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Lysine (K)-Specific Methyltransferase 2B Products

(Lysine (K)-Specific Methyltransferase 2B (KMT2B))
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]. stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured Lysine (K)-Specific Methyltransferase 2B Categories

Lysine (K)-Specific Methyltransferase 2B Antibodies

High quality antibodies with extensive validation data.

Recommended Lysine (K)-Specific Methyltransferase 2B Antibodies

Cat. No.
Reactivity Human
Application ELISA, FACS, IHC, WB
  • (6)
Cat. No. ABIN7193438
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application ELISA, ICC, IF, IHC, WB
  • (2)
Cat. No. ABIN6263280
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
  • (2)
Cat. No. ABIN184881
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Lysine (K)-Specific Methyltransferase 2B products

Zhang, Dominguez-Sola, Hussein, Lee, Holmes, Bansal, Vlasevska, Mo, Tang, Basso, Ge, Dalla-Favera, Pasqualucci: "Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis." in: Nature medicine, Vol. 21, Issue 10, pp. 1190-8, (2015) (PubMed).

Dubuc, Remke, Korshunov, Northcott, Zhan, Mendez-Lago, Kool, Jones, Unterberger, Morrissy, Shih, Peacock, Ramaswamy, Rolider, Wang, Witt, Hielscher, Hawkins, Vibhakar, Croul, Rutka, Weiss, Jones et al.: "Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. ..." in: Acta neuropathologica, Vol. 125, Issue 3, pp. 373-84, (2013) (PubMed).

Chikanishi, Fujiki, Hashiba, Sekine, Yokoyama, Kato: "Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 865-70, (2010) (PubMed).

Chaturvedi, Hosey, Palii, Perez-Iratxeta, Nakatani, Ranish, Dilworth, Brand: "Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 43, pp. 18303-8, (2009) (PubMed).

Huntsman, Chin, Muleris, Batley, Collins, Wiedemann, Aparicio, Caldas: "MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines." in: Oncogene, Vol. 18, Issue 56, pp. 7975-84, (2000) (PubMed).

Synonyms and alternative names related to Lysine (K)-Specific Methyltransferase 2B

lysine methyltransferase 2B (KMT2B), HRX2, MLL1B, MLL2, MLL4, TRX2, WBP7

Protein level used designations for Lysine (K)-Specific Methyltransferase 2B

  • KMT2D
  • WBP-7
  • WW domain binding protein 7
  • WW domain-binding protein 7
  • histone-lysine N-methyltransferase 2B
  • histone-lysine N-methyltransferase MLL4
  • lysine N-methyltransferase 2B
  • lysine N-methyltransferase 2D
  • mixed lineage leukemia gene homolog 2
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4
  • myeloid/lymphoid or mixed-lineage leukemia 4
  • myeloid/lymphoid or mixed-lineage leukemia protein 4
  • trithorax homolog 2
  • trithorax homologue 2
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