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WW3 and WW4 domains of Nedd4-2 are critical for its association with and modulation of the transporter.
study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L and CYP11beta2
Collectively, Nedd4L plays a tumor suppressive role in HCC (show FAM126A Proteins), possibly through triggering MAPK/ERK (show MAPK1 Proteins)-mediated apoptosis, and Nedd4L downregulation may be a potential prognostic biomarker as well as a therapeutic target for HCC (show FAM126A Proteins).
evidence implicating E3 ubiquitin ligase (show MUL1 Proteins) NEDD4L in the pathogeny of periventricular nodular heterotopia
This study demonstrated that it is possible to downregulate Kv1.3 (show KCNA3 Proteins) channel density through activation of an E3 ubiquitin ligase (show MUL1 Proteins) and that inhibition of the protease pathway or mutation of the Nedd4-2 catalytic site prevents Kv1.3 (show KCNA3 Proteins) modulation.
These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (show XBP1 Proteins) and that this is important in the induction of an appropriate autophagic response.
both Nedd4-1 (show NEDD4 Proteins) and Nedd4-2 are important regulators for hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and function
USP36 actions extend beyond TrkA (show NTRK1 Proteins) because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Proteins)/3 channel regulation.
NEDD4L negatively regulates PIK3CA (show PIK3CA Proteins) protein levels via ubiquitination and is required for the maintenance of PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling pathway.
overexpression of miR (show MLXIP Proteins)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Proteins) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Proteins)-93 in lung tumorigenesis and metastasis.
these findings suggest that regulation of Dvl (show DVL2 Proteins) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Proteins)-activated kinase promotes ENaC (show SCNN1A Proteins)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Proteins) by increasing Nedd4-2-dependent ENaC (show SCNN1A Proteins) retrieval from the plasma membrane.
results indicate that AMPK (show PRKAA2 Proteins) inhibits KCNQ1 (show KCNQ1 Proteins) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.
ENaC-beta (show SCNN1B Proteins) regulation that occurs through IKKbeta (show IKBKB Proteins)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Proteins) and protein kinase A target site.
These results suggested that Nedd4-2 with C2 domain might play a pivotal role in cardio-renal associations through post-transcriptional modification of both epithelial sodium channel and cardiac ion channels, which are critical for kidney and heart functions.
Nedd4-2 knockdown ameliorates movement disorders in PD mice.
Tmbim1 promoted the lysosomal degradation of toll-like receptor 4 (show TLR4 Proteins) by cooperating with the ESCRT endosomal sorting complex to facilitate MVB formation, and the ubiquitination of Tmbim1 by the E3 ubiquitin ligase (show MUL1 Proteins) Nedd4l was required for this process.
These results identify NKCC1 (show SLC12A2 Proteins) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Proteins)).
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Proteins)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Proteins) receptor GluA1 (show GRIA1 Proteins) ubiquitination.
These findings elucidate a critical role of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
We identified glutamate (show GRIN1 Proteins) receptor subunit 1 (GluA1 (show GRIA1 Proteins)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2
The short isoform of the ubiquitin ligase (show RNF123 Proteins) NEDD4L is a CREB (show CREB1 Proteins) target gene in hepatocytes.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b