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Human Follistatin Protein expressed in Escherichia coli (E. coli) - ABIN593426
Li, Shimono, Norioka, Nakano, Okubo, Yagi, Hayashi, Sato, Fujisaki, Hattori, Sugiura, Kimata, Sekiguchi: Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Mouse (Murine) Follistatin Protein expressed in Escherichia coli (E. coli) - ABIN1304431
Ishaq, Schang, Magre, Laverrière, Guillou, Coudouel, Wargnier, Cohen-Tannoudji, Counis: Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice. in Journal of molecular endocrinology 2013
FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
these studies suggest that follistatin expression in invasive breast cancer is unrelated to the disease severity and the risk of recurrence, but is more intense in estrogen receptor -negative tumors
Surface plasmon resonance analysis showed no significant association between FS288 and AMHC , suggesting that FS288 indirectly regulates AMH signaling. Activin A, a direct target of FS288, did not itself induce reporter activity in P19 cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A may influence the response of some cell types to AMH.
results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer
These data indicate that FST is a bona fide metastasis suppressor in this mouse model and support future efforts to develop an FST mimetic to suppress metastatic progression.
These findings indicate that muscle-specific Fst overexpression in pigs enhances skeletal muscle growth, at least partly due to myofiber hypertrophy and providing a promising approach to increase muscle mass in pigs and other livestock.
High follistatin expression is associated with lung adenocarcinoma.
FST and KLK6 may have significance in breast cancer detection
Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB
The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.
Low follistatin expression is associated with liver cirrhosis.
Follistatin levels are associated with circulating leptin levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.
Within the nonalcoholic fatty liver disease group of patients, follistatin was associated with steatohepatitis independently from activin A
annexin A2 but not follistatin is expressed in hepatocellular carcinoma
FST plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function. In terms of diagnosis, prognosis and therapy, FST has shown strong promise
Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women.
Circulating follistatin may be a marker of the glucagon-to-insulin tone on the liver
serum concentrations positively associated with serum free thyroxine levels in hyperthyroid or euthyroid patients
We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung.
changes in Follistatin levels during pregnancy contribute to the control of the activin A system
Two angiogenic factors, follistatin (and HGF) are associated with prognosis in esophageal cancer patients.
Response to selection for increased litter size could not be attributed to effects at the estrogen receptor, retinol-binding protein or follistatin loci.
Data suggest that SMAD4 (SMAD family member 4) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 dependent.
The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease.
A functional role for oocyte-derived follistatin in bovine early embryogenesis.
These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
Uterine Fst-cKO mice demonstrate severe fertility defects and deliver only 2% of the number of pups delivered by control females. In Fst-cKO mice, the uterine luminal epithelium does not respond properly to estrogen and progesterone signals and remains unreceptive to embryo attachment by continuing to proliferate and failing to differentiate.
Data suggest that the level of circulating follistatin is involved in testicular damage due to autoimmune orchitis; these studies were conducted using gene transfer to increase circulating levels of follistatin in experimental model of autoimmune orchitis.
Hypergravity affects follistatin levels in muscle through the vestibular system in mice. Follistatin may play some roles in the interactions between muscle and bone metabolism in response to gravity change.
Fst promotes brown adipocyte characteristics in both white adipose tissue and brown adipose tissue depots in vivo through distinct mechanisms.
Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function.
OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells.
This study assesses the regulation of activin A and follistatin in a murine myocardial ischaemia-reperfusion model.
Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.
follistatin induces hair wave propagation and its level decreases in aging mice.
Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state.
Report role of activin A-myostatin-follistatin system on aging bone and muscle progenitor cells.
Although it is a promising therapeutic tool in chronic or acute inflammatory conditions not caused by virulent pathogens, FS does not seem to increase the resistance to bacterial infections.
Data from transgenic mice suggest that overexpression of follistatin negatively influences bone metabolism decreasing all measured biomechanical strength parameters in developing bone.
These data indicate that the rapid increase in circulating activin A during LPS-induced inflammation is regulated at the posttranscriptional level.
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
We conclude that testosterone stimulation of satellite cell proliferation and myogenic differentiation are associated with up regulation of Fst and inhibition of TGF-beta-signaling.
follistatin stimulated myoblasts to express MyoD, Myf5, and myogenin, which are myogenic transcription factors that promote myogenic differentiation
Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.
fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
, follistatin 1
, activin-binding protein
, follistatin isoform FST317
, follistatin A