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Browse our SGCD Proteins (SGCD)

Full name:: Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) Proteins (SGCD)

On www.antibodies-online.com are 11 Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) Proteins from 6 different suppliers available. Additionally we are shipping SGCD Antibodies (100) and SGCD Kits (6) and many more products for this protein. A total of 125 SGCD products are currently listed.

Synonyms:: 35DAG, 35kDa, BEST:GH21860, CG14808, CMD1L, CT34621, DAGD, delta-SG, Dmel\\CG14808, DmSCG-gammadelta, EG:4F1.1, GH21860, SG-delta, Sgcd, SGCDP, SGD, wu:fc49e11, zgc:110649

list all proteins	Gene Name	GeneID	UniProt
	SGCD	6444	Q92629
	SGCD	24052	P82347
Rat SGCD	SGCD	497892
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Fruit Fly (Drosophila melanogaster) Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

deletion of the delta-sarcoglycan gene produced disrupted flight muscles with shortened sarcomeres and disorganized M lines

Zebrafish Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

Protein required for muscle organization.
delta-sarcoglycan plays an important role in early heart and muscle development.

Human Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

Study identified 2 non-synonymous missense mutations: c.C652T, p.R218W in ACVRL1, c.C717G, p.D239E in SGCD in Chinese population with total anomalous pulmonary venous return.
Dilated cardiomyopathy mutations in delta-sarcoglycan can exert a dominant negative effect on dystrophin-glycoprotein complex function leading to myocardial mechanical instability that may underlie the pathogenesis of delta-sarcoglycan-associated DCM.
haplotype -_G composed of c.-100~-110 and A848G confers higher susceptibility to dilated cardiomyopathy in the Mongoloid population.
CC genotype of the delta-sarcoglycan gene polymorphism rs13170573 is associated with obstructive sleep apnea in the Chinese population
Genetic variation at the delta-sarcoglycan locus elevates heritable sympathetic nerve activity in human twin pairs
Finding questions the pathological relevance of sequence variant of the delta-sarcoglycan gene for causing familial autosomal-dominant dilated cardiomyopathy.
These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport.
The 5'-UTR G to C polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with hypertrophic cardiomyopathy.
The limb-girdle muscular dystrophy patients with delta-sarcoglycan deficient LGMD2F do not enable an accurate prediction of the genotype.

Mouse (Murine) Sarcoglycan, delta (35kDa Dystrophin-Associated Glycoprotein) (SGCD) interaction partners

Collectively, these results confirm and extend understanding of a functional role for the dystrophin-glycoprotein complex in the contractile properties of airway smooth muscle and demonstrate that this results in altered lung function in vivo.
Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely.
Despite SGC rescue, and contrary to previous observations obtained with WT/mdx chimeras low levels of ESC incorporation were insufficient to produce histological corrections in SGdelta-KO skeletal muscle or heart.
This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage.
dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1)
This study demonstrated that the severe cardiac dysfunction in Scgd(-/-) mice at 8 months.
delta-SG isoforms may stabilize gamma-SG and microSPN in transverse tubules and sarcoplasmic reticulum membranes and this possible complex may play a role in maintenance of stable level of resting cytosolic calcium concentration in skeletal muscle.
Abscence of sarcoglycan delta may be related to pathogenesis of muscular dystrophy.
delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle
a delta-sarcoglycan isoform is localized at the sarcoplasmic reticulum of mouse skeletal muscle
We propose that MDPCs may be the promising progenitor cells in skeletal muscle to treat delta-sarcoglycan complex mutant cardiomyopathy.
The S151A delta-sarcoglycan gene mutation acts in a dominant negative manner to produce trafficking defects that disrupt nuclear localization of lamin A/C and emerin, thus linking together two common mechanisms of inherited cardiomyopathy.
mdx and sgcd-/- arteries had decreased distensibilities in pressure-diameter tests, mdx arteries exhibiting elevated circumferential stresses, and mdx and sgcd-/- arteries generated elevated axial loads and stresses in axial force-length tests.
Steroid treatment causes deterioration of myocardial function in the delta-sarcoglycan-deficient mouse model for dilated cardiomyopathy.
These results indicate that mechanical stress is not a primary cause for the loss of other sarcoglycans (SG) when the delta-SG gene is deficient.
Sub-physiological sarcoglycan expression plays a critical role in ameliorating muscle disease in mdx mice.
Data demonstrate a novel function of the sarcoglycan complex in whole body glucose homeostasis and skeletal muscle metabolism, suggesting that the impairment of the skeletal muscle metabolism influences the pathogenesis of muscular dystrophy.

SGCD Protein Profile

Protein Summary

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Alternative names and synonyms associated with SGCD

sarcoglycan delta (SGCD)
Sarcoglycan delta (Scgdelta)
sarcoglycan, delta (dystrophin-associated glycoprotein) (sgcd)
sarcoglycan delta (sgcd)
sarcoglycan delta (Sgcd)
sarcoglycan, delta (dystrophin-associated glycoprotein) (Sgcd)
sarcoglycan, delta (Sgcd)

35DAG protein
35kDa protein
BEST:GH21860 protein
CG14808 protein
CMD1L protein
CT34621 protein
DAGD protein
delta-SG protein
Dmel\\CG14808 protein
DmSCG-gammadelta protein
EG:4F1.1 protein
GH21860 protein
SG-delta protein
Sgcd protein
SGCDP protein
SGD protein
wu:fc49e11 protein
zgc:110649 protein

Protein level used designations for SGCD

, , , , , , , , , , , , , , , , , , , , sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) CG14808-PA CG14808-PB CG14808-PC CG14808-PD Scgdelta-PA Scgdelta-PB Scgdelta-PC Scgdelta-PD delta-sarcoglycan sarcoglycan sarcoglycan delta sarcoglycan, delta (dystrophin-associated glycoprotein) 35 kDa dystrophin-associated glycoprotein delta-SG dystrophin associated glycoprotein, delta sarcoglycan placental delta sarcoglycan delta sarcoglycan 35DAG SG-delta sarcoglycan, delta (35kD dystrophin-associated glycoprotein)

GENE ID	SPECIES
462216	Pan troglodytes
31129	Drosophila melanogaster
324961	Danio rerio
416251	Gallus gallus
100528224	Ictalurus punctatus
6444	Homo sapiens
612079	Canis lupus familiaris
100240724	Sus scrofa
517059	Bos taurus
101837953	Mesocricetus auratus
24052	Mus musculus
497892	Rattus norvegicus

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