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anti-Human IFNA2 Antibodies:
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Human Monoclonal IFNA2 Primary Antibody for FACS, IF - ABIN5580529
Kontsek, Borecky, Kontsekova, Macikova, Kolcunova, Novak, Krchnak: Mapping of two immunodominant structures on human interferon alpha 2c and their role in binding to cells. in Molecular immunology 1992
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Human Monoclonal IFNA2 Primary Antibody for FACS, IF - ABIN5580531
Pestka, Langer, Zoon, Samuel: Interferons and their actions. in Annual review of biochemistry 1987
IFNa and IFNc show similar antiviral activities and ability to induce antiviral genes in lymphoid tissues.
Data indicate that the combination of AAV2.IL-4 (show IL4 Antibodies) and AAV2.IFN-alpha was not significantly different as compared to AAV2.IL-4 (show IL4 Antibodies) alone.
Infecting virus and the target cell type dictate the extent and signature of inducible IFN-alpha2 gene expression.
Mutation of the IFNAR-1 (show IFNAR1 Antibodies) receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.
produced in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus in lymph nodes cells expressing the myeloid markers CD14 (show CD14 Antibodies), CD11b (show ITGAM Antibodies), and CD172a (show SIRPA Antibodies)
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Antibodies) and, to a lesser extent, STAT2 (show STAT2 Antibodies).
These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR (show IFNAR1 Antibodies) endosomal sorting and a new factor in type-I IFN-induced JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signalling and gene transcription.
PVT1 interacts with STAT1 to inhibit IFN-alpha signaling and tumor cells proliferation.
Here, we investigated the molecular signals induced by ARI (show ARIH1 Antibodies)(azacytidine (A) and romidepsin (R), with IFNalpha2 ) treatment and found that this drug combination increased the accessibility to regulatory sequences of IFN-stimulated genes and IFN transcription regulatory factors that were epigenetically silenced in both colorectal cancer cells and Dendritic Cells.
All the tested TLRAs induced greater infant IFN-alpha2 production compared to newborn and adult blood. In contrast, CpG induced greater IFN-gamma (show IFNG Antibodies), IL-1beta (show IL1B Antibodies), IL-4 (show IL4 Antibodies), IL-12p40, IL-10 (show IL10 Antibodies) and CXCL8 (show IL8 Antibodies) in newborn than in infant and adult blood.
Interferon-alpha-induced CD100 (show SEMA4D Antibodies) expression on naive CD8 (show CD8A Antibodies)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 (show CD72 Antibodies) signal transduction.
Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function on exposure to IFN-alpha2a and IFN-gamma (show IFNG Antibodies).
Increase in serum IFNA2 is associated with adenoma.
Data suggest IFNA2 binding to extracellular domain of IFN receptors IFNAR1 (show IFNAR1 Antibodies) or IFNAR2 (show IFNAR2 Antibodies) promotes proximity between intracellular domains; signaling depends on duration of activation and affinity of binding rather than specific conformational changes.
Report biased expression of human interferon alpha-2b and Escherichia coli methionine amino peptidase genes under control of single promoter in E. coli.
interferon alpha-2b gene mutations were identified among brain tumor patients; highest percentage of frameshift mutations was identified; patients were found to be under environmental stress from contaminated drinking water and from local gamma radiations
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold.
, alpha-2a interferon
, interferon alpha 2a
, interferon alpha 2b
, interferon alpha A
, interferon alpha-2
, leIF A
, interferon alpha family, gene 2
, interferon alpha 2
, IFN-alpha 2
, interferon-alpha 2