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anti-Human TUBB1 Antibodies:
anti-Mouse (Murine) TUBB1 Antibodies:
anti-Rat (Rattus) TUBB1 Antibodies:
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Mouse (Murine) Polyclonal TUBB1 Primary Antibody for ICC, IHC - ABIN1860884
Zhao, Li, Han, Yue, Shi, Wang, Guo, Lu: DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. in Free radical biology & medicine 2016
Neonatal platelets exhibit low levels of the Stx11 (show STX11 Antibodies)-Munc18b (show STXBP2 Antibodies) complex (essential component of the SNARE (show NAPA Antibodies) machinery) and of beta1-tubulin (show TUBB Antibodies). These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion.
novel DCX (show DCX Antibodies) mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria
Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin (show TUBB Antibodies) defect.
TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior.
Data indicate that ABCB1 (show ABCB1 Antibodies) protein, beta tubulin (show TUBB Antibodies) I and III (betaI, and betaIII tubulin (show TUBB3 Antibodies)) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer.
TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.
our findings define beta-tubulin (show TUBB Antibodies) VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs
homozygous status of P43 (show AIMP1 Antibodies) genetic polymorphism causes alterations in platelet ultrastructure
Studies show that BFBTS bound and modified beta-tubulin (show TUBB Antibodies) at residue Cys12, forming beta-tubulin (show TUBB Antibodies)-SS-fluorobenzyl.
SLPI (show SLPI Antibodies) localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin (show TUBB Antibodies).
RanBP10 (show RANBP10 Antibodies) inhibits premature microtubule polymerization of beta1-tubulin (show TUBB Antibodies) and plays a pivotal role in thrombus stabilization.
The hematopoietic-specific Hbeta1 (show KCNMB1 Antibodies) tubulin (show TUBB Antibodies) isotype naturally encodes Ibeta236 and is insensitive to 2-methoxyestradiol.
findings highlight the essential requirements of the megakaryocyte/platelet-restricted beta1-tubulin (show TUBB Antibodies) isoform in platelet structure
The conserved four-helix bundle of c-Cbl's tyrosine kinase (show TYRO3 Antibodies) binding domain bound to beta-tubulin (show TUBB Antibodies), and both c-Cbl (show CBL Antibodies) and Cbl-b displaced HDAC6 (show HDAC6 Antibodies).
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
beta tubulin 1, class VI
, class VI beta-tubulin
, tubulin beta-1 chain
, beta-tubulin class-VI
, tubulin beta-6 chain
, tubulin, beta 3
, Tubulin beta-1 chain
, tubulin, beta 1
, tubulin, beta family 1
, tubulin beta-1 chain-like