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Loss of ECT2 expression is associated with myocardial Polyploidization Creating a Barrier to Heart Regeneration.
These results suggest that Ect2 plays roles in multiple aspects of DNA damage response.
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Ect2 may play a role in neuronal differentiation and brain development in vivo.
results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary
indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes
ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation
Elevated NEK2, DLGAP5 and ECT2 expression was negatively correlated with both overall survival (OS) and relapse-free survival (RFS).
High ECT2 expression was correlated with tumor metastasis and poor overall survival of osteosarcoma patients.
The expression of ECT2 is related to the survival of patients with breast cancer, and Its high expression is significantly associated with unfavourable survival rates.
These results identified p53 as a novel up-stream signaling molecule of ECT2 in Gastric cancer cells.
High PDC2 expression is associated with pancreatic adenocarcinoma.
While the association of ECT2 with the plasma membrane is essential for cytokinesis, our data suggest that ECT2 recruitment to the spindle midzone is insufficient to account for equatorial furrowing and may act redundantly with yet-uncharacterized signals.
Among 518 genes co-expressed with ECT2 in LUAD and 386 genes co-expressed with ECT2 in LUSC, there were only 98 genes in the overlapping cluster
E6AP suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 and Rho GTPase activity.
Ect2 regulates rRNA synthesis through a PKCiota-Ect2-Rac1-NPM signaling axis that is required for lung tumorigenesis.
Data suggest that the expression of epithelial cell transforming sequence 2 oncogene (ECT2) can serve as an alternative measurement that can compensate for the inadequacy of the current carcinoembryonic antigen (CEA) test in the diagnosis and monitoring of colorectal cancer patients.
Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma cells
Kaplan-Meier analysis revealed that lower levels of Ect2 mRNA predicted higher overall survivals and biochemical recurrence (BCR)-free survivals in all patients or non-metastatic patients.
Our results suggest that ECT2 plays an important role during gastric cancer progression
Colorectal cancer patients with high expression levels of ECT2 had shorter overall survival.
ECT2 can crosstalk with RACGAP1 to catalyse the GTP exchange involved in Rho signalling to further regulate tumour initiation and metastasis.
Up-regulation of ECT2 might contribute to the progression of gastric carcinogenesis and may be a useful prognostic indicator in gastric cancer.
Poly(ADP-ribosyl)ation is recognized by ECT2.
central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis.
ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas.
structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.
epithelial cell transforming sequence 2 oncogene
, protein ECT2-like
, epithelial cell-transforming sequence 2 oncogene
, protein ECT2
, epithelial cell transforming sequence 2 oncogene protein
, ect2 oncogene