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anti-Mouse (Murine) FAAH Antibodies:
anti-Human FAAH Antibodies:
anti-Rat (Rattus) FAAH Antibodies:
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Human Monoclonal FAAH Primary Antibody for ELISA, WB - ABIN560832
McFarland, Bardell, Yates, Placzek, Barker: RNA interference-mediated knockdown of dynamin 2 reduces endocannabinoid uptake into neuronal dCAD cells. in Molecular pharmacology 2008
Show all 3 Pubmed References
Human Monoclonal FAAH Primary Antibody for ELISA, WB - ABIN396493
Fügedi, Molnár, Rigó, Schönléber, Kovalszky, Molvarec: Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study. in BMC pregnancy and childbirth 2015
These data demonstrate that FAAH activity is required for leptin's hypophagic effects
The purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in Operant sensation seeking utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice.
Dual FAAH and TRPV1 blockage inhibits contextual fear memory.
Results suggest that fatty acid amide hydrolase (FAAH)-regulated N-acyl-taurines (NATs) signaling as a lipid-based mechanism of wound-healing control in mammalian skin, which might be targeted for chronic wound therapy.
N-arachidonoyl ethanolamine and 2-arachidonoyl glycerol hydrolyzing enzymes, FAAH and MAGL, and the CB1 receptor link the endocannabinoid system to broader lipid signaling networks in contrasting ways, potentially altering neurotransmission and behavior independently of cannabinoid receptor signaling.
Both inhibitors reduced several markers of macrophage activation, such as mRNA expression of inflammatory mediators, as well as cytokine and prostaglandin production, with however some differences between FAAH and NAAA inhibition. Our results support an important role for inhibition of NAE hydrolysis and NAAA inhibition in particular in controlling macrophage activation, and thus inflammation.
Inactivation of FAAH, the main degrading enzyme of anandamide and similar endocannabinoids, could lead to an increased decidual endocannabinoid tone with embryotoxic effects.
genetic deletion of FAAH may predispose animals to increased sensitivity to certain types of pain.
Impaired neurogenesis by HIV-1-Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme
Study identified FAAH as a novel player in the pathogenesis of lupus
Basal concentrations of anandamide was greater, and the severity of cystitis was reduced FAAH KO mice. Cystitis-associated increased peripheral sensitivity and enhanced bladder activity were attenuated in FAAH KO mice.
in FAAH(-/-) animals the number of microglia and the ratio of activated microglia and IL-1beta level were already higher in young animals
Results demonstrate that the supra-spinally-located FAAH enzyme is necessary for the analgesic action of paracetamol.
Data suggest that multitarget FAAH/Cox blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase/cyclooxygenases (FAAH, Cox-1, and Cox-2) are overactive.
our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response.
FLAT does not serve as a global intracellular AEA carrier
FAAH inhibitors provide a new class of anti-spastic agents that may have utility in treating spasticity in multiple sclerosis.
FAAH is required for chronic stress to induce hyperactivity and structural amygdala remodeling. FAAH-mediated decreases in arachidonylethanolamine signaling after chronic stress. This loss is functionally relevant to the effects of chronic stress.
The endotoxin induced decrease in peripheral blood mononuclear cell FAAH activity is reversed by progesterone in a receptor-mediated fashion.
Data suggest that FAAH structure is modulated by membranes; FAAH preferentially binds to membranes containing both endocannabinoid/anandamide (AEA) and cholesterol; cholesterol modulates FAAH activity; FAAH co-localizes with AEA and cholesterol.
the interaction between NAPE-PLD rs12540583 and FAAH rs324420, rs2295633 and rs6429600 is associated with schizophrenia.
This study demonstrated that a significant association was observed between FAAH SNP genotype and self-report pain measures, mechanical and cold pain sensitivity among LBP participants.
The FAAH levels were lower in the polycystic ovary syndrome(PCOS) group than the non-PCOS group. FAAH levels in secretory phases were significantly elevated compared to menstrual and proliferative phase. Dysregulation of the endocannabinoid system may result in PCOS.
