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anti-Mouse (Murine) IL-3 Antibodies:
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Mouse (Murine) Monoclonal IL-3 Primary Antibody for Inhibition, Neut - ABIN2689758
Abrams: Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. in Current protocols in immunology / edited by John E. Coligan ... [et al.] 2008
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Mouse (Murine) Monoclonal IL-3 Primary Antibody for ELISA, WB - ABIN2689759
Abrams, Pearce: Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro. in Journal of immunology (Baltimore, Md. : 1950) 1988
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Mouse (Murine) Monoclonal IL-3 Primary Antibody for FACS, Neut - ABIN1177293
Weinstein, Ihle, Lavu, Reddy: Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line. in Proceedings of the National Academy of Sciences of the United States of America 1986
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Human Monoclonal IL-3 Primary Antibody for ELISA - ABIN2689760
Abrams, Roncarolo, Yssel, Andersson, Gleich, Silver: Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. in Immunological reviews 1992
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Human Polyclonal IL-3 Primary Antibody for ELISA, WB - ABIN1043802
Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: New genetic associations detected in a host response study to hepatitis B vaccine. in Genes and immunity 2010
Jak1-deficient hematopoietic stem cells exhibit increased quiescence, an inability to enter the cell cycle in response to hematopoietic stress, and a marked reduction in cytokine sensing, including in response to type I interferons and IL-3.
findings indicate that STAT5 contributes to the remarkable IL-3-mediated inhibition of RANKL-induced osteoclastogenesis by activating Id genes and their associated pathways.
c-Kit(+) Adipose tissue-derived mesenchymal stem cells (ASCs)may promote breast cancer growth and angiogenesis by a synergistic effect of c-Kit and IL-3. Our findings suggest that c-Kit(+) subpopulations of ASCs should be eliminated in fat grafts for breast reconstruction of cancer patients following mastectomy.
These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia.
IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Thus, IL-3 plays an important role in the pathogenesis of SLE and the progression of lupus nephritis.
Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Stem cell factor (SCF), but not interleukin-3 (IL-3), is a major effector of HSC maturation during embryonic day E9-E10.
study reports IL3 potentiates inflammation in sepsis; in model of abdominal sepsis, findings show innate response activator B cells produce IL3, which induces myelopoiesis of monocytes and neutrophils and fuels cytokine storm; IL3 deficiency protects against sepsis
these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages.
Altered expression of CD30L and IL-3 may be potential biomarkers for hepatotoxicity induced by D. bulbifera.
This study is the first to link beta-catenin activation to IL-3 and suggests that targeting IL-3 signaling may be an effective approach for the inhibition of beta-catenin activity in some patients with AML.
IL-3 plays a critical role in suppressing protective immunity to P. berghei NK65 infection.
IL-3 promotes Stat5 activation in osteoclasts.
these findings not only provide a better understanding of the role of IL-3 in osteoclastogenesis but may also facilitate future studies to delineate the role of IL-3 in the pathogenesis of bone diseases.
Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3.
At day 10, CIP treatment not only significantly reduced pro-inflammatory cytokine and chemokine concentrations, including interleukin-6 (IL-6) and KC, but it also enhanced IL-3 production compared to vehicle-treated controls.
IL-3 upregulates Trib3 mRNA expression in bone-marrow-derived mast cells. During prolonged IL-3 starvation, cell death is accelerated in Trib3-null cultures.
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
IL-3 may be involved in the immediate memory deficits in the chronic phase of schizophrenia.
The present study demonstrates for the first time that IL-3 has an important role in enhancing the migration of human MSCs through regulation of the CXCR4/SDF-1alpha axis. These findings suggest a potential role of IL-3 in improving the efficacy of MSCs in regenerative cell therapy.
These results indicate that IL-3 regulates endothelial cells-extracellular vesicles release, cargo and IL-3 angiogenic paracrine action via STAT5.
T-GM-CSF and -IL-3 significantly, and reciprocally, blunted receptor binding and myeloid progenitor cell proliferation activity of both FL-GM-CSF and -IL-3 in vitro and in vivo
Results show that IL-3 induces several signaling pathways associated with increased cell survival under oxidative stress. This activity correlates with previous fi ndings indicating glucose uptake stimulation by IL-3, which together contribute to an emerging picture of a broader mechanism promoting cell survival.
The IL-3/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models
IL-3 hardly down-regulates the alpha-chain of its receptor without depleting the common beta-chain, which enables extraordinarily sustained signaling events, predominantly the activation of Stat5.
genetic polymorphisms in the immune genes IL-3 rs181781 and CTLA4 rs4553808 may influence the TAC dose-adjusted concentrations
Our results indicated that the IL-3 and IL-13 polymorphisms were not associated with rheumatoid arthritis (RA). stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) <25.00. these findings suggest that the IL-13 rs1800925 C/T polymorphism may be associated with increased risk of RA in ESR
results suggest that IL-3 and IL-12p40 could be considered as molecular predictors for recurrent wheezing due to RSV infection
results suggest that IL3 is an important genetic regulator for human brain volume variation and implied that IL3 might have experienced weak or modest positive selection in the evolutionary history of humans
Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent
were not able to confirm the association of IL-3 SNPs with schizophrenia.
findings showed that high plasma IL-3 levels are associated with high mortality in sepsis
Genetic variation in interleukin-3 gene is associated with breast cancer risk.
results suggest that HuR recognizes the ARE-rich region in the IL-3 3'-UTR and plays a role in the IL-3 3'-UTR-mediated post-transcriptional control in T-cells
A single nucleotide polymorphism (SNP; rs20541) in the IL-13 gene has been recognized as a risk factor for asthma.
IL3 SNP rs40401 is significantly associated with the risk of asthma in young adult Japanese women.
cytokine that functions as a multi-lineage haemopoietic growth regulator
, hematopoietic growth factor
, mast cell growth factor
, multipotential colony-stimulating factor
, P-cell stimulating factor
, mast-cell growth factor
, multilineage-colony-stimulating factor
, colony-stimulating factor, multiple
, Hematopoietic growth factor
, Mast cell growth factor
, Multipotential colony-stimulating factor