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Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin signaling
Decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss in temporal lobe epilepsy.
The Drosophila serotonin receptor 1A has a role in promoting baseline sleep.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(1A)-like receptors with 8-OH-DPAT increases overall aggression; 5-HT(1A)-like receptor manipulation primarily affects wing threats and fencing
5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
role of cholesterol in solubilization of G-protein-coupled serotonin 1A receptors
ligand binding function of the 5-HT(1A) receptor is a cholesterol-dependent phenomenon that is not related to the ability of cholesterol to modulate membrane order
Increased levels of 5-HT1A receptor binding were seen in the raphe nuclei following chronic ethanol self-administration.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
Significantly lower 5-HT1A binding is found in s-carrier subjects (5-HTTLPR genotype) in both cortical brain regions and the raphe nuclei.
5-HT1A receptor levels increase during development in the female brain from pre-to peripuberty.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(1A), SST(1), and SST(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Since the 5-HT(1A) and 5-HT(2) agonists decreased and increased, respectively, the duration of TI, different serotonin receptor subtypes may play distinct roles in the modulation of TI in the guinea pig.
We found that age-dependent 5-HT1A receptor upregulation in the hippocampus, amygdala, and dorsal raphe nucleus is accompanied by the expression of the LRRK2 mutant phenotype
Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its small es, Cyrillicontent in the mouse brain
interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
Results indicate that 5-HT may facilitate nociception and intensify fear-induced antinociception, respectively, at 5-HT1A and 5-HT2C receptors located in the amygdala of mice. The impairment produced by systemic fluoxetine on fear-induced antinociception provoked by intra-amygdala MK-212 suggests that this type of fear-induced antinociception may be modulated by serotonin reuptake inhibitors.
findings demonstrate that RGS protein control of hippocampal 5-HT1AR signaling is necessary and sufficient to account for the antidepressant-like phenotype in the RGSi Galphai2 knock-in mice.
Down-regulation of Htr1a in the hippocampus after maternal separation - early life stress event is associated with vulnerability to excessive voluntary ethanol consumption later in life.
5-HT1AR KO affected anxiety in male mice, and fear memory and prepulse inhibition in female mice. 5-HT1AR genotype moderated the effects of maternal prenatal stress exposure on social behavior of male offspring and on activity levels of female offspring. Findings indicate that 5-HT1A receptor availability affect outcomes of the offspring resulting from maternal prenatal stress exposure sex-specifically.
Under basal conditions, 5-HT1AR overexpressing animals presented high corticosterone levels and a lower mineralocorticoid/glucocorticoid receptor ratio. After pre-exposure to a single stressor, they showed a high anxiety-like response, a blunted increase in corticosterone levels, higher prefrontal c-Fos activation, and lack of downregulation of hippocampal long-term potentiation.
Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor in modulating anxiety-related behaviors.
activation of the 5-HT1A receptor during the postnatal period may reduce anxiety levels, but increase depression levels during adulthood via different multiple molecules in the mPFC and ventral hippocampus.
Zn can modulate both presynaptic and postsynaptic 5-HT1ARs.
5-HT1A autoreceptor expression in serotonin neurons requires Freud-1 and is linked to anxiety/depression-like behavior.
The sex dependence of Deaf1 function in mice is consistent with a greater role for 5-HT1A autoreceptors in sensitivity to depression in men.
we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Results suggest that 5HT acting at 5HT1aR in the Kolliker-Fuse nucleus may modulate both the intrinsic and extrinsic sources of respiratory rhythm variability.
a leading role of the postsynaptic 5-HT1AR in adult hippocampal neurogenesis and might open an important link to depression.
Among patients with major depressive disorder, it was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes.
Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A-receptors.
the activation of TLR3 promotes the loss of RGCs and their axons by elevating Rtca levels in the retina. Also, the results presented in this study show that Rtca regulates JNK3 expression in the retina.
