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Human Polyclonal YWHAE Primary Antibody for ICC, IF - ABIN4276669
Lee, Ou, Mariño-Enriquez, Zhu, Mayeda, Wang, Guo, Brunner, Amant, French, West, McAlpine, Gilks, Yaffe, Prentice, McPherson, Jones, Marra, Shah, van de Rijn, Huntsman, Dal Cin, Debiec-Rychter, Nucci et al.: 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. ... in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 2 Pubmed References
Chicken Polyclonal YWHAE Primary Antibody for IHC (p), ELISA - ABIN2477183
Gorenstein: A hypothesis concerning the role of endogenous colchicine-like factors in the etiology of Alzheimer's disease. in Medical hypotheses 1987
Show all 4 Pubmed References
Dog (Canine) Polyclonal YWHAE Primary Antibody for WB - ABIN2792142
Tak, Jang, Kim, Park, Suk, Yoon, Ahn, Lee, Joe: 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization. in Cellular signalling 2007
Chicken Polyclonal YWHAE Primary Antibody for IHC (p), ELISA - ABIN2477182
Aitken: 14-3-3 proteins: a historic overview. in Seminars in cancer biology 2006
Human Polyclonal YWHAE Primary Antibody for EIA, IF - ABIN272265
Nagappan, Park, Park, Hong, Yumnam, Lee, Kim, Kim, Lee, Lee, Cho, Lee, Won, Cho, Kim: Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice. in Chemico-biological interactions 2013
Human Polyclonal YWHAE Primary Antibody for ICC, IF - ABIN442656
Dowling, Moran, McAuley, Meleady, Henry, Clynes, McMenamin, Leonard, Monks, Wynne, Ormond, Larkin: Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome. in Oncology letters 2016
14-3-3epsilon has a critical role in cellular metabolism involving either molecular crosstalk with the EcR or direct interaction with metabolic proteins
The Khc73 stalk/14-3-3 (show YWHAZ Antibodies)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11 (show RAB11A Antibodies)-positive vesicle function, which in turn enables antimicrobial peptide (show CAMP Antibodies) secretion during an innate immune response.
Hpo (show GFER Antibodies) signaling inhibited Yki (show YAP1 Antibodies) nuclear localization and activity by phosphorylating Yki (show YAP1 Antibodies) and both isoforms of 14-3-3 (show YWHAZ Antibodies), 14-3-3varepsilon and 14-3-3zeta (show YWHAZ Antibodies), regulate Yki (show YAP1 Antibodies) activity through modulating its subcellular localization.
Drosophila 14-3-3/PAR-5 (show YWHAZ Antibodies) is an essential mediator of PAR-1 (show F2R Antibodies) function in axis formation.
PAR-1 (show F2R Antibodies) phosphorylates Bazooka/PAR-3 (show PARD3 Antibodies) on two conserved serines to generate 14-3-3 (show YWHAZ Antibodies) binding sites. This inhibits formation of the Bazooka (show PARD3 Antibodies)/PAR-6 (show PARD6A Antibodies)/aPKC complex by blocking Bazooka (show PARD3 Antibodies) oligomerization and binding to aPKC.
Serves as a central modulator of forkhead transcription factor FoxO (show FOXO Antibodies) activity in the regulation of growth, cell death and longevity in vivo.
The expression of epsilon isoforms of 14-3-3 protein was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
results support YWHAE being a risk gene for Major Depressive Disorder in the Han Chinese population.
YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B (show CDC25B Antibodies) and MYC (show MYC Antibodies) in gastric cancer cells.
we report recurrent BCOR (show BCOR Antibodies) exon 16 internal tandem duplications and YWHAE-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
For metastatic YWHAE-rearranged HG-ESS, prolonged disease control following diagnosis was seen, with notable responses to anthracycline-based therapy. This emphasizes the need for appropriate molecular testing of uterine mesenchymal malignancies.
phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (show YWHAZ Antibodies) interacts with the kinase domain of ASK1 (show MAP3K5 Antibodies) in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.
The 14-3-3 (show YWHAQ Antibodies) family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon, theta and zeta isoforms could be useful indicators of disease severity.
Studies show that patients with clear cell sarcoma of the kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young, had low tumor volumes, and did not present with stage I disease which fail to identify an explicit clinical phenotype.
Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I (show DDX58 Antibodies)) to the adaptor MAVS (show MAVS Antibodies) protein and thereby blocked antiviral signaling.
Report mutually exclusive BCOR (show BCOR Antibodies) internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney.
CEP131 (show AZI1 Antibodies) is the key regulatory target of MK2 (show KCNA2 Antibodies) and 14-3-3 (show YWHAQ Antibodies) in centriolar satellite remodeling.
Authors used 14-3-3epsilon (Ywhae) flox mice and found that 14-3-3epsilon deficiency results in an increase in neurite formation.
The complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors in mice.
The data obtained from the 14-3-3epsilon/14-3-3zeta (show YWHAZ Antibodies)/Wnt1 (show WNT1 Antibodies)-Cre mice strongly indicate the importance of 14-3-3 (show YWHAQ Antibodies) proteins in the development of melanocyte lineages.
14-3-3epsilon might directly bind to CD13 (show ANPEP Antibodies), which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.
Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B (show CDC25B Antibodies) in cytoplasm. Its binding to CDC25B (show CDC25B Antibodies)-S321 phosphorylated by PKA induces mitotic arrest.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
14-3-3epsilon deletion did not appear to induce compensation by other 14-3-3 (show YWHAQ Antibodies) isoforms but led to ventricular noncompaction, resulting from a selective reduction in compact myocardium thickness.
14-3-3epsilon haploinsufficiency decreased the incorporation of expanded ATXN1 (show ATXN1 Antibodies) into its large toxic complexes in the cerebellum but not in the brainstem, and the distribution of ATXN1 (show ATXN1 Antibodies)'s small and large native complexes differed significantly between two regions
14-3-3 epsilon belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation
The finding of this study suggested that dysfunction of the TH neuronal network caused by the deficit of 14-3-3 epsilon may have been involved in the pathophysiology of schizophrenia and correlated with a dysfunction in the DISC1 (show DISC1 Antibodies) complex.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
, suppressor of Ras85D 3-9
, 14-3-3 epsilon
, 14-3-3 epsilon protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide
, 14-3-3 protein epsilon
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
, mitochondrial import stimulation factor L subunit
, protein kinase C inhibitor protein-1
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
, MSF L
, mitochondrial import stimulation factor (MSF) L subunit
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide
, 14-3-3 protein