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Human Polyclonal HDAC1 Primary Antibody for ChIP, ICC - ABIN4316728
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 12 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for IHC, IHC (fro) - ABIN4316727
Wilting, Yanover, Heideman, Jacobs, Horner, van der Torre, DePinho, Dannenberg: Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. in The EMBO journal 2010
Show all 9 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for WB - ABIN1881405
Yang, Zhou, Wu, Xie, Zhang, Zheng: Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. in Clinical chemistry and laboratory medicine : CCLM / FESCC 2010
Show all 5 Pubmed References
Human Monoclonal HDAC1 Primary Antibody for ChIP, ICC - ABIN2668767
Lagger, OCarroll, Rembold, Khier, Tischler, Weitzer, Schuettengruber, Hauser, Brunmeir, Jenuwein, Seiser: Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. in The EMBO journal 2002
Show all 4 Pubmed References
Human Monoclonal HDAC1 Primary Antibody for WB - ABIN1882195
Furukawa, Kawakami, Sudo, Inazawa, Matsumine, Akiyama, Nakamura: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. in Cytogenetics and cell genetics 1996
Show all 5 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for IP, IHC - ABIN223295
Cao, Li, Zhu, Shen, Han, Zhang, Yu, Wang, Wu, Chen, Sun, Tang, Zhao, Qiao, Hou, Mao: The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. in The Journal of biological chemistry 2013
Show all 2 Pubmed References
Human Monoclonal HDAC1 Primary Antibody for IF, IHC (p) - ABIN516392
Nakayama, Mikoshiba, Akagawa: The cell- and tissue-specific transcription mechanism of the TATA-less syntaxin 1A gene. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016
Human Polyclonal HDAC1 Primary Antibody for ICC, IF - ABIN4316731
Bártová, Šustáčková, Stixová, Kozubek, Legartová, Foltánková: Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. in PLoS ONE 2011
Human Polyclonal HDAC1 Primary Antibody for ELISA, ICC - ABIN4316730
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
Human Polyclonal HDAC1 Primary Antibody for ChIP, ELISA - ABIN4316734
Miyatani, Kurita, Mikami, Kashihara, Higashijima, Yoshikawa, Nishioka, Sato, Iwata, Shimada: Malignant potential of Barrett's esophagus: special reference to HDAC-1 and MTA-1 expression. in Hepato-gastroenterology 2011
HDAC1 SUMOylation functions as an endogenous defense mechanism protecting against Abeta (show APP Antibodies)-toxicity. Stimuli such as BDNF (show BDNF Antibodies), IGF-1 (show IGF1 Antibodies) and CRF (show CRH Antibodies) that increase the level of HDAC1 SUMOylation without altering the HDAC1 expression level
Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.
Co-regulation of H3K9ac by HDAC1 and HDAC3 (show HDAC3 Antibodies) is important to both embryonic brain development and neuro-differentiation.
Treatment of the haplotype Npr1 (show NPR1 Antibodies)(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (show NFKB1 Antibodies) (p65 (show NFkBP65 Antibodies)), and STAT1 (show STAT1 Antibodies).
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Antibodies) and HDAC1-HDAC2 has been described.
Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli.
In line with the acetyltransferase activity of p300 (show NOTCH1 Antibodies), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Antibodies) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Antibodies) to its gene
provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Antibodies)-associated protein 3 (show HSPB3 Antibodies) and establish the essential role of striatal Hdac1, Hdac2 (show HDAC2 Antibodies) and MeCP2 for suppression of repetitive behaviors
Taken together, Fam60a is an essential core subunit of a variant Sin3a (show SIN3A Antibodies)-Hdac (show HDAC3 Antibodies) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors
These results reveal the presence of an MSI1 (show MSI1 Antibodies)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.
HDC1 is a ubiquitously expressed nuclear protein (show UBN1 Antibodies) that interacts with at least two deacetylases (HDA6 (show HDAC6 Antibodies) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.
findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19
HDA6 (show HDAC6 Antibodies) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]
Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
These results suggest that acetylation of specific histone Lys (show LYZ Antibodies) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
These results suggest that during germination in Arabidopsis, HDA6 (show HDAC6 Antibodies) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
aken together, these results reveal that inactivation of Rpd3 independently regulates JNK (show MAPK8 Antibodies) and Yki (show YAP1 Antibodies) activities and that both Hippo and JNK (show MAPK8 Antibodies) signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (show MSN Antibodies) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
This study tested the longevity effects of RPD3 on multiple nutrient levels.
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Study shows that Fru (show ZBTB22 Antibodies) forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (show CBX5 Antibodies)), which demasculinizes them.
The dose of Rpd3 is critical for normal long-term memory.
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.
Our study suggests a specific function for the general chromatin remodeling factor (show ASH1L Antibodies) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
The authors found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting in hypo-acetylation of lysine 18 of histone H3 (show HIST3H3 Antibodies) at pro-inflammatory cytokine loci. Specifically, 2-aminoacetophenone induced reprogramming of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in vitro.
Results suggest that RBM45 (show RBM45 Antibodies) serves as a negative regulator to prevent FUS (show FUS Antibodies)-mediated excessive recruitment of HDAC1 to the sites of DNA damage.
Histone deacetylases (HDACs) inhibitor MGCD0103 (MGCD) induces apoptosis by up-regulating p53 (show TP53 Antibodies) in CNE2 nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) cells.
Our findings suggest that up-regulation of UVRAG (show UVRAG Antibodies) by HDAC1 inhibition potentiates DNA-damage-mediated cell death in colorectal cancer cells
The findings suggest that OGT (show OGT Antibodies) promotes the O-GlcNAc (show OGT Antibodies) modification of HDAC1 in the development of progression hepatocellular carcinoma.
HDAC1 promoted migration and invasion of gallbladder tumor cells by binding with TCF12 (show TCF12 Antibodies) to promote epithelial mesenchymal transformation.
HDAC1 depletion-induced p53 (show TP53 Antibodies) expression alters cardiac-derived mesenchymal stromal cell fate decisions.
These results are the first evidence that the inhibition of HDAC1 by (S)-2 downregulates CIP2A (show KIAA1524 Antibodies) transcription
data showed that HDAC1 can trigger the proliferation and migration of breast cancer cells via activation of Snail (show SNAI1 Antibodies)/IL-8 (show IL8 Antibodies) signals
Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (show DNMT3A Antibodies) are reported.
The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.
results indicate that HDAC1 plays an important role in otic vesicle formation.
HDAC (show HDAC3 Antibodies) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.
This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
Hdac1 is required for expression of erm (show ETV5 Antibodies) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (show NOTCH1 Antibodies) signalling activity
HDAC1 is required for pancreatic epithelial proliferation in development and cancer.
Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.
Findings suggest that Mta3 (show MTA1 Antibodies)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.
hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.
in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
, histone deacetylase 1
, histone deacetylase 1-B
, Rpd3 histone deacetylase
, histone Deacetylase-1
, histone deacetylase
, histone deacetylase 1 (HDAC1)
, reduced potassium dependency 3
, suppressor of variegation 326
, reduced potassium dependency, yeast homolog-like 1
, histone deacetylase 1 b