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Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin (show INS Proteins) signaling
Decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss in temporal lobe epilepsy.
The Drosophila serotonin receptor 1A has a role in promoting baseline sleep.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(1A)-like receptors with 8-OH-DPAT increases overall aggression; 5-HT(1A)-like receptor manipulation primarily affects wing threats and fencing
5-HT(2) receptors are coupled to phospholipase C (show PLC Proteins) in bovine ciliary epithelium.
the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
role of cholesterol in solubilization of G-protein-coupled serotonin 1A receptors
ligand binding function of the 5-HT(1A) receptor is a cholesterol-dependent phenomenon that is not related to the ability of cholesterol to modulate membrane order
Increased levels of 5-HT1A receptor binding were seen in the raphe nuclei following chronic ethanol self-administration.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
Significantly lower 5-HT1A binding is found in s-carrier subjects (5-HTTLPR (show SLC6A4 Proteins) genotype) in both cortical brain regions and the raphe nuclei.
5-HT1A receptor levels increase during development in the female brain from pre-to peripuberty.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(1A), SST (show SST Proteins)(1), and SST (show SST Proteins)(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP (show Vip Proteins)) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Since the 5-HT(1A) and 5-HT(2) agonists decreased and increased, respectively, the duration of TI, different serotonin receptor (show HTR1B Proteins) subtypes may play distinct roles in the modulation of TI in the guinea pig.
activation of the 5-HT1A receptor (show CC2D1A Proteins) during the postnatal period may reduce anxiety levels, but increase depression levels during adulthood via different multiple molecules in the mPFC and ventral hippocampus.
5-HT1A autoreceptor expression in serotonin neurons requires Freud-1 (show CC2D1A Proteins) and is linked to anxiety/depression-like behavior.
The sex dependence of Deaf1 (show DEAF1 Proteins) function in mice is consistent with a greater role for 5-HT1A autoreceptors in sensitivity to depression in men.
we showed that gravity changes induced differential modulation of gene expression of BDNF (show BDNF Proteins) and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Results suggest that 5HT (show DDC Proteins) acting at 5HT1aR in the Kolliker-Fuse nucleus may modulate both the intrinsic and extrinsic sources of respiratory rhythm variability.
Among patients with major depressive disorder, it was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes.
Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 (show GSK3a Proteins) requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A-receptors.
the activation of TLR3 (show TLR3 Proteins) promotes the loss of RGCs and their axons by elevating Rtca (show RTCD1 Proteins) levels in the retina. Also, the results presented in this study show that Rtca (show RTCD1 Proteins) regulates JNK3 (show MAPK10 Proteins) expression in the retina.
Findings indicate that cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate (show GRIN1 Proteins) cortical signalling through a 5-HT1A receptor (show CC2D1A Proteins)-dependent mechanism.
The results of this study suggested that the hallucinogen action of 5-MeO-DMT is mediated by simultaneous alterations of the activity of cerebral cortex also supporting a role of 5-HT(1A)-R stimulation in V1 and PFC (show CFP Proteins).
Our results are in line with preclinical data, mouse model knockout studies as well as previous clinical analyses in major depressive disorder, demonstrating the two-pronged effect of the G allele on 5-HT1A receptor binding for, we believe, the first time.
In summary, our results suggest that, by genetic association, the mu-opioid receptor (show OPRM1 Proteins) interacts with serotonin transporter (show SLC6A4 Proteins) and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.
Both expressions of CC2D1A (show CC2D1A Proteins) and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different
Review/Meta-analysis: antipsychotic treatment may be more effective in improving negative symptoms in schizophrenic C allele than in G allele carriers of the HTR1A rs6295 polymorphism.
The rs6295 single nucleotide polymorphism (SNP) in the 5HTR1A promoter region was associated with suicide attempt, psychiatric hospitalizations, and substance use disorder
This study demonstrated that a significant decrease in the protein level of 5-HT1A in major depression disorder.
5-HT1A rs10042486 was significantly associated with schizophrenia
Results reveal the broad dependence that the 5-HT1A receptor has on plasma membrane properties, demonstrating that membrane lipid composition is a biochemical control parameter and highlighting the possibility that compositional changes related to aging, diet, or disease could impact cell signaling functions
The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain.
5-HT1A C-1019G (rs6295) can predict aripiprazole treatment response specifically for cognitive and depressive symptoms in schizophrenia.
Polymorphism in the serotonin receptor 1A gene may affect tractability in horses, with the effect partially different depending on sex.
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
, serotonin receptor 1A
, serotonin receptor 2A
, 5-hydroxytryptamine receptor 1A
, 5-hydroxytryptamine (serotonin) receptor 1A
, 5-HT1A receptor
, G-protein coupled receptor 18
, 5-HT1a receptor
, guanine nucleotide-binding regulatory protein-coupled receptor
, Serotonin receptor 1A