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Human IFNA Protein expressed in Escherichia coli (E. coli) - ABIN803851
Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: Gender specificity of altered human immune cytokine profiles in aging. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
excessive IFN-alpha perturbs glycosphingolipids metabolism in B cells which in turn adversely affects iNKT homeostasis
These findings suggest that IFN-a can inhibit HCV replication through a STAT2-dependent but STAT1-independent pathway, whereas IFN-g induces ISG expression and inhibits HCV replication exclusively through a STAT1- and STAT2-dependent pathway.
Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment
this study demonstrated for the first time that IFNalpha elicits endoplasmic reticulum stress in human beta cells providing a novel mechanistic role for this virus-induced cytokine in the development of Type 1 Diabetes
the expression of certain TAM components was reduced as a result of prolonged degradation of MYD88 by Porphyromonas gingivalis infection.
The TBK1 Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1.
the results documented here suggest an inhibitory role for the early-secreted IFNalpha on specific responses to Bordetella pertussis infection, as well as facilitating early pulmonary colonization with B. pertussis in mice
this study introduces a novel pathway by which IFN-alpha serves as a proatherogenic mediator through repression of eNOS-dependent pathways
study reports that mitochondrial antiviral signaling protein (MAVS), -mediated IFN-alpha/beta production and IFNAR signaling are required for alloimmune responses to the human K1 Ag in a murine model of inflammation-induced alloimmunization
CD169(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8(+) T-cell exhaustion and immunopathology.
These results suggest that pulmonary C-fibers affect IFNGR1 expression by inducing IFN-alpha to regulate IFN-gamma-mediated airway inflammation and airway hyperresponsiveness.
results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8(+) T cell response
STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site.
In the exorbital lachrymal gland, the mRNA expression of IFN beta and IFN alpha (type I IFNs) was weak- to strong-positive at 1 days post inoculation (DPI), and became negative at 2DPI.
The authors conclude that IFN-alphabeta is pathogenic during chronic Mycobacterium africanum infection and that the pathogenic effects may be mediated through poorer control of bacterial growth.
IRF-1 and interferon-alpha with interferon-beta cooperate to control acute gammaherpesvirus infection.
APOBEC3 can restrict retroviruses in a type I interferon-independent manner in vivo. By contrast, the ability of APOBEC3 to promote neutralizing antibody responses is type I interferon-dependent.
We concluded that the vulnerability of plaques was associated with the activation of IFN-I in pristane-treated ApoE(-/-) mice
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes
Thus, despite their use of the same receptor, IFNbeta and IFNalpha have unique and distinguishable biologic functions, with IFNbeta being mainly responsible for promoting lymphocytic choriomeningitis virus persistence.
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted.