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Data provide evidence for a role of TUBA8 in hepatic fibrogenesis and malignancies making it a novel player in non-alcoholic steatohepatitis and hepatocellular carcinoma pathology.
Mistargeting of peroxisomal EHHADH (show EHHADH Proteins) disrupts mitochondrial metabolism and leads to renal Fanconi's syndrome; this indicates a central role of mitochondria in proximal tubular function.
TUBA8 can play a role in the regulation of cell growth, proliferation, and cell migration in a cell-specific manner in vitro.
TUBA8 is expressed at low levels in the developing human brain.
Mutation of the variant alpha-tubulin (show TUBA4A Proteins) TUBA8 results in polymicrogyria with optic nerve hypoplasia.
Tuba8 is expressed at low levels in the developing mouse brain.
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene.
alpha 4 tubulin
, tubulin alpha-4 chain
, tubulin, alpha 8
, tubulin alpha chain-like 2
, tubulin alpha-8 chain
, alpha tubulin 8
, alpha-tubulin 8
, 3,2-trans-enoyl-CoA isomerase
, L-3-hydroxyacyl-CoA dehydrogenase
, L-bifunctional protein, peroxisomal
, enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
, peroxisomal bifunctional enzyme
, peroxisomal enoyl-CoA hydratase
, tubulin alpha 8 L homeolog