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Browse our ABAT Proteins (ABAT)

Full name:: 4-Aminobutyrate Aminotransferase Proteins (ABAT)

On www.antibodies-online.com are 13 4-Aminobutyrate Aminotransferase (ABAT) Proteins from 6 different suppliers available. Additionally we are shipping ABAT Antibodies (88) and and many more products for this protein. A total of 108 ABAT products are currently listed.

Synonyms:: 9630038C02Rik, AI255750, BA0325, beta-AlaAT, cb880, ENSMUSG00000051226, fj82a01, GABA-AT, GABA-T, Gabaat, Gabat, Gm9851, I54, L-AIBAT, Laibat, NPD009, PSPTO0259, PSPTO0301, PSPTO1890, wu:fj82a01, X61497

list all proteins	Gene Name	GeneID	UniProt
	ABAT	18	P80404
	ABAT	268860	P61922
	ABAT	81632	P50554
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ABAT Proteins (ABAT) by Origin

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Relevant Pathways for ABAT Proteins

Monocarboxylic Acid Catabolic Process

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More Proteins for ABAT Interaction Partners

Human 4-Aminobutyrate Aminotransferase (ABAT) interaction partners

ABAT SNP rs1641025 is a potential candidate locus for responsiveness to opioid analgesics in patients with cancer pain.
This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance.
A-to-G transition at nucleotide 754 of the human ABAT gene identified in lymphoblast cDNA (c.754A>G) results in substitution of an invariant arginine at amino acid 220 by lysine (p.Arg220Lys). This point mutation results in destabilization of the binding of pyridoxal-5'-phosphate to GABA-transaminase (required for transamination of GABA to succinic semialdehyde) and thus results in GABA-transaminase deficiency.
Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders.
direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control in gastro esophageal reflux disease
excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report]
Marked differences in platelet uptake of GABA and activity of catabolic enzyme GABA-T between patients with generalized and localization-related epileptic syndromes. May indicate an impairment in function of brain GABAergic systems.
results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT
lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP at the active site
Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A and ABAT.

Mouse (Murine) 4-Aminobutyrate Aminotransferase (ABAT) interaction partners

These findings have provided underlying molecular details for the aggressive behavior of basal-like breast cancer (BLBC). The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca(2+)-NFAT1 axis.
Propionate-mediated inhibition of neuronal GABA transaminase, an enzyme of the inner mitochondrial membrane, indicates entry of propionate into neuronal mitochondria.Propionate-induced inhibition of energy metabolism in GABAergic neurons may render the striatum, in which >90% of the neurons are GABAergic, particularly vulnerable to degeneration in propionic acidemia

ABAT Protein Profile

Protein Summary

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Alternative names and synonyms associated with ABAT

4-aminobutyrate aminotransferase (ABAT)
4-aminobutyrate aminotransferase (abat)
4-aminobutyrate--2-oxoglutarate transaminase (gabT)
GABA aminotransferase PLP-dependent PuuE (puuE)
4-aminobutyrate aminotransferase (gabT-1)
4-aminobutyrate aminotransferase (gabT-2)
4-aminobutyrate aminotransferase (gabT-3)
4-aminobutyrate aminotransferase (gabT)
4-aminobutyrate aminotransferase (CNE01830)
4-aminobutyrate aminotransferase (Mmwyl1_0047)
4-aminobutyrate aminotransferase, mitochondrial (CpipJ_CPIJ008729)
aspartate aminotransferase family protein (KCR_RS04555)
4-aminobutyrate aminotransferase (Bcenmc03_4909)
4-aminobutyrate aminotransferase (Hden_0972)
4-aminobutyrate aminotransferase (Dbac_2000)
4-aminobutyrate aminotransferase (Mesil_2400)
4-aminobutyrate aminotransferase (Trad_0121)
4-aminobutyrate aminotransferase S homeolog (abat.S)
4-aminobutyrate aminotransferase (Abat)

9630038C02Rik protein
AI255750 protein
BA0325 protein
beta-AlaAT protein
cb880 protein
ENSMUSG00000051226 protein
fj82a01 protein
GABA-AT protein
GABA-T protein
Gabaat protein
Gabat protein
Gm9851 protein
I54 protein
L-AIBAT protein
Laibat protein
NPD009 protein
PSPTO0259 protein
PSPTO0301 protein
PSPTO1890 protein
wu:fj82a01 protein
X61497 protein

Protein level used designations for ABAT

4-aminobutyrate aminotransferase, mitochondrial , GABA-T , 4-aminobutyrate aminotransferase , (S)-3-amino-2-methylpropionate transaminase , 4-aminobutyrate transaminase , GABA aminotransferase , GABA transaminase , GABA transferase , gamma-amino-N-butyrate transaminase , GABA-AT , L-AIBAT , beta-alanine oxoglutarate aminotransferase

GENE ID	SPECIES
100051470	Equus caballus
378968	Danio rerio
416642	Gallus gallus
453903	Pan troglodytes
1086502	Bacillus anthracis str. Ames
1169096	Shewanella oneidensis MR-1
1181867	Pseudomonas syringae pv. tomato str. DC3000
1181910	Pseudomonas syringae pv. tomato str. DC3000
1183535	Pseudomonas syringae pv. tomato str. DC3000
3196857	Ruegeria pomeroyi DSS-3
3257776	Cryptococcus neoformans var. neoformans JEC21
5367528	Marinomonas sp. MWYL1
6041096	Culex quinquefasciatus
6094157	Candidatus Korarchaeum cryptofilum OPF8
6127721	Burkholderia cenocepacia MC0-3
9386856	Hyphomicrobium denitrificans ATCC 51888
100174312	Pongo abelii
1064855	Tropheryma whipplei TW08/27
8377675	Desulfomicrobium baculatum DSM 4028
9251916	Meiothermus silvanus DSM 9946
9279090	Truepera radiovictrix DSM 17093
398751	Xenopus laevis
18	Homo sapiens
397500	Sus scrofa
280969	Bos taurus
268860	Mus musculus
81632	Rattus norvegicus
479856	Canis lupus familiaris

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