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cortisol up-regulated the expression and function of two serotonin (S) receptors, HTR2c and HTR5a.
This study demonistrated that loss of htr5A gene strongly upregulates 5-HT1A receptor-mediated currents in the prefrontal cortex.
results provide further supportive evidence of the effect of HTR1A and HTR5A on the etiology of schizophrenia and suggest that the selected genetic variations in HTR5A may be involved in impaired executive function.
Results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression
Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders.
Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels
Association of a SNP of HTR5A gene is a susceptibility factor to bipolar disease in Bulgarian population.
N-glycosylation of the N6 residue is important for the membrane expression of this 5-HT5A neurotransmitter receptor; a requirement for receptor function.
In individuals in Brazil with the A/A variant of the -1438G/A polymorphism of the 2A receptor gene, the effect of cultural consonance in family life on depressive symptoms over a 2 year period was larger than those with the G/A or G/G variants.
The receptor has been transiently expressed in Cos M6 cells and exhibits a pharmacological profile closely resembling the mouse and rat 5-HT5A receptors with high, specific binding for ergotamine and methiothepin.
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.
5-hydroxytryptamine (serotonin) receptor 5A
, 5-hydroxytryptamine receptor 5A
, 5-hydroxytryptamine receptor 5A-like
, serotonin receptor 5A