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Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305061
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993
Show all 5 Pubmed References
Mouse (Murine) IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1305060
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
Show all 4 Pubmed References
Human IL12B Protein expressed in Human Cells - ABIN2648866
Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. in Nature immunology 2015
Study confirms an association between IL12B and IL23R (show IL23R Proteins) genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles).
IL-12 (show IL12A Proteins) B gene AA genotype presented more frequently in late stages of Hepatitis C virus chronically ill patients, while, CC genotype had no significant association with staging of liver disease and had low frequency especially in late stages of liver disease.
IL-12 (show IL12A Proteins) receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation.
Frequency of IL-12B AA (rs6871626) genotype was increased in Ankylosing Spondylitis patients. Interleukin IL-12B AA (rs6871626) gene polymorphisms could serve as promising biomarkers for diagnosis and prognosis in Ankylosing Spondylitis patients.
The demonstrated allelic expression imbalance supports the idea that the IL12B risk haplotype confers susceptibility not only to Crohn's disease onset but to also relapse through increased IL12B mRNA expression.
the present study IL-12B gene status was evaluated in 50 new sputum smear-positive pulmonary tuberculosis patients.
The rs17860508 polymorphism in the IL12B promoter region may influence the risk of developing ovarian endometriosis by altering the endometrial expression of IL12B of in Northern Chinese women.
In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10 (show IL10 Proteins)) rs1800872, IL-12 (show IL12A Proteins) rs3212227 and tumor necrosis factor-(TNF-alpha (show TNF Proteins)) rs1800629 polymorphism in osteonecrosis of the femoral head (ONFH). IL-12 (show IL12A Proteins) rs3212227 AC genotype confer genetically susceptibility to ONFH in the Chinese Han population.
The rs6871626 single nucleotide polymorphism in IL-12B is associated with the pathophysiology of Takayasu arteritis.
INSR (show INSR Proteins) rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B, CCND1 (show CCND1 Proteins) and IL10 (show IL10 Proteins) genes are not linked with the presence of gastric cancer
In macrophages, SCIMP (show SCIMP Proteins) is constitutively associated with the Lyn (show LYN Proteins) tyrosine kinase (show TYRO3 Proteins), is required for tyrosine phosphorylation of TLR4 (show TLR4 Proteins), and facilitates TLR-inducible production of the IL-6 (show IL6 Proteins) and IL-12p40.
Results show the overproduction of IL-12 (show IL12A Proteins)/23p40 in dendritic cells, leading to Th1 (show HAND1 Proteins) and Th17 programs in a mouse model of Yersinia enterocolitica-induced reactive arthritis.
this study demonstrates that regulation of IL-12p40 by hypoxia-inducible factor-1alpha controls Th1 (show HAND1 Proteins)/Th17 responses to prevent mucosal inflammation
the nuclear localized CA-VI (show CA6 Proteins) B selectively promotes IL-12 (show IL12A Proteins) expression by interaction with protein arginine N-methyltransferase 5 (PRMT5 (show PRMT5 Proteins)), which reduces symmetric dimethylation of histone H3 (show HIST3H3 Proteins) arginine 8 modification (H3R8me2s) at Il12 (show IL12A Proteins) promoters to facilitate chromatin accessibility, selectively enhancing c-Rel (show NFkBP65 Proteins) binding to the Il12b promoter.
The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 (show IL12A Proteins) plays important roles in inhibiting pathological retinal neovascularization.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
this study shows that a systemic IL-12 (show IL12A Proteins) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (show IL12A Proteins) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6 (show IL6 Proteins), IL-12 (show IL12A Proteins)]
study investigated hypothesis that CD40 (show CD40 Proteins) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (show NOS2 Proteins) and IL-12p40 genes downstream of p38 (show MAPK14 Proteins)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Proteins)/8 and TLR-9 (show TLR9 Proteins) stimulation, which could potentially affect their response to vaccination and viral infection.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta