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Mouse (Murine) IFNA2 Protein expressed in Human Cells - ABIN2007923
Xiao, Xiao, Xu, Wang, Chen, Liu, Li, Shi, Nie, Li, Wu, Liu, Ren, Guleng: Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients. in Scientific reports 2015
IFNa (show IFNA Proteins) and IFNc show similar antiviral activities and ability to induce antiviral genes in lymphoid tissues.
Data indicate that the combination of AAV2.IL-4 (show IL4 Proteins) and AAV2.IFN-alpha (show IFNA Proteins) was not significantly different as compared to AAV2.IL-4 (show IL4 Proteins) alone.
Infecting virus and the target cell type dictate the extent and signature of inducible IFN-alpha2 gene expression.
Mutation of the IFNAR-1 (show IFNAR1 Proteins) receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.
produced in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus in lymph nodes cells expressing the myeloid markers CD14 (show CD14 Proteins), CD11b (show ITGAM Proteins), and CD172a (show SIRPA Proteins)
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Proteins) and, to a lesser extent, STAT2 (show STAT2 Proteins).
These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR (show IFNAR1 Proteins) endosomal sorting and a new factor in type-I IFN-induced JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signalling and gene transcription.
PVT1 interacts with STAT1 (show STAT1 Proteins) to inhibit IFN-alpha (show IFNA Proteins) signaling and tumor cells proliferation.
Here, we investigated the molecular signals induced by ARI(azacytidine (A) and romidepsin (R), with IFNalpha2 ) treatment and found that this drug combination increased the accessibility to regulatory sequences of IFN-stimulated genes and IFN transcription regulatory factors that were epigenetically silenced in both colorectal cancer cells and Dendritic Cells.
All the tested TLRAs induced greater infant IFN-alpha2 production compared to newborn and adult blood. In contrast, CpG induced greater IFN-gamma (show IFNG Proteins), IL-1beta (show IL1B Proteins), IL-4 (show IL4 Proteins), IL-12p40, IL-10 (show IL10 Proteins) and CXCL8 (show IL8 Proteins) in newborn than in infant and adult blood.
Interferon-alpha (show IFNA Proteins)-induced CD100 (show SEMA4D Proteins) expression on naive CD8 (show CD8A Proteins)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 (show CD72 Proteins) signal transduction.
Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function on exposure to IFN-alpha2a and IFN-gamma (show IFNG Proteins).
Increase in serum IFNA2 is associated with adenoma.
Data suggest IFNA2 binding to extracellular domain of IFN receptors IFNAR1 (show IFNAR1 Proteins) or IFNAR2 (show IFNAR2 Proteins) promotes proximity between intracellular domains; signaling depends on duration of activation and affinity of binding rather than specific conformational changes.
Report biased expression of human interferon alpha-2b and Escherichia coli methionine amino peptidase genes under control of single promoter in E. coli.
interferon alpha-2b gene mutations were identified among brain tumor patients; highest percentage of frameshift mutations was identified; patients were found to be under environmental stress from contaminated drinking water and from local gamma radiations
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold.
, interferon alpha 2
, interferon alpha family, gene 2
, interferon alpha A
, IFN-alpha 2
, interferon-alpha 2
, alpha-2a interferon
, interferon alpha 2a
, interferon alpha 2b
, leIF A