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Cep70 is important for Cdc42 and Rac1 activation to promote angiogenesis.
Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer.
these results demonstrate a critical role for Cep70 in the development and progression of breast cancer.
Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization
findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation
data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation
These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly.
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity).
centrosomal protein 70kDa
, centrosomal protein 70 kDa
, centrosomal protein of 70 kDa
, centrosomal protein of 70 kDa-like
, p10-binding protein