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Gene therapy with plasmids encoding IFN-beta (show IFNB1 Proteins) and -alpha14, but not the commonly used -alpha2, confers long-term suppression of HIV-1 replication.
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Produced by macrophages, IFN-alpha have antiviral protein kinase and an oligoadenylate synthetase.
interferon, alpha 14
, interferon alpha-H
, interferon alpha-14
, interferon lambda-2-H
, leIF H