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Buffalo (Bubalus) Polyclonal CHGA Primary Antibody for IEM, ICC - ABIN617895
Poulsom, Chinery, Sarraf, Lalani, Stamp, Elia, Wright: Trefoil peptide expression in intestinal adaptation and renewal. in Scandinavian journal of gastroenterology. Supplement 1992
Show all 174 Pubmed References
Buffalo (Bubalus) Polyclonal CHGA Primary Antibody for IEM, ICC - ABIN617896
Beham, Schmid, Fletcher, Auböck, Pickel: Malignant paraganglioma of the uterus. in Virchows Archiv. A, Pathological anatomy and histopathology 1992
Show all 36 Pubmed References
Human Polyclonal CHGA Primary Antibody for ICC, IF - ABIN266232
Polyak, Mach, Porvasnik, Dixon, Conlon, Erger, Acosta, Wright, Campbell-Thompson, Zolotukhin, Wasserfall, Mah: Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis. in American journal of physiology. Gastrointestinal and liver physiology 2012
Show all 9 Pubmed References
Human Monoclonal CHGA Primary Antibody for BI, IF - ABIN2689472
Kroon, Martinson, Kadoya, Bang, Kelly, Eliazer, Young, Richardson, Smart, Cunningham, Agulnick, DAmour, Carpenter, Baetge: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. in Nature biotechnology 2008
Show all 5 Pubmed References
Human Polyclonal CHGA Primary Antibody for IF (cc), IF (p) - ABIN669846
Wang, Ahmad, Shah, Sims, Magness, Allbritton: Capture and 3D culture of colonic crypts and colonoids in a microarray platform. in Lab on a chip 2013
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Monoclonal CHGA Primary Antibody for IHC (fro), IHC (p) - ABIN335308
Lloyd, Wilson: Specific endocrine tissue marker defined by a monoclonal antibody. in Science (New York, N.Y.) 1983
Show all 3 Pubmed References
Human Polyclonal CHGA Primary Antibody for IHC, IHC (p) - ABIN4298354
Marbiah, Harvey, West, Louzolo, Banerjee, Alden, Grigoriadis, Hummerich, Kan, Cai, Bloom, Jat, Collinge, Klöhn: Identification of a gene regulatory network associated with prion replication. in The EMBO journal 2014
Show all 2 Pubmed References
Human Monoclonal CHGA Primary Antibody for ELISA, WB - ABIN1724756
El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease. in Journal of endocrinological investigation 2010
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Human Monoclonal CHGA Primary Antibody for ICC, FACS - ABIN1724755
Mergler, Skrzypski, Sassek, Pietrzak, Pucci, Wiedenmann, Strowski: Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells. in Cellular signalling 2011
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Human Monoclonal CHGA Primary Antibody for ELISA, FACS - ABIN4298377
Sampedro-Núñez, Luque, Ramos-Levi, Gahete, Serrano-Somavilla, Villa-Osaba, Adrados, Ibáñez-Costa, Martín-Pérez, Culler, Marazuela, Castaño: Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors. in Oncotarget 2016
Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Systemic CST (show CORT Antibodies) knockout (CST (show CORT Antibodies)-KO) mice on normal chow diet (NCD) ate more food, gained weight, and displayed elevated blood glucose and insulin (show INS Antibodies) levels.
CgA (show CGA Antibodies) is an important regulator for coordination of mitochondrial dynamics, secretory vesicular quanta and glucose-stimulated insulin (show INS Antibodies) secretion for optimal secretory functioning of beta-cells, suggesting a strong, CgA (show CGA Antibodies)-dependent positive link between mitochondrial fusion and glucose-stimulated insulin (show INS Antibodies) secretion
Increased myocardial CgA (show CGA Antibodies) glycosylation and impaired CgA (show CGA Antibodies) processing to catestatin in heart failure be considered detrimental because CST (show CORT Antibodies) reduces diastolic Ca2 (show CA2 Antibodies)+ leak via direct CaMKIIdelta inhibition.
performance of CgA (show CGA Antibodies)-deficient Chga-KO mice in treadmill exercise was impaired. CgA (show CGA Antibodies) deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (show GYS1 Antibodies) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (show LEP Antibodies) and CST (show CORT Antibodies) modulation of SGLT1 (show SLC5A1 Antibodies) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (show IAPP Antibodies) precursor (IAPP (show IAPP Antibodies)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Antibodies)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Results suggest that severe atopic dermatitis is associated with higher stress levels. Simple salivary CgA (show CGA Antibodies) measurements may be useful as an objective assessment of patient stress.
cardiac atria express but do not secrete CgA (show CGA Antibodies) into circulation in patients with atrial disease
These results suggest that circulating full-length CgA (show CGA Antibodies) is an important inhibitor of angiogenesis and tumor growth, and that cleavage of its C-terminal region markedly reduces its activity. Pathophysiological changes in CgA (show CGA Antibodies) blood levels and/or its fragmentation might regulate disease progression in cancer patients.
Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide (show BNP Antibodies)) and CST (show GAL3ST1 Antibodies) levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA (show CGA Antibodies) is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA (show CGA Antibodies) can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B (show CHGB Antibodies) may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (show CHGB Antibodies)), synaptophysin (show SYP Antibodies), and insulin (show INS Antibodies) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (show BTG1 Antibodies)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (show AGTR2 Antibodies).
chromogranin A has a role in the IP(3)-mediated Ca(2 (show CA2 Antibodies)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (show CA2 Antibodies)+ channel (InsP3R (show ITPR1 Antibodies))in the Ca2 (show CA2 Antibodies)+-dependent ciliary movement
involvement of CGA (show CGA Antibodies) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 Antibodies)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I