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Aberrant ERRgamma expression may contribute to the pathogenesis of FGR by regulating the transcriptional activity of HSD17B1.
Our genetic study demonstrated HSD17B1 937 G variant as a risk factor for infertility in women with stage I and II endometriosis in Polish Caucasian patients.
HSD17B1 is a promising marker to predict EC prognosis.
Macronutrient intakes were associated with serum estradiol level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal Japanese women.
the effect of 17beta-HSD1 expression on breast cancer cell transcript profile in steroid-deprived condition, was investigated.
Mutation in the 17-beta-hydroxysteroid dehydrogenase gene is associated with congenital adrenal hyperplasia.
Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated.
10 natural products were evaluated leading to inhibition of the activity of 17beta-HSD1 at the concentration of 25 muM, and six of them inhibit the activity over 50%.
The structure of human 17beta-HSD1 and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1's implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review]
These findings suggested that the HSD17B1 Ser312Gly polymorphism might confer genetic cancer susceptibility in an ethnic-dependent manner, especially among Caucasians.
The rs605059 polymorphism of the HSD17B1 gene is associated with increased risk of recurrent spontaneous abortion.
Review/Meta-analysis: HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer or endometriosis.
the HSD17B1 transcript and protein were identified in HeLa, SiHa, Ca Ski and C-33A cervical cancer cells.
Increased expression of HSD17B1 in NSCLC may contribute to an elevated intratissue level of E2 and consequently may support the development and spread of cancer.
The key enzymes of ovarian steroidogenesis, CYP 19 and 17beta-HSD, are active in the ovaries of postmenopausal women.
17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells.
E1-induced ERELuc activity in the inhibitor-treated uterus was reduced by the HSD17B1 inhibitor.
Single nucleotide polymorphism in HSD17B1 gene is associated with hepatocellular carcinoma.
Onset of epileptiform discharges is modestly delayed in slices from ovariectomized rats replaced with physiologically relevant doses of EB, but the number of discharges is not affected.
results demonstrated that HSD17B1 expression and its ability to convert the weak estrogen E1 to the more potent E2 can be associated with DNA methylation in the 5' flanking region in GC cells.
Based on the data we propose that the Hsd17b1 gene includes a regulatory element controlling Naglu expression and the metabolic phenotype in mice lacking the Hsd17b1 genomic region is caused by the reduced expression of Naglu rather than the lack of Hsd17b1.
Mammary-restricted HSD17B1 expression induced lesions at the sites of ducts and alveoli, accompanied by peri- and intraductal inflammation and disruption of the myoepithelial cell layer.
These results revealed a novel role for HSD17B1 in the control of spermatogenesis and male fertility, and that Sertoli cells significantly contribute to steroid synthesis in the testis.
This study indicates that HSD17B1 is a key enzyme in ovarian steroidogenesis and has a novel function in initiation and stabilization of pregnancy
cellular localization of 17beta-HSD mRNA type 1 expression in the ovary, testis, skin, prostate and pituitary gland
17beta-HSD tissue distribution was studied in inbred C57BL mice of both sexes.
Androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney.
hydroxysteroid (17beta) dehydrogenase 1 has a role in prenatal masculinization and ovarian benign serous cystadenomas
Urinary catecholamine levels in 11betaHSD2-/- mice were double those in wild-type mice, suggesting that vasoconstriction contributes to the sustained hypertension in this model.
Activin A rapidly regulates Hsd17b1 transcription in gonadotrope and granulosa cells and may thereby regulate local 17beta-estradiol synthesis.
A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.
HSD17B1 gene was significantly associated with litter size in two populations and could be a useful molecular marker in selection for increasing litter size in pigs.
Primary structure of cDNA and gene are here described, as well as regulatuion of promoter.
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
, 17-beta-hydroxysteroid dehydrogenase type 1
, 20 alpha-hydroxysteroid dehydrogenase
, estradiol 17-beta-dehydrogenase 1
, estradiol 17-beta-dehydrogenase-1
, hydroxysteroid (17-beta) dehydrogenase 1 isoform
, placental 17-beta-hydroxysteroid dehydrogenase
, short chain dehydrogenase/reductase family 28CE, member 1
, Hydroxysteroid dehydrogenase 17 beta, type 1
, 17-beta hydroxysteroid dehydrogenase
, zf 1.2
, 17-beta-dehydrogenase 1
, 17beta-hydroxysteroid dehydrogenase type 1