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5-HT(2) receptors are coupled to phospholipase C (show PLC Proteins) in bovine ciliary epithelium.
Our results indicate that prolonged Htr2b activation in murine beta-cells decreases glucose-stimulated insulin secretion and mitochondrial activity by mechanisms likely dependent on enhanced PGC1a/PPARygexpression.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2 (show CA2 Proteins)+) flux that enhance mitochondrial metabolism.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT (show DDC Proteins) activation of 5-HT2B receptors in postnatal microglial cells
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter (show SLC6A4 Proteins) has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR (show PPARA Proteins)-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT (show DDC Proteins)(2A)/5HT (show DDC Proteins)(2B) receptors.
These findings suggest that 5-HT (show DDC Proteins) promotes CCN2 (show CTGF Proteins) production through the 5-HT2AR in growth plates, and that it represses CCN2 (show CTGF Proteins) production through the 5-HT2BR in articular cartilage for harmonized development of long bones
MFSD2B, CCL20 (show CCL20 Proteins) and STAT1 (show STAT1 Proteins), or STARD7 (show STARD7 Proteins) and ZNF512 genes may be risk or protect factors in prognosis of ADC (show ADC Proteins); HTR2B, DPP4 (show DPP4 Proteins), and TGFBRAP1 (show TGFBRAP1 Proteins) genes may be risk factors in prognosis of SQC (show QPCT Proteins).
The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin (show INS Proteins) sensitivity among HTR2B Q20* carriers with low testosterone levels.
Study describes the crystal structure of Lysergic acid diethylamide (LSD (show DNASE1L3 Proteins)) in complex with the human serotonin receptor (show HTR1B Proteins) 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD (show DNASE1L3 Proteins), providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety.
The 5-HT2B receptor may contribute to the regulation of human glucagon (show GCG Proteins) and glucose homeostasis and the interplay between glucagon (show GCG Proteins) and insulin (show INS Proteins) secretion.
Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke.
the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis
Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity.
distribution of serotonin 2B receptor is species different in the pig small intestine and the intensity of serotonin 2B receptor becomes stronger as the small intestine matures
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
5-hydroxytryptamine (serotonin) receptor 2B
, 5-hydroxytryptamin receptor
, 5-hydroxytryptamine receptor 2B
, 5HT2B receptor
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 2B-like
, NP75 protein
, 5-HT2B serotonin receptor
, 5-HT 2B receptor
, 5-hydroxytryptamine 2B receptor
, 5-hydroxytryptamine receptor 2B variant b
, stomach fundus serotonin receptor
, serotonin 2B receptor