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anti-Mouse (Murine) Serotonin Receptor 1A Antibodies:
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Human Polyclonal Serotonin Receptor 1A Primary Antibody for WB - ABIN2792271
Czesak, Lemonde, Peterson, Rogaeva, Albert: Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 6 Pubmed References
Guinea Pig Polyclonal Serotonin Receptor 1A Primary Antibody for IEM, ICC - ABIN617930
Chalazonitis, Pham, Li, Roman, Guha, Gomes, Kan, Kessler, Gershon: Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. in The Journal of comparative neurology 2008
Show all 4 Pubmed References
Human Polyclonal Serotonin Receptor 1A Primary Antibody for IF (p), IHC (p) - ABIN738006
Yeh, Weng, Chang, Chan, Huang, Chu, Wei, Ma, Cheng, Ma, Chen, Shyu: Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016
Show all 2 Pubmed References
Human Polyclonal Serotonin Receptor 1A Primary Antibody for ELISA, IHC (p) - ABIN6259651
Sun, Xu, Yi, Chen, Wu, Cao, Zhou, Jiang, Zhang: Role of 5-HT1A receptor in insular cortex mediating stress - induced visceral sensory dysfunction. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2018
Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin signaling
Decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss in temporal lobe epilepsy.
The Drosophila serotonin receptor 1A has a role in promoting baseline sleep.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(1A)-like receptors with 8-OH-DPAT increases overall aggression; 5-HT(1A)-like receptor manipulation primarily affects wing threats and fencing
5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
role of cholesterol in solubilization of G-protein-coupled serotonin 1A receptors
ligand binding function of the 5-HT(1A) receptor is a cholesterol-dependent phenomenon that is not related to the ability of cholesterol to modulate membrane order
Increased levels of 5-HT1A receptor binding were seen in the raphe nuclei following chronic ethanol self-administration.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
Significantly lower 5-HT1A binding is found in s-carrier subjects (5-HTTLPR genotype) in both cortical brain regions and the raphe nuclei.
5-HT1A receptor levels increase during development in the female brain from pre-to peripuberty.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(1A), SST(1), and SST(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Since the 5-HT(1A) and 5-HT(2) agonists decreased and increased, respectively, the duration of TI, different serotonin receptor subtypes may play distinct roles in the modulation of TI in the guinea pig.
5-HT1AR KO affected anxiety in male mice, and fear memory and prepulse inhibition in female mice. 5-HT1AR genotype moderated the effects of maternal prenatal stress exposure on social behavior of male offspring and on activity levels of female offspring. Findings indicate that 5-HT1A receptor availability affect outcomes of the offspring resulting from maternal prenatal stress exposure sex-specifically.
Under basal conditions, 5-HT1AR overexpressing animals presented high corticosterone levels and a lower mineralocorticoid/glucocorticoid receptor ratio. After pre-exposure to a single stressor, they showed a high anxiety-like response, a blunted increase in corticosterone levels, higher prefrontal c-Fos activation, and lack of downregulation of hippocampal long-term potentiation.
Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor in modulating anxiety-related behaviors.
activation of the 5-HT1A receptor during the postnatal period may reduce anxiety levels, but increase depression levels during adulthood via different multiple molecules in the mPFC and ventral hippocampus.
Zn can modulate both presynaptic and postsynaptic 5-HT1ARs.
5-HT1A autoreceptor expression in serotonin neurons requires Freud-1 and is linked to anxiety/depression-like behavior.
The sex dependence of Deaf1 function in mice is consistent with a greater role for 5-HT1A autoreceptors in sensitivity to depression in men.
we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Results suggest that 5HT acting at 5HT1aR in the Kolliker-Fuse nucleus may modulate both the intrinsic and extrinsic sources of respiratory rhythm variability.
a leading role of the postsynaptic 5-HT1AR in adult hippocampal neurogenesis and might open an important link to depression.
Among patients with major depressive disorder, it was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes.
Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A-receptors.
the activation of TLR3 promotes the loss of RGCs and their axons by elevating Rtca levels in the retina. Also, the results presented in this study show that Rtca regulates JNK3 expression in the retina.
