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These results suggest that Ect2 plays roles in multiple aspects of DNA damage response.
It was shown that the guanine exchange factors GEF-H1 (show ARHGEF2 Proteins) and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 (show ARHGEF2 Proteins) downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Ect2 may play a role in neuronal differentiation and brain development in vivo.
results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary
indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes
ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation
While the association of ECT2 with the plasma membrane is essential for cytokinesis, our data suggest that ECT2 recruitment to the spindle midzone is insufficient to account for equatorial furrowing and may act redundantly with yet-uncharacterized signals.
Among 518 genes co-expressed with ECT2 in LUAD and 386 genes co-expressed with ECT2 in LUSC, there were only 98 genes in the overlapping cluster
E6AP (show ube3a Proteins) suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 and Rho GTPase (show RACGAP1 Proteins) activity.
Ect2 regulates rRNA synthesis through a PKCiota-Ect2-Rac1-NPM (show NPM1 Proteins) signaling axis that is required for lung tumorigenesis.
Data suggest that the expression of epithelial cell transforming sequence 2 oncogene (ECT2) can serve as an alternative measurement that can compensate for the inadequacy of the current carcinoembryonic antigen (CEA (show CEACAM5 Proteins)) test in the diagnosis and monitoring of colorectal cancer patients.
Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and Aurora kinase B (AurkB (show AURKB Proteins)) are localized to stress granules in human astrocytoma cells
Kaplan-Meier analysis revealed that lower levels of Ect2 mRNA predicted higher overall survivals and biochemical recurrence (BCR (show BCR Proteins))-free survivals in all patients or non-metastatic patients.
Our results suggest that ECT2 plays an important role during gastric cancer progression
Colorectal cancer patients with high expression levels of ECT2 had shorter overall survival.
ECT2 can crosstalk with RACGAP1 (show RACGAP1 Proteins) to catalyse the GTP (show AK3 Proteins) exchange involved in Rho signalling to further regulate tumour initiation and metastasis.
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.
epithelial cell transforming sequence 2 oncogene
, protein ECT2-like
, epithelial cell-transforming sequence 2 oncogene
, protein ECT2
, epithelial cell transforming sequence 2 oncogene protein
, ect2 oncogene