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Independent double-stranded RNA interference lines displaying distinct MAP1A levels demonstrated that the extent of the developmental defect specifically depends on the concentration of MAP1A.
Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain.
Mutant mice lacking MAP1A exhibited reduced synaptic plasticity.
Although MAP1A and MAP1B protein levels are not affected in the tulp1-/- retina, they are no longer localized to the outer segment of photoreceptors.
The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A, MAP1B, and MAP1S) and alpha1-syntrophin is direct and occurs through the pleckstrin homology domain 2 (PH2).
It was demonstrated that the gene Mtap1a modifies retinal degeneration in Tub(tub/tub) and Tulp1(tm1Pjn/tm1Pjn) mice.
Data indicate that protective alleles of Mtap1a are not sufficient to rescue DW/J-Pou1f1dw/dw mutant hearing.
Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).
Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells.
Microtubule-associated protein light chain 2 interacts with the intracellular C-terminal tail of stargazin.
there is a novel interaction between the C-terminal tail of the BKCa channel and the light chain of MAP1A, which enables channel association with and modulation by the cytoskeleton
MAP1A functions to maintain the neuronal microtubule network in the brain and mutations cause Purkinje cell degeneration.
results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
a novel protein-binding partner for EPAC1 and EPAC2, light chain 2 of MAP1A (microtubule-associated protein 1A)
MAP1A LC2 is a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms
Complexes (MAP1B heavy chain-MAP1A light chain) form through interaction of homologous domains conserved in heavy and light chains of MAP1A and MAP1B. Conserved domains of the MAP1A and MAP1B light chains account for formation of light chain heterodimers.
postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.
, microtubule-associated protein 1A
, methionine aminopeptidase
, modifier of tubby hearing 1
, proliferation-related protein p80