2 (show TRIB2 Antibodies) complex.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (show HELLS Antibodies) at CG dinucleotides.
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (show CD86 Antibodies)) in the root tip were affected in hda6 mutation.
HDC1 is a ubiquitously expressed nuclear protein (show UBN1 Antibodies) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA6 and FLD (show LPIN1 Antibodies) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (show MBD2 Antibodies) through HDA6 and FLD (show LPIN1 Antibodies) interaction in flowering control.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
, histone deacetylase 6
, histone deacetylase HDA2
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6