Findings suggest an important role for 5-hydroxytryptamine 1A autoreceptors, and thus dorsal raphe nucleus, nucleus accumbens 5-hydroxytryptamine neuronal activity, in the etiology and vulnerability to cocaine reward and addiction.
Findings indicate that cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism.
The results of this study suggested that the hallucinogen action of 5-MeO-DMT is mediated by simultaneous alterations of the activity of cerebral cortex also supporting a role of 5-HT(1A)-R stimulation in V1 and PFC.
serotonin plays a fundamental role in arthritis through the regulation of the Th17/T-regulatory cell balance and osteoclastogenesis
Results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor-mediated dorsal raphe neuronal activity
Results indicate that postsynaptic 5-HT1A receptors exert a modulatory function in food intake in free-feeding and fasted mice, which for the first time shows an involvement of postsynaptic 5-HT1A receptors in feeding behavior
It plays a key role in the enhancement of prefrontal dopamine release.
the results of our systemic study increases our knowledge of the roles of NK1R and 5-HT1AR in melanogenesis and provides possible, novel therapeutic strategies for treatment of skin hypo/hyperpigmentation.
Study related 5-HT1A -cortical thickness correlation coefficients to the number of tracts connecting that region and the raphe, as measured by diffusion tensor imaging. The 5-HT1A -cortical thickness association correlated significantly with the number of tracts to each region. Defect in the raphe may affect the PCC within the default mode network in major depressive disorder through serotonergic fibers.
The results suggest that HTR1A/1B DNA hypomethylation and its interaction with recent life stress might drive impaired antidepressant treatment response. Meanwhile, DNA methylation, in turn, was modified by antidepressant treatment and environments.
Study found a significant interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Mean connectivity in the right inferior parietal lobule was positively correlated with working memory performance.
results provide further supportive evidence of the effect of HTR1A and HTR5A on the etiology of schizophrenia and suggest that the selected genetic variations in HTR5A may be involved in impaired executive function.
It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer.
Studied association of aggression and 5-HTTLPR, 5HTR1A, and 5HTR2A genetic polymorphisms in industrial Russian and traditional Tanzanian population groups.
Our results are in line with preclinical data, mouse model knockout studies as well as previous clinical analyses in major depressive disorder, demonstrating the two-pronged effect of the G allele on 5-HT1A receptor binding for, we believe, the first time.
In summary, our results suggest that, by genetic association, the mu-opioid receptor interacts with serotonin transporter and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.
Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different
Review/Meta-analysis: antipsychotic treatment may be more effective in improving negative symptoms in schizophrenic C allele than in G allele carriers of the HTR1A rs6295 polymorphism.
The rs6295 single nucleotide polymorphism (SNP) in the 5HTR1A promoter region was associated with suicide attempt, psychiatric hospitalizations, and substance use disorder
the rs6295 SNP, as a suspected variant that indicates susceptibility to schizophrenia, exhibited a higher transcriptional activity.
This study demonstrated that a significant decrease in the protein level of 5-HT1A in major depression disorder.
5-HT1A rs10042486 was significantly associated with schizophrenia
Results reveal the broad dependence that the 5-HT1A receptor has on plasma membrane properties, demonstrating that membrane lipid composition is a biochemical control parameter and highlighting the possibility that compositional changes related to aging, diet, or disease could impact cell signaling functions
Sphingosine modulates the function of human serotonin1A receptors.
The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain.
5-HT1A C-1019G (rs6295) can predict aripiprazole treatment response specifically for cognitive and depressive symptoms in schizophrenia.
results show that the oxidation of the hydroxyl group of cholesterol in live cells resulted in enhancement of agonist binding and G-protein coupling to the serotonin1A receptor with no appreciable change in overall membrane order; results extend our understanding of the structural requirements of cholesterol for receptor function
Polymorphism in the serotonin receptor 1A gene may affect tractability in horses, with the effect partially different depending on sex.
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
, serotonin receptor 1A
, serotonin receptor 2A
, 5-hydroxytryptamine receptor 1A
, 5-hydroxytryptamine (serotonin) receptor 1A
, 5-HT1A receptor
, G-protein coupled receptor 18
, 5-HT1a receptor
, guanine nucleotide-binding regulatory protein-coupled receptor
, Serotonin receptor 1A