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High STAT1 expression is associated with Melanoma.
These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 (show CD274 Proteins) in human BM and WJMSCs were mediated by STAT1 signaling, and not by PI3K (show PIK3CA Proteins)/RACalpha (show AKT1 Proteins) serine/threonineprotein kinase signaling
STAT1 plays a pivotal role as a tumor suppressor in glioma.
the present study revealed a negative correlation between the expression of the STAT-1 gene and the glioma grade, as well as between STAT-1 and mutant p53 (show TP53 Proteins) expression. The negative correlation between STAT-1 and the pathological level of glioma suggested that STAT-1 may be associated with the occurrence and development of glioma, and may be a diagnostic biomarker and therapeutic target for the malignancy of glioma.
PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4 (show IL4 Proteins); PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 (show STAT6 Proteins) phosphorylation in M(IL-4 (show IL4 Proteins)) cells
PVT1 interacts with STAT1 to inhibit IFN-alpha (show IFNA Proteins) signaling and tumor cells proliferation.
STAT1 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence
High STAT1 expression is associated with head and neck squamous cell carcinoma.
The research described here specifies where in the JAK (show JAK3 Proteins)/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 (show RTN2 Proteins) is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds.
These results reveal that STAT1 pS727 regulates growth and differentiation in JAK (show JAK3 Proteins)-STAT activated neoplasms and suggest that Mediator kinase inhibition represents a therapeutic strategy to regulate JAK (show JAK3 Proteins)-STAT signaling
these data suggest that aloin attenuated LPSinduced inflammation by inhibiting ROSmediated activation of the JAK1STAT1/3 signalling pathway, thereby inhibiting the nuclear translocation of STAT1/3 in RAW264.7 cells.
STAT1 binds to the IL-22 (show IL22 Proteins) promoter and directly antagonizes STAT3 (show STAT3 Proteins)-mediated IL-22 (show IL22 Proteins) induction.
Downregulated SOCS1 (show SOCS1 Proteins) expression activates the JAK1 (show JAK1 Proteins)/STAT1 pathway and promotes polarization of macrophages into M1 type.
The Lipopolysaccharide and IFN-beta (show IFNB1 Proteins)-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn(2+) with the membrane permeable chelator N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.
The possibility that the Gas6 (show GAS6 Proteins)-Mer (show ERH Proteins)-PI3K/Akt (show AKT1 Proteins)-STAT1-LXR (show NR1H3 Proteins)-Arg2 (show ARG2 Proteins) pathway plays an essential role for resolving inflammatory response in acute lung injury.
The results of this study strongly indicated that release of interferons by neuronal cells expressing polyglutamine-TBP (show TBP Proteins) leads to induction of STAT1 and consequent downregulation of miR (show MLXIP Proteins)-29a/b by a series of cell signaling events.
STAT1 is required to protect B cell development during murine norovirus infection.
Rigidity plays a key role in the toxicity of multi-walled carbon nanotubes and results in increased inflammatory, immunologic, and fibrogenic effects in the lung. STAT1 is an important protective factor in the fibroproliferative response to rMWCNTs, regulating both induced TGF-beta1 (show TGFB1 Proteins) production and Smad2 (show SMAD2 Proteins)/3 phosphorylation status.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Proteins) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa
, signal transduction and activation of transcription 1
, signal transduction and activation of transcription 1a