FAAH variants have shown a robust gene-environment interaction, namely, significantly higher anxiety and depression scores were exhibited by individuals carrying the A allele
High FAAH expression is associated with lung neoplasms.
study demonstrates a dose-dependent relationship between chronic cannabis use and reported sleep quality, independent of abstinence length. Furthermore, it provides novel evidence that depressive symptoms mediate the relationship between FAAH genotype and sleep quality in humans.
FAAH was significantly associated with DSM-5 cannabis use disorder group count (DSM-5 CUD) using a gene-based test (p = 0.0035). This association survived Bonferroni correction for multiple testing at p < 0.004. Post hoc analyses suggested this association was driven by two common (minor allele frequency >5%) SNPs in moderate linkage disequilibrium, rs324420 and rs4141964, at p = 0.0014 and p = 0.0023, respectively.
We first report loss-of-function mutations in DGAT2 and FAAH in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity.
This study suggests that interactions between anandamide and CRF1 represent a fundamental molecular mechanism regulating amygdala function and anxiety.
In cannabis users, fatty acid amide hydrolase binding was significantly lower across the brain regions examined than in matched control subjects. Lower binding was negatively correlated with cannabinoid concentrations in blood and urine and was associated with higher trait impulsiveness.
We investigated the relationship between variation in the CNR1, CNR2, and FAAH genes and change in primary anxiety disorder severity. Five SNPs were nominally associated with a poorer treatment response (rs806365 [CNR1]; rs2501431 [CNR2]; rs2070956 [CNR2]; rs7769940 [CNR1]; rs2209172 [FAAH]) and one with a more favorable response (rs6928813 [CNR1]).
C385A variation modulates stress responses in subjects with posttraumatic stress disorder and alcohol dependence
REVIEW: role in pain and pain treatment
the presence and differential distribution of fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGLL) in relation to CB1 during the maturation of human oocytes, was investigated.
fatty acid amide hydrolase inhibition exerts cutaneous anti-inflammatory effects
In transgenic mice, a direct involvement of the human FAAH C385A SNP was associated with alcohol "binge" drinking.
Results suggest that carriers of FAAH A allele are at increased risk of Myocardial Infarction.
FAAH gene variation was shown to associate with cold pain sensitivity with P129T/rs324420 being the most likely causal variant as it is known to reduce the FAAH enzyme activity.
Data suggest that subjects who are carriers of minor allele (A) at missense mutation rs324420 in FAAH benefit from increased consumption of oleic and docosahexaenoic acids in dietary treatment of abdominal obesity.
Specific FAAH polymorphisms are associated with refractory postoperative nausea and vomiting , opioid-related respiratory depression, and prolonged PACU stay due to opioid adverse effects in white children undergoing tonsillectomy.
This study showed that FAAH gene expression was similar among high, medium and low fertile bulls and that CB1 expression was positively and significantly related to bull fertility.
our study demonstrates the feasibility of using an unbiased chemical genetic approach to identify new pharmacological tools for manipulating FAAH- and NAE-mediated physiological processes in plants.
AtFAAH is one, but not the only, modulator of endogenous N-Acylethanolamines (NAE) levels in plants, and that NAE depletion likely participates in the regulation of plant growth [fatty acid amide hydrolase] [AtFAAH]
Overexpression of AtFAAH inhibits innate immunity against Pseudomonas syringae in Arabidopsis, and plants had lower amounts of jasmonic acid, abscisic acid, and salicylic acid.
AtFAAH influences plant growth and interacts with ABA signaling and plant defense through distinctly different mechanisms
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.
, anandamide amidohydrolase 1
, fatty acid amide hydrolase protein
, fatty-acid amide hydrolase 1
, oleamide hydrolase 1
, fatty acid amide hydrolase
, hypothetical protein LOC569067
, fatty-acid amide hydrolase
, fatty-acid amide hydrolase 1-like
, fatty acid amide hydrolase, gene 3