-
The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...
-
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
-
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK/PPARalpha/ATF2 pathway.
-
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK, AAT, signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2)
-
increased expression of the gene encoding PKCepsilon and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK expression
-
These data identified a role for ATF2 in regulating melanocyte responses.
-
suppression of tumorigenesis by JNK requires ATF2.
-
Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK signal pathway.
-
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 in M1 macrophages of White adipose tissue.
-
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
-
these studies show that the IL-1beta-induced increase in intestinal tight junction permeability was regulated by p38 kinase activation of ATF-2 and by ATF-2 regulation of MLCK gene activity
-
The ATF2 represses renin expression by drifting the transcriptional control of renin gene away from CRE-binding protein (CREB).
-
ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS
-
ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription.
-
MITF is downregulated by ATF2 in the skin of Atf2-/- mice, in primary human melanocytes, and in melanoma cell lines.
-
Growth factor-independent signaling pathways converge in the formation of an active c-Jun.AFT2 dimer, which induces the expression of the anti-apoptotic factor Bcl-X(L) that mediates a pro-survival response.
-
Data show that ATF-2 was rapidly phosphorylated and recruited to the Tnfa promoter following ligation of TLR2.
-
ATF-2 plays an important regulatory role in MAG expression at a specific stage of shi/shi oligodendrocyte differentiation.
-
P38 and this protein are involved in osteoblast osmotic response to elevated extracellular glucose
-
Role of ATF2 peptide in apoptosis of melanoma cells
