Browse our ABAT Proteins (ABAT)

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

• 4-aminobutyrate aminotransferase (ABAT)
• 4-aminobutyrate aminotransferase (abat)
• 4-aminobutyrate--2-oxoglutarate transaminase (gabT)
• GABA aminotransferase PLP-dependent PuuE (puuE)
• 4-aminobutyrate aminotransferase (gabT-1)
• Show all gene names
• 4-aminobutyrate aminotransferase (gabT-2)
• 4-aminobutyrate aminotransferase (gabT-3)
• 4-aminobutyrate aminotransferase (gabT)
• 4-aminobutyrate aminotransferase (CNE01830)
• 4-aminobutyrate aminotransferase (Mmwyl1_0047)
• 4-aminobutyrate aminotransferase, mitochondrial (CpipJ_CPIJ008729)
• aspartate aminotransferase family protein (KCR_RS04555)
• 4-aminobutyrate aminotransferase (Bcenmc03_4909)
• 4-aminobutyrate aminotransferase (Hden_0972)
• 4-aminobutyrate aminotransferase (Dbac_2000)
• 4-aminobutyrate aminotransferase (Mesil_2400)
• 4-aminobutyrate aminotransferase (Trad_0121)
• 4-aminobutyrate aminotransferase S homeolog (abat.S)
• 4-aminobutyrate aminotransferase (Abat)

• 9630038C02Rik protein
• AI255750 protein
• BA0325 protein
• beta-AlaAT protein
• cb880 protein
• Show all synonym aliases
• ENSMUSG00000051226 protein
• fj82a01 protein
• GABA-AT protein
• GABA-T protein
• Gabaat protein
• Gabat protein
• Gm9851 protein
• I54 protein
• L-AIBAT protein
• Laibat protein
• NPD009 protein
• PSPTO0259 protein
• PSPTO0301 protein
• PSPTO1890 protein
• wu:fj82a01 protein
• X61497 protein

4-aminobutyrate aminotransferase, mitochondrial , GABA-T , 4-aminobutyrate aminotransferase , (S)-3-amino-2-methylpropionate transaminase , 4-aminobutyrate transaminase , GABA aminotransferase , GABA transaminase , GABA transferase , gamma-amino-N-butyrate transaminase , GABA-AT , L-AIBAT , beta-alanine oxoglutarate aminotransferase