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polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 ELISA Kits) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH ELISA Kits)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC ELISA Kits) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 ELISA Kits) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR ELISA Kits) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm (show SHROOM3 ELISA Kits) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (show SHROOM3 ELISA Kits) function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 ELISA Kits) interaction with p115RhoGEF (show ARHGEF1 ELISA Kits) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 ELISA Kits)-kinase membrane localization, AKT (show AKT1 ELISA Kits) signaling, and cytokine (M-CSF (show CSF1R ELISA Kits)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX ELISA Kits)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
we define how ROCK/LIMK (show LIMK1 ELISA Kits) pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (show SNRK ELISA Kits) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 ELISA Kits), which influenced Ras Homology Family Member A (show CXCL14 ELISA Kits) (RhoA (show RHOA ELISA Kits)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 ELISA Kits)).
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP ELISA Kits)-133a expression leading to an increase in RhoA (show RHOA ELISA Kits)/Rho kinase (show ROCK2 ELISA Kits) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (show ANXA1 ELISA Kits) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA ELISA Kits)-ROCK signaling pathway
the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A ELISA Kits), which induces GSK-3beta (show GSK3b ELISA Kits) phosphorylation and beta-catenin (show CTNNB1 ELISA Kits) accumulation through RhoA (show RHOA ELISA Kits) and ROCK activation.
Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.
ROCK activation phosphorylated Rac1b (show RAC3 ELISA Kits) at Ser71 and increased reactive oxygen species (ROS (show ROS1 ELISA Kits)) levels by facilitating the interaction between Rac1b (show RAC3 ELISA Kits) and cytochrome c (show CYCS ELISA Kits). Conversely, ROCK inactivation abolished their interaction, concomitant with ROS (show ROS1 ELISA Kits) reduction.
OB-Rb (show LEPR ELISA Kits), RhoA (show RHOA ELISA Kits)/ROCK, PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits), JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) pathways and NF-kB activation are involved in leptin (show LEP ELISA Kits)-induced upA (show PRAP1 ELISA Kits) expression.
data suggests that ROCK1 may serve as a potential therapeutic target to enhance current treatment regimens for pancreatic cancer
Genetic variant in ROCK1 gene is associated with progression of prostate cancer.
Results showed that ROCK1 gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 (show ROCK2 ELISA Kits) gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (show PRPH2 ELISA Kits)), and that they could be a risk factor for development of neonatal RDS (show PRPH2 ELISA Kits).
Despite sharing the catalytic domain with ROCK2 (show ROCK2 ELISA Kits), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
RhoA (show RHOA ELISA Kits)/ROCK and Raf-1 (show RAF1 ELISA Kits)/CK2 (show CSNK2A1 ELISA Kits) pathway are responsible for TNF-alpha (show TNF ELISA Kits)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM ELISA Kits) cytoskeleton.
High ROCK1 expression is associated with Clear cell renal cell carcinoma.
Results indicate that ROCK1 and ROCK2 (show ROCK2 ELISA Kits) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 ELISA Kits)/cofilin (show CFL1 ELISA Kits) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 ELISA Kits) phosphorylation and MMP13 (show MMP13 ELISA Kits) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA ELISA Kits)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 ELISA Kits) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1