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Chicken Polyclonal HDAC2 Primary Antibody for ICC, WB - ABIN223296
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
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Human Monoclonal HDAC2 Primary Antibody for ICC, IF - ABIN2668730
Nayak, Glöckner-Pagel, Vaeth, Schumann, Buttmann, Bopp, Schmitt, Serfling, Berberich-Siebelt: Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. in The Journal of biological chemistry 2009
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Human Monoclonal HDAC2 Primary Antibody for WB - ABIN1882048
Yang, Inouye, Zeng, Bearss, Seto: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Polyclonal HDAC2 Primary Antibody for IF (p), IHC (p) - ABIN801348
Jou, Chen, Liu, Way, Lai, Hua, Wang, Huang, Kao, Lin: Quantitative phosphoproteomic analysis reveals ?-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation. in Proteomics 2015
Human Polyclonal HDAC2 Primary Antibody for WB - ABIN966259
Betz, Gray, Ekström, Larsson, Ekström: Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. in Genomics 1998
Human Polyclonal HDAC2 Primary Antibody for IP - ABIN151654
Huang, Kesselman, Kizub, Guerrero-Preston, Ratovitski: Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. in Cell cycle (Georgetown, Tex.) 2013
Human Polyclonal HDAC2 Primary Antibody for ICC, IF - ABIN4317577
Baek, Park, Rhim, Park, Kim, Kim, Nam: Immunohistochemical Characterization of Histone Deacetylase as a Potential Prognostic Marker and Therapeutic Target in Endometrial Stromal Sarcoma. in Anticancer research 2016
Human Polyclonal HDAC2 Primary Antibody for ELISA, ICC - ABIN4317573
de Ruijter, van Gennip, Caron, Kemp, van Kuilenburg: Histone deacetylases (HDACs): characterization of the classical HDAC family. in The Biochemical journal 2003
Human Polyclonal HDAC2 Primary Antibody for ICC, IF - ABIN4317578
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
Mouse (Murine) Monoclonal HDAC2 Primary Antibody for ChIP, ICC - ABIN1042602
Zupkovitz, Tischler, Posch, Sadzak, Ramsauer, Egger, Grausenburger, Schweifer, Chiocca, Decker, Seiser: Negative and positive regulation of gene expression by mouse histone deacetylase 1. in Molecular and cellular biology 2006
Taken together, these data clearly show that FKBP3 (show FKBP3 Antibodies)/Sp1 (show PSG1 Antibodies)/HDAC2/p27 (show PAK2 Antibodies) control cell proliferation during non-small cell lung cancer development.
HDAC1 (show HDAC1 Antibodies) and HDAC2 suppress the expression of PPP2R3A/PR130 (show PPP2R3A Antibodies), a regulatory subunit of the trimeric serine/threonine phosphatase 2 (PP2A (show PPP2R4 Antibodies)).
Knockdown of HDAC2 completely mimicked the effects of 1,25(OH)2D3 on PTEN gene expression.
Muscle biopsies of chronic obstructive pulmonary disease significantly correlated with HDAC2 decrease compared to controls.
Nuclear HDAC2 immunopositivity was significantly higher in actinic cheilitis (AC) when compared with lip squamous cell carcinoma (LSCC). HDAC1 (show HDAC1 Antibodies) and HAT1 (show HAT1 Antibodies) nuclear immunostaining were higher in AC, with no statistical significance. When comparing data with our previous study, we found a positive correlation between HDAC1 (show HDAC1 Antibodies) X DNMT1 (show DNMT1 Antibodies)/DNMT3b (show DNMT3B Antibodies), HDAC2 X DNMT3b (show DNMT3B Antibodies), and HAT1 (show HAT1 Antibodies) X DNMT1 (show DNMT1 Antibodies)/DNMT3b (show DNMT3B Antibodies) for certain studied groups.
With tissue microarrays of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients, we determined the prognostic values of the core genes in the network and found that RAD21 (show RAD21 Antibodies), CDK1 (show CDK1 Antibodies), and HDAC2 expression levels were negatively associated with overall survival for HCC (show FAM126A Antibodies) patients.
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1 (show CHEK1 Antibodies), and RAD51 (show RAD51 Antibodies) expression in acute myeloid leukemia (show BCL11A Antibodies) cells.
Combined treatment with the histone deacetylase (show HDAC1 Antibodies) inhibitors (HDACi) suberoylanilide hydroxamic acid plus 5-fluorouracil (5-FU) and oxaliplatin (Oxa) reduced the level of HDAC2 expression in HT-29 cells.
miR (show MLXIP Antibodies)-223 controls the expression of CX3CL1 (show CX3CL1 Antibodies) by targeting HDAC2 in chronic obstructive pulmonary disease patients and mouse models of the disease.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
The E26 transformation-specific transcription factor, ETV4 (show ETV4 Antibodies), which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase (show HDAC1 Antibodies) HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.
In the delayed phase after stroke, administration of HDAC2 inhibitors promoted functional recovery via epigenetically increased neuroplasticity-related genes expression leading to circuit reorganization in the peri (show POSTN Antibodies)-infarct area.
Hdac2 silencing in pregnant mice elevated placental P-gp (show ABCB4 Antibodies) expression and decreased digoxin transplacental transfer rate.
the epigenetic regulators HDAC1 (show HDAC1 Antibodies) and HDAC2 control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles.
these findings suggested that HDAC2 may be an important negative regulator involved in chronic stressinduced cognitive impairment.
Study demonstrated that in the mouse liver, HDAC2 is primarily expressed in hepatocytes. CD36 (show CD36 Antibodies) deletion inhibited nuclear expression of HDAC2 in hepatocytes but had no impact on the expression of HDAC2 in macrophages.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
The findings suggest that miR (show MLXIP Antibodies)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 (show HIST3H3 Antibodies) acetylation.
Treatment of the haplotype Npr1 (show NPR1 Antibodies)(+/-) mice with histone deacetylase (show HDAC1 Antibodies) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Antibodies)/2, NF-kappaB (show NFKB1 Antibodies) (p65 (show NFkBP65 Antibodies)), and STAT1 (show STAT1 Antibodies).
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
YY1-associated factor 1
, transcriptional regulator homolog RPD3
, YY1 transcription factor-binding protein
, histone deacetylase-2