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Data provide evidence for a role of TUBA8 in hepatic fibrogenesis and malignancies making it a novel player in non-alcoholic steatohepatitis and hepatocellular carcinoma pathology.
TUBA8 can play a role in the regulation of cell growth, proliferation, and cell migration in a cell-specific manner in vitro.
TUBA8 is expressed at low levels in the developing human brain.
Mutation of the variant alpha-tubulin (show TUBA4A Proteins) TUBA8 results in polymicrogyria with optic nerve hypoplasia.
Tuba8 is expressed at low levels in the developing mouse brain.
This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants.
alpha 4 tubulin
, tubulin alpha-4 chain
, tubulin, alpha 8
, tubulin alpha chain-like 2
, tubulin alpha-8 chain
, alpha tubulin 8
, alpha-tubulin 8
, tubulin alpha 8 L homeolog