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Buffalo (Bubalus) Polyclonal CHGA Primary Antibody for IEM, ICC - ABIN617895
Poulsom, Chinery, Sarraf, Lalani, Stamp, Elia, Wright: Trefoil peptide expression in intestinal adaptation and renewal. in Scandinavian journal of gastroenterology. Supplement 1992
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Buffalo (Bubalus) Polyclonal CHGA Primary Antibody for IEM, ICC - ABIN617896
Beham, Schmid, Fletcher, Auböck, Pickel: Malignant paraganglioma of the uterus. in Virchows Archiv. A, Pathological anatomy and histopathology 1992
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Human Polyclonal CHGA Primary Antibody for ICC, IF - ABIN266232
Polyak, Mach, Porvasnik, Dixon, Conlon, Erger, Acosta, Wright, Campbell-Thompson, Zolotukhin, Wasserfall, Mah: Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis. in American journal of physiology. Gastrointestinal and liver physiology 2012
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Human Polyclonal CHGA Primary Antibody for IF (cc), IF (p) - ABIN669846
Wang, Ahmad, Shah, Sims, Magness, Allbritton: Capture and 3D culture of colonic crypts and colonoids in a microarray platform. in Lab on a chip 2013
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Human Monoclonal CHGA Primary Antibody for BI, IF - ABIN2689472
Kroon, Martinson, Kadoya, Bang, Kelly, Eliazer, Young, Richardson, Smart, Cunningham, Agulnick, DAmour, Carpenter, Baetge: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. in Nature biotechnology 2008
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Monoclonal CHGA Primary Antibody for IHC (fro), IHC (p) - ABIN335308
Lloyd, Wilson: Specific endocrine tissue marker defined by a monoclonal antibody. in Science (New York, N.Y.) 1983
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Human Monoclonal CHGA Primary Antibody for ELISA, FACS - ABIN4298358
Sampedro-Núñez, Luque, Ramos-Levi, Gahete, Serrano-Somavilla, Villa-Osaba, Adrados, Ibáñez-Costa, Martín-Pérez, Culler, Marazuela, Castaño: Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors. in Oncotarget 2016
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Human Monoclonal CHGA Primary Antibody for ELISA, WB - ABIN1724756
El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease. in Journal of endocrinological investigation 2010
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Human Monoclonal CHGA Primary Antibody for ICC, FACS - ABIN1724755
Mergler, Skrzypski, Sassek, Pietrzak, Pucci, Wiedenmann, Strowski: Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells. in Cellular signalling 2011
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Human Polyclonal CHGA Primary Antibody for IHC, IHC (p) - ABIN4298354
Marbiah, Harvey, West, Louzolo, Banerjee, Alden, Grigoriadis, Hummerich, Kan, Cai, Bloom, Jat, Collinge, Klöhn: Identification of a gene regulatory network associated with prion replication. in The EMBO journal 2014
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Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Study using live-cell imaging at single vesicle resolution revealed a normal number of fusion events upon bursts of action potentials in CgA/B-/- neurons. Data indicate that the two chromogranins are dispensable for cargo sorting in the regulated secretory pathway and dense-core vesicle in mouse hippocampal neurons.
Data suggest that hybrid insulin peptides (HIPs), formed in insulin-secreting-cells by fusion of insulin C-peptide fragments to peptide fragments of chromogranin A or islet amyloid polypeptide, and reactivity of CD4+-T-lymphocytes to HIPs may act as biomarkers of autoimmunity in type 1 diabetes.
Systemic CST knockout (CST-KO) mice on normal chow diet (NCD) ate more food, gained weight, and displayed elevated blood glucose and insulin levels.
CgA is an important regulator for coordination of mitochondrial dynamics, secretory vesicular quanta and glucose-stimulated insulin secretion for optimal secretory functioning of beta-cells, suggesting a strong, CgA-dependent positive link between mitochondrial fusion and glucose-stimulated insulin secretion
Increased myocardial CgA glycosylation and impaired CgA processing to catestatin in heart failure be considered detrimental because CST reduces diastolic Ca2+ leak via direct CaMKIIdelta inhibition.
performance of CgA-deficient Chga-KO mice in treadmill exercise was impaired. CgA deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin and CST modulation of SGLT1 expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8(+) T cells in NOD.beta2m(null).HHD mice.
Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension.
We probed the role of the chromogranin A-derived peptide pancreastatin (PST: CHGA(273-301)) by investigating the effect of diet-induced obesity (DIO) on insulin sensitivity of these mice.
Findings indicate that peptides from the N-terminal region of chromogranin A (ChgA) are able to induce cellular and humoral immune responses in NOD mice.
It is a neuroinflammatory factor,which activates interleukin-1beta in brain microglia.
Chromogranin A contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.
Although chromogranins regulate the amine concentration in chromaffin cell secretory vesicles, they are not completely essential.
serpinin, a novel chromogranin A-derived peptide, is secreted upon stimulation of corticotrophs and plays an important autocrine role in up-regulating protease nexin-1-dependent granule biogenesis
Data indicate that circulating chromogranin A (CgA) has a better overall accuracy in the follow-up setting [Review and Meta-analysis].
Elevated serum CGA was negatively associated with overall survival in men with metastatic castrate resistant prostate cancer. Serum CGA represents a prognostic biomarker that may complement circulating tumor cells enumeration.
Patients with higher catestatin levels developed worse ventricular function during the follow-up period. Single-point catestatin was effective to predict LVEDD change. And concurrently increasing catestatin and NT-proBNP levels predicted the highest risk of LV remodeling. This study suggests an important prognostic information of catestatin on LV remodeling.
CgA and NSE are clinically valuable tumor markers in neuroblastoma and they merit prospective clinical evaluations as such.
Vasostatin-1 is stably overexpressed in serum of patients with ileal and pancreatic neuroendocrine neoplasms.
Results suggest that severe atopic dermatitis is associated with higher stress levels. Simple salivary CgA measurements may be useful as an objective assessment of patient stress.
cardiac atria express but do not secrete CgA into circulation in patients with atrial disease
These results suggest that circulating full-length CgA is an important inhibitor of angiogenesis and tumor growth, and that cleavage of its C-terminal region markedly reduces its activity. Pathophysiological changes in CgA blood levels and/or its fragmentation might regulate disease progression in cancer patients.
Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide) and CST levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
we could provide evidence that established stress-related biomarkers ET-1, MCP-1, CGA were differentially regulated among patients with AF compared to healthy controls.
Combined plasma CgA concentrations and World Health Organization grading may assist in better stratification of PNET patients in terms of the risk of recurrence.
Metastatic castration-resistant prostate cancer patients with an early high CGA rise may demonstrate a subgroup with poor outcome due to underlying small cell/neuroendocrine cell transformation.
genetic association studies in population in India: Data suggest that common polymorphisms (SNPs) in CHGA promoter are associated with cardiometabolic disorders; c-Rel has a role in activating CHGA promoter haplotype 2 (variant T alleles at -1018 and -57 bp) under basal and pathophysiological conditions. (CHGA = chromogranin A; c-Rel = c-Rel proto-oncogene protein)
Multivariate analyses of nonfunctional pancreatic neuroendocrine tumor patients with both grade and CgA recorded found poorly differentiated tumors and very high CgA negatively impacted survival.
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor.
chromogranin A has a role in the IP(3)-mediated Ca(2+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2+ channel (InsP3R)in the Ca2+-dependent ciliary movement
involvement of CGA with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells
Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
Cateslytin adopts a dominant beta-sheet character upon interaction with negatively charged membranes, whereas it is essentially unstructured in water as are most short linear antimicrobial peptides.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I