Rat IgG2b,kappa Isotype Control

Details for Product No. ABIN2656467, Supplier: Log in to see
Clonality (Clone)
Monoclonal ()
Isotype Control (IsoC), Western Blotting (WB)
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Supplier Product No.
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Clone RTK4530
Isotype IgG2b kappa
Characteristics The isotype of RTK4530 immunoglobulin is rat IgG2b, κ. This antibody was chosen as an isotype control after screening on a variety of resting, activated, live, and fixed mouse, rat and human tissues.
Purification The immunoglobulin was purified by affinity chromatography, and conjugated with PerCP under optimal conditions. The solution is free of unconjugated PerCP and unconjugated immunoglobulin.
Alternative Name IgG2b kappa
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Background publications Schaefer, Montufar-Solis, Vigneswaran, Klein: "ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice." in: Journal of leukocyte biology, Vol. 87, Issue 2, pp. 301-8, 2010 (PubMed).

Yi, Yu, Gao, Wang, Baek, Chen, Kim, Subjeck, Wang: "Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation." in: Blood, Vol. 113, Issue 23, pp. 5819-28, 2009 (PubMed).

Duan, Avci, Kasper: "Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 13, pp. 5183-8, 2008 (PubMed).

Sasaki, Zhao, Pardee, Ueda, Fujita, Sehra, Kaplan, Kane, Okada, Storkus: "Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 1, pp. 104-8, 2008 (PubMed).

Cervantes-Barragan, Züst, Weber, Spiegel, Lang, Akira, Thiel, Ludewig: "Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon." in: Blood, Vol. 109, Issue 3, pp. 1131-7, 2007 (PubMed).

Zeiser, Nguyen, Hou, Beilhack, Zambricki, Buess, Contag, Negrin: "Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease." in: Blood, Vol. 109, Issue 5, pp. 2225-33, 2007 (PubMed).