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The neonates who had GSTT1 (show GSTT1 Proteins) or GSTM1 polymorphism were associated with an increased risk of being small for gestational age SGA. A combination of the GSTT1 (show GSTT1 Proteins) and GSTM1 null genotype exacerbated the effect of maternal environmental tobacco smoke exposure on SGA more than the presence of either genotype alone (odds ratio=8.90, 95% confidence interval=1.00-79.5).
GSTT1 (show GSTT1 Proteins) and GSTM1 may modulate DNA damage levels of p53 (show TP53 Proteins) gene when exposed to polycyclic aromatic hydrocarbons.
Carriers of GSTM1-null and GSTP1 (show GSTP1 Proteins)-variant genotypes are in increased risk of RCC (show XRCC1 Proteins) development. On the contrary, GSTM1-null genotype is associated with favorable postoperative prognosis in ccRCC.
Suggest that the donors and recipients' GSTM1 polymorphism may be a major risk factor for oxidative stress and delayed graft function in kidney transplant recipients.
The combination of glutathione S-transferase theta 1 (GST T1) null/glutathione S-transferase mu 1 (GST M1) wild genotype was significantly more frequent in diabetic patients than controls, indicating a significantly increased risk of type 1 diabetes mellitus (T1DM).
The Pro198Leu polymorphism (rs1050450) to the selenoprotein glutathione peroxidase 1 (show GPX1 Proteins) gene (GPX1 (show GPX1 Proteins)), and GSTM1 deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations.
This meta-analysis demonstrates that the GSTM1-null, GSTT1 (show GSTT1 Proteins)-null, and GSTM1/GSTT1 (show GSTT1 Proteins) double-null genotypes are associated with increased bladder cancer risk.
the study findings allow us to conclude that the deletion genotypes of GSTM1 and GSTT1 (show GSTT1 Proteins) are associated with infertility in Russian men.
this meta-analysis indicates that the combined effects of the GSTM1 and GSTT1 (show GSTT1 Proteins) polymorphisms are associated with increased lung cancer risk in Asians, Caucasians, and Indians.
Our results suggest that GSTM1 and GSTT1 (show GSTT1 Proteins) gene deletion/null gene polymorphisms are not a key modulators of the risk of developing colorectal cancer in Kashmiri population.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Proteins) regulation: cytochrome CYP2A5, GSTM3 (show GSTM3 Proteins), GSTM1, ENTPD5 (show ENTPD5 Proteins),UDPGDH (show UGDH Proteins), and EPHX1 (show EPHX1 Proteins).
mitochondrial Gstb1 is induced under oxidative stress
the gene (GSTM1) encoding the detoxification enzyme glutathione S-transferase M1 is transcriptionally upregulated by Myb (show MYB Proteins)
The Gstm1 gene was represented by two EST (show MAP3K8 Proteins) clones with similar levels of downregulation.
We overexpressed Hoxa9 (show HOXA9 Proteins) and Meis1 (show MEIS1 Proteins) in primary hematopoietic cells. Arrays identified c-Myb (show MYB Proteins) and a c-Myb (show MYB Proteins) target (Gstm1) among the genes with the strongest response to Hoxa9 (show HOXA9 Proteins)/Meis1 (show MEIS1 Proteins).
Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. In addition, oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
GST HB subunit 4
, GST class-mu 1
, HB subunit 4
, S-(hydroxyalkyl)glutathione lyase
, glutathione S-alkyltransferase
, glutathione S-aralkyltransferase
, glutathione S-aryltransferase
, glutathione S-transferase M1
, glutathione S-transferase Mu 1
, GST 3-3
, GST Yb1
, glutathione S-transferase Yb-1 subunit
, glutathione-S-transferase mu type 1 (Yb1)
, glutathione-S-transferase, mu type 1 (Yb1)
, GST 1-1
, glutathione S-transferase GT8.7
, glutathione-S-transferase, mu 1
, glutathione S-transferase mu 1
, GST Mu I
, GST class-mu
, glutathione S-transferase M2 (muscle)
, glutathione transferase
, glutathione S-transferase mu 2
, glutathione S-transferase, mu 2