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Human TUBA1B Protein expressed in Wheat germ - ABIN1324106
Bye, Høydal, Catalucci, Langaas, Kemi, Beisvag, Koch, Britton, Ellingsen, Wisløff: Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. in Physiological genomics 2008
Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin.
The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells.
TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis.
Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells.
Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia.
NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2.
Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function.
Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma.
ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation
TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types.
the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin.
Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo.
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
increased levels in paclitaxel-resistant breast cancer cells
Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection.
accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility
N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin]
mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (tumor necrosis factor receptor-associated protein1), hnRNPM4 (heterogeneous nuclear ribonucleoprotein M4), Hsp70 and Hsp60 (heat shock proteins 70 and 60), and alpha-tubulin
These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable
The molecular interaction between alpha-synuclein and tubulin was confirmed by GST pull-down assay and co-immunoprecipitation.
These results suggest that tuba1a-expressing progenitors contribute to multiple cell lineages during development and that tuba1a-expressing Muller glia are retinal progenitors in the adult.
These results suggest tuba1a expression is necessary for CNS development and regeneration and that KLF6a and 7a mediate their effects, at least in part, via transcriptional control of tuba1a promoter activity.
Wild-type 1.696 kb & mutant promoters w/o E-box &/or HD sequences had similar activity in developing retina. In mature retina, mutant promoter activity was less. E-box & HD sequences were needed during optic nerve regeneration, but not for retinal injury.
Unambiguous identification of novel glutamylation sites E441 and E443 in mouse brain Tuba1a and Tuba1b.
Binding to the outside surface of the microtubule could facilitate access of tubulin acetyltransferase to its luminal site of action if microtubules undergo lateral opening between protofilaments
Results describe the expression pattern of acetylated alpha-tubulin at different stages of testis development confirm that only Ac-alpha-Tu is specific to germ cells.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
, tubulin alpha-1B chain
, tubulin alpha-2 chain
, alpha tubulin
, alpha-tubulin ubiquitous
, tubulin K-alpha-1
, tubulin alpha-ubiquitous chain
, tubulin, alpha, ubiquitous
, tubulin alpha-1C chain
, tubulin, alpha 1
, alpha-tubulin isotype M-alpha-2
, tubulin, alpha 2
, tubulin alpha 3
, tubulin, alpha 1b
, tubulin alpha-1B chain-like
, tubulin alpha chain
, Alpha-tubulin 1
, Alpha-tubulin I
, Tubulin alpha-1 chain
, Tubulin alpha-1A chain
, alpha-tubulin I
, Alpha-tubulin ubiquitous
, Tubulin K-alpha-1
, Tubulin alpha-ubiquitous chain