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Data show that RNF2 (show RNF2 Proteins) promotes STAT1/STAT2 (show STAT2 Proteins) disassociation from DNA.
In lipotoxic hepatocytes, MLK3 activates a MAPK (show MAPK1 Proteins) signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 (show CXCL10 Proteins) transcriptional upregulation.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (show NOS2 Proteins) and COX-2, in PRV-infected RAW264.7 cells by inhibiting STAT1/3 dependent NF-kappaB (show NFKB1 Proteins) activation and inducing Nrf2mediated HO-1 (show HMOX1 Proteins) expression.
Results showed that the mRNA expression of STAT1 increased during the early stage of adipogenesis under the regulation of Bcl6 (show BCL6 Proteins).
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 Proteins), ERK1 (show MAPK3 Proteins), ERK2 (show MAPK1 Proteins) and STAT1 pathways.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 expression and NF-kappaB (show NFKB1 Proteins) activity.
Treatment of the haplotype Npr1 (show NPR1 Proteins)(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65 (show NFkBP65 Proteins)), and STAT1.
PHLPP1 reduced IFN-gamma (show IFNG Proteins)-stimulated but not LPS (show TLR4 Proteins)-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-gamma-induced (show SAMHD1 Proteins) ser (show SIGLEC1 Proteins)(727) STAT1 phosphorylation and iNOS (show NOS2 Proteins) expression.
Data demonstrate that STAT1 is a key orchestrator of cytokine-producing innate lymphoid cells responses during viral infection via ILC (show CCL27 Proteins)-extrinsic regulation of IL-33 (show IL33 Proteins) and IL-23 (show IL23A Proteins).
The results of the present study indicate that ISTP may inhibit TARC/CCL17 (show CCL17 Proteins) production in human epidermal keratinocytes via the STAT1 signaling pathway and may be associated with the inhibition of IL33 (show IL33 Proteins) production.
In human gastrointestinal stromal tumors (GIST) cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 (show CD274 Proteins) via STAT1 inhibition. PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) blockade is a promising strategy to improve the effects of targeted therapy in GISTs
STAT3 (show STAT3 Proteins)/STAT1 ratios are better clinical predictors in colorectal carcinoma as compared to STAT3 (show STAT3 Proteins) or STAT1 levels alone.
In a subgroup of Schizophrenic patients, blood levels of STAT1 were significantly higher compared to the control group.
Suggest a positive feedback mechanism via the STAT1/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK (show JAK3 Proteins)/STAT in TNFalpha (show TNF Proteins)-mediated senescence.
our findings suggested that OSM (show OSM Proteins) suppresses SLUG expression and tumor metastasis of lung adenocarcinoma cells through inducing the inhibitory effect of the STAT1-dependent pathway and suppressing the activating effect of STAT3 (show STAT3 Proteins)-dependent signaling
miR (show MLXIP Proteins)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (show TGFB1 Proteins) signalling via STAT1/SOCS3 (show SOCS3 Proteins).
The phosphorylation of STAT1 promotes its binding to TRADD (show TRADD Proteins), and thus recruits Fas (show FAS Proteins)-associated protein with DD (FADD (show FADD Proteins)) and caspase 8 (show CASP8 Proteins) to form DISC complexes.
The results demonstrate that cystatin B (show CSTB Proteins) interferes with the STAT-1 signaling and IFN-beta (show IFNB1 Proteins)-antiviral responses perpetuating HIV in macrophage reservoirs.
propose that one molecule of C protein associates with the STAT1:STAT2 (show STAT2 Proteins) heterodimer, inducing a conformational change to an antiparallel form, which is easily dephosphorylated
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Proteins) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Proteins) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1/STAT2 (show STAT2 Proteins) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Proteins) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Proteins)/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Proteins) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Proteins)-727 and STAT1 binding to the caspase-8 (show CASP8 Proteins) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Proteins) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Proteins) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Proteins).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, HAI-2 related small protein
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 4
, signal transducer and activator of transcription 1
, transcription factor ISGF-3
, activator of transcription
, signal transduction