Findings suggest an important role for 5-hydroxytryptamine 1A autoreceptors, and thus dorsal raphe nucleus, nucleus accumbens 5-hydroxytryptamine neuronal activity, in the etiology and vulnerability to cocaine reward and addiction.
HTR1A -1019C/G polymorphism influences anxiety levels by modulating parasympathetic tone.
Our results indicate that 5-HT1A receptor genetic polymorphism modulates the activity of resting-state functional connectivity(FC) within brain networks including the default mode network and salience network. These genotype-related alterations in brain networks and FC may provide novel insights into the neural mechanism underlying the predisposition for affective disorders in G allele carriers
Association of rs10042486 CT genotype and OCD is statistically significant among Iranian patients.
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT1A receptor profile comparable to affective disorders as increased 5-HT1A receptor binding is a well published phenotype of depression. Thus, epistasis between BDNF and HTR1A may contribute to the multifactorial risk for affective disorders.
Study found that 5-HT1A binding in the brain was greater in suicides, independent of major depression, while alcohol use disorder was associated with higher 5-HT1A binding but only in suicides
Our work suggests that the studied polymorphisms, 5HT1A (rs6295), 5HT1B (rs6296), and 5HT2C (rs6318), were not related to the presence of temporal lobe epilepsy (TLE), psychiatric comorbidities in TLE, and epilepsy-related factors.
the results of our systemic study increases our knowledge of the roles of NK1R and 5-HT1AR in melanogenesis and provides possible, novel therapeutic strategies for treatment of skin hypo/hyperpigmentation.
Study related 5-HT1A -cortical thickness correlation coefficients to the number of tracts connecting that region and the raphe, as measured by diffusion tensor imaging. The 5-HT1A -cortical thickness association correlated significantly with the number of tracts to each region. Defect in the raphe may affect the PCC within the default mode network in major depressive disorder through serotonergic fibers.
The results suggest that HTR1A/1B DNA hypomethylation and its interaction with recent life stress might drive impaired antidepressant treatment response. Meanwhile, DNA methylation, in turn, was modified by antidepressant treatment and environments.
Study found a significant interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Mean connectivity in the right inferior parietal lobule was positively correlated with working memory performance.
results provide further supportive evidence of the effect of HTR1A and HTR5A on the etiology of schizophrenia and suggest that the selected genetic variations in HTR5A may be involved in impaired executive function.
It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer.
Studied association of aggression and 5-HTTLPR, 5HTR1A, and 5HTR2A genetic polymorphisms in industrial Russian and traditional Tanzanian population groups.
Our results are in line with preclinical data, mouse model knockout studies as well as previous clinical analyses in major depressive disorder, demonstrating the two-pronged effect of the G allele on 5-HT1A receptor binding for, we believe, the first time.
In summary, our results suggest that, by genetic association, the mu-opioid receptor interacts with serotonin transporter and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.
Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different
Review/Meta-analysis: antipsychotic treatment may be more effective in improving negative symptoms in schizophrenic C allele than in G allele carriers of the HTR1A rs6295 polymorphism.
The rs6295 single nucleotide polymorphism (SNP) in the 5HTR1A promoter region was associated with suicide attempt, psychiatric hospitalizations, and substance use disorder
the rs6295 SNP, as a suspected variant that indicates susceptibility to schizophrenia, exhibited a higher transcriptional activity.
This study demonstrated that a significant decrease in the protein level of 5-HT1A in major depression disorder.
Polymorphism in the serotonin receptor 1A gene may affect tractability in horses, with the effect partially different depending on sex.
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
, serotonin receptor 1A
, serotonin receptor 2A
, 5-hydroxytryptamine receptor 1A
, 5-hydroxytryptamine (serotonin) receptor 1A
, 5-HT1A receptor
, G-protein coupled receptor 18
, 5-HT1a receptor
, guanine nucleotide-binding regulatory protein-coupled receptor
, Serotonin receptor 1A