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These data indicate that PR, both in the presence and absence of ligand, attenuates IFN-induced STAT1 signaling, culminating in significantly abrogated activation of genes transcribed in response to IFNs.
HBV contributes to the monocyte inflammatory response but inhibits their IFN-alpha/beta responsiveness to impair antiviral innate immunity. These effects are mediated via differential phosphorylation of Tyr701 and Ser727 of STAT1.
Our findings suggest that MTMR2 is an important promoter in gastric cancer (GC) invasion and metastasis by inactivating IFNgamma/STAT1 signaling and may act as a new prognostic indicator and a potential therapeutic target for GC.
Levels of IFNL are increased in serum and inflamed ileal tissues from patients with Crohn's disease and associated with a loss of Paneth cells via STAT1 signaling.
annexin A2 (ANXA2), N-myc downstream regulated gene 1 (NDRG1) and signal transducer and activator of transcription 1 (STAT1) as biomarkers of LACC patients' responsiveness to CRT.
With Heterozygous STAT1 Gain-of-Function Mutation.
Inhibiting the responsible O-acetylglucosamine (O-GlcNAc) transferase abolishes STAT1 activity together with indoleamine 2,3-dioxygenase upregulation
The present study reveals a possible endocrine-resistant mechanism by which STAT1 modulates ERa signalling and confers tamoxifen resistance. Targeting of STAT1 is a potential treatment strategy for endocrine-resistant breast cancers
we have shown an association between heterozygous STAT1 mutations and a worsening progressive, combined immunodeficiency with decline over time in T, B, and NK cells. This novel mutation expands the known phenotype of STAT1 GOF disease, presenting with cavitating PJP, without classic CMC or autoimmune features.
Signal transducer and activator of transcription-1 protein expression showed no significant difference
Results suggest that the expression and activity of peroxisome proliferator-activated receptors (PPARs) in peripheral blood mononuclear cells (PBMCs) varies with respect to signal transducer and activator of transcription STAT1 and STAT6 trafficking in diabetic patients with and without cardiovascular diseases.
Multi-OMICS analyses unveil STAT1 as a potential modifier gene in mevalonate kinase deficiency.
Results indicate that pSTAT1 positivity is a potential biomarker for patient with breast cancer, since pSTAT1 positivity significantly reflects PDL1 and HLA class I expressions on tumor cells as well as PDL1 expression on tumorinfiltrating CD8positive T cells.
The level of p-JAK2 and p-STAT1 increased after FRK overexpression, while they decreased after FRK downregulation both in U251 and U87 cells. However, FRK had no effect on STAT3 phosphorylation. FRK-induced STAT1 activation was not dependent on JAK2. FRK associated with STAT1, induced STAT1 nuclear translocation and regulated the expressions of STAT1-related target genes.
A significant positive correlation was demonstrated between STAT1 and STAT2 and also between STAT1 and STAT3.
Together these results indicate that IRF1 promotes DNA binding of STAT1, which can in turn participate in a positive feedback loop of JAK-STAT signaling.
These data suggest that the JAK2/STAT1 pathway in TNBC might regulate the dynamic expression of PD-L1 that is induced in the setting of an inflammatory response
data indicate that Hematopoietic stem cell transplantation for patients with GOF-STAT1 mutations is curative but has significant risk of secondary graft failure and death.
Description of the role of inherited STAT1 and STAT3 mutations in the setting of human disease with highly variable phenotypes that include immunodeficiency, malignancy, and autoimmunity (review).
Study discovered that HCMV-induced STAT1 helps direct motility, differentiation, and polarization of infected monocytes. These results suggest the identification of a proviral outcome for the activation of the traditionally antiviral player, STAT1, during HCMV infection of monocytes.
Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost.
of a secreted form of IFNL in mice results in loss of Paneth cells from intestinal tissues, via STAT1 and MLKL, controlled by caspase 8.
STAT1 activation drives macrophages toward an alternatively activated phenotype and enhances fibrogenesis indicating a potential STAT1-driven protective mechanism in tissue repair after ischemic injury.
Exposure to SUV leads to upregulation of IFNgamma and downstream pSTAT1/IRF-1/uSTAT1 signaling in the epidermis.
Study shows that the Stat1 C-terminal transactivation domain (TAD) is absolutely required for the recruitment of RNA polymerase II (Pol II) and for the establishment of active histone marks at the class II major histocompatibility complex transactivator promoter IV, whereas it is dispensable for histone acetylation at the guanylate binding protein 2 promoter but required for an efficient recruitment of Pol II.
this study emphasizes the pivotal role of the SOCS1/STAT1 axis in the regulation of inflammation in mesangial proliferative glomerulonephritis
Toxoplasma gondii infection increases phosphorylated Tyr701- and phosphorylated Ser727-STAT1 in the host cell nucleus.
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.
Canonical Ifn-gamma signaling via Ifngr1 and Stat1 is required for Parkinsonian neurodegenerative pathology
These results indicated that TLR4-dependent autophagy regulates microglial polarization and induces ischemic white matter damage via STAT1/6 pathway.
These data demonstrate that epithelial STAT1 is a male-specific tumor suppressor in colorectal cancer of mice and humans.
The proatherosclerotic effects of tumor necrosis factor (ligand) superfamily member 12 (TWEAK) were mediated, at least in part, by signal transducer and activator of transcription 1 (STAT1) activation and expression of proinflammatory target genes.
Defective STAT1 activation in Casp11(-/-) colons during disease progression.
SIRT2 deacetylates cyclin-dependent kinase 9 (CDK9) in a type I IFN-dependent manner and that the CDK9 deacetylation is essential for STAT1 phosphorylation at Ser-727.
Suppression of STAT1 activation shaped the functional identity and effector characteristics of memory CD4+ T cells.
The authors describe a critical role for STAT1 in promoting T-cell survival by maintaining sufficient MHC class I expression to evade NK cell-mediated killing.
High STAT1 expression is associated with resistance to Oncolytic Virotherapy in gliobalstoma.
propose a role for Intu in protecting cells and tissues after injury by targeting STAT1 for degradation and maintaining primary cilia
interferon-gamma-signal transducer and activator of transcription 1 (IFN-gamma-Stat1) pathway was required for generating colitogenic macrophages, given that Stat1-/- mice had less severe colitis and fewer colitogenic macrophages
Study in MMTV/MT6 and MMTV/NIC breast cancer mouse models show that ShcA phosphotyrosine motifs potentiate immune suppression by limiting signal transducer and activator of transcription (STAT)-1-driven anti-tumour immunity, while simultaneously increasing STAT3 immunosuppressive signals.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 nuclear translocation.
Nsp1beta inhibits interferon-activated STAT1/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin on ovarian cell functions.
the majority of the STAT1/STAT2/IRF9 (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 at Ser-727 and STAT1 binding to the caspase-8 promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
The tight junction protein ZO-2 is involved in regulation of vascular smooth muscle cells growth control upon vascular injury that is mediated by the transcription factor Stat1.
Report interferon-tau dependent STAT1 regulation of SOCS genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2.
Study establishes a role for Stat4 in zebrafish great vessel development, and suggests that Stat4 may serve as a therapeutic target for great vessels defects.
The role of stat1b in zebrafish hematopoiesis.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa
, signal transduction and activation of transcription 1
, signal transduction and activation of transcription 1a