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ABR depletion leads to G2/M accumulation in human embryonic stem cells. Centrosome dynamics and mitotic fidelity are compromised upon ABR depletion. When mitosis progresses without ABR, human embryonic stem cells show a high incidence of aneuploidy.
During vest (show BCR Antibodies)ibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination.
Loss of abr expression causes defects in spine development.
These results identify Abr-regulated CD4 (show CD4 Antibodies)(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice.
Bcr (show BCR Antibodies) and Abr play a critical role in down-regulating hypoxia-induced pulmonary hypertension by deactivating Rac1 (show RAC1 Antibodies).
Abr and Bcr (show BCR Antibodies) play important complementary roles during vestibular morphogenesis
These results identify Abr and Bcr (show BCR Antibodies) as the only GTPase (show RACGAP1 Antibodies)-activating proteins to date that specifically negatively regulate Rac (show AKT1 Antibodies) function in vivo in primary macrophages.
These data show that Abr and Bcr (show BCR Antibodies) normally curb very specific functions of mature tissue innate immune cells.
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene.
active breakpoint cluster region-related protein