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anti-Mouse (Murine) POMC Antibodies:
anti-Human POMC Antibodies:
anti-Rat (Rattus) POMC Antibodies:
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Human Polyclonal POMC Primary Antibody for ELISA, IHC - ABIN250413
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... in The Journal of physiology 2005
Show all 6 Pubmed References
Human Polyclonal POMC Primary Antibody for FACS, IF (p) - ABIN673209
Chao, Lu, Lee, Chen, Wang, Yang, Cheng, Liao, Ro: Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury. in PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal POMC Primary Antibody for FACS - ABIN2178604
Xie, Wang, Li, Chao, Yue: Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation. in Neurochemical research 2016
Show all 2 Pubmed References
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (show AGRP Antibodies) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Selenoprotein T (show SELT Antibodies) is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ACTH secretion.
Study shows that alpha melanocyte stimulating hormone and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (show CEBPB Antibodies) negative transcription in mice adipose tissue.
Our findings demonstrate alphaMSH plays a key role in the prevention of adipose inflammation and inflammatory diseases by down-regulating Akt (show AKT1 Antibodies)/JNK (show MAPK8 Antibodies) signal pathway and negatively interacting with FoxOs, which brings up alphaMSH as a novel candidate factor in the adipose anti-inflammation process in obesity.
Data indicate the regulation of energy balance in BMPR1A (show BMPR1A Antibodies)-mediated appetite regulation in POMC neurons.
POMC and AgRP (show AGRP Antibodies) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (show KISS1 Antibodies)(ARC (show NOL3 Antibodies)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC/MC4R (show MC4R Antibodies) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (show AGRP Antibodies) to POMC neuron GABA connectivity depends on the state of AgRP (show AGRP Antibodies) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (show LEP Antibodies) sensitivity and glucose sensing of POMC neurons.
In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC (show HSPG2 Antibodies) pathway, employing PPARgamma (show PPARG Antibodies) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
The human beta-endorphin amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM (show CYLD Antibodies) analyses.
POMC and MC1R (show MSHR Antibodies) were significantly lower in vitiligo (show MITF Antibodies) lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
POMC has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1 (show E2F1 Antibodies)-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53 (show TP53 Antibodies)/POMC/Galphas (show GNAS Antibodies)/SASH1 (show SASH1 Antibodies) autoregulatory positive feedback loop is regulated by SASH1 (show SASH1 Antibodies) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (show FN1 Antibodies) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (show TNF Antibodies), IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (show POU1F1 Antibodies), SF-1 (show NR5A1 Antibodies), and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R Antibodies)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (show APOE Antibodies)) and agouti-related protein (AGRP (show AGRP Antibodies)) with obesity in the North Indian population.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (show PENK Antibodies)) and prodynorphin (PDYN (show PDYN Antibodies)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (show CRH Antibodies) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (show GJA1 Antibodies) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (show PHB2 Antibodies); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2