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Human Polyclonal YWHAE Primary Antibody for ICC, IF - ABIN4276669
Lee, Ou, Mariño-Enriquez, Zhu, Mayeda, Wang, Guo, Brunner, Amant, French, West, McAlpine, Gilks, Yaffe, Prentice, McPherson, Jones, Marra, Shah, van de Rijn, Huntsman, Dal Cin, Debiec-Rychter, Nucci et al.: 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. ... in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 2 Pubmed References
Human Polyclonal YWHAE Primary Antibody for EIA, IF - ABIN272265
Nagappan, Park, Park, Hong, Yumnam, Lee, Kim, Kim, Lee, Lee, Cho, Lee, Won, Cho, Kim: Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice. in Chemico-biological interactions 2013
Dog (Canine) Polyclonal YWHAE Primary Antibody for WB - ABIN2792142
Tak, Jang, Kim, Park, Suk, Yoon, Ahn, Lee, Joe: 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization. in Cellular signalling 2007
Human Polyclonal YWHAE Primary Antibody for ICC, IF - ABIN442656
Dowling, Moran, McAuley, Meleady, Henry, Clynes, McMenamin, Leonard, Monks, Wynne, Ormond, Larkin: Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome. in Oncology letters 2016
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb.
14-3-3epsilon has a critical role in cellular metabolism involving either molecular crosstalk with the EcR or direct interaction with metabolic proteins
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11-positive vesicle function, which in turn enables antimicrobial peptide secretion during an innate immune response.
Hpo signaling inhibited Yki nuclear localization and activity by phosphorylating Yki and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki activity through modulating its subcellular localization.
Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation.
PAR-1 phosphorylates Bazooka/PAR-3 on two conserved serines to generate 14-3-3 binding sites. This inhibits formation of the Bazooka/PAR-6/aPKC complex by blocking Bazooka oligomerization and binding to aPKC.
Serves as a central modulator of forkhead transcription factor FoxO activity in the regulation of growth, cell death and longevity in vivo.
The expression of epsilon isoforms of 14-3-3 protein was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
results support YWHAE being a risk gene for Major Depressive Disorder in the Han Chinese population.
YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells.
we report recurrent BCOR exon 16 internal tandem duplications and YWHAE-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
For metastatic YWHAE-rearranged HG-ESS, prolonged disease control following diagnosis was seen, with notable responses to anthracycline-based therapy. This emphasizes the need for appropriate molecular testing of uterine mesenchymal malignancies.
phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.
The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon, theta and zeta isoforms could be useful indicators of disease severity.
Studies show that patients with clear cell sarcoma of the kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young, had low tumor volumes, and did not present with stage I disease which fail to identify an explicit clinical phenotype.
Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I) to the adaptor MAVS protein and thereby blocked antiviral signaling.
Report mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney.
CEP131 is the key regulatory target of MK2 and 14-3-3 in centriolar satellite remodeling.
14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.
DAPK2-induced apoptosis is negatively regulated by Akt and 14-3-3 proteins.
These data demonstrate a novel role for HDAC6 in controlling 14-3-3zeta binding activity.
YWHAE-FAM22 rearrangement is associated with endometrial stromal sarcomas.
Results suggest a specific role for YWHAE single nucleotide polymorphisms in the pathophysiology of schizophrenia.
Cleft lip/palate has been found associated with 17p13.3 duplication involving a single candidate gene (YWHAE) in a father and his son.
Data show that two isoforms of the 14-3-3 family, 14-3-3epsilon and 14-3-3 gamma, can stabilize Cdt2 independent of each other when overexpressed.
These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern in patients with schizophrenia.
data indicate that 14-3-3 is required for Bim expression and that it has an anti-cancer effect under pERK1/2 inhibition in 143B cells
for endometrial sarcoma cases with high-grade morphology we recommend to test for YWHAE rearrangements by FISH break-apart
Rod photoreceptors are enriched in YWHAE (14-3-3 epsilon). Immunohistochemistry revealed that 14-3-3 epsilon and 14-3-3 zeta exhibit unique distributions in photoreceptors with 14-3-3 epsilon restricted to the inner segment and 14-3-3 zeta localized to the outer segment.
Authors used 14-3-3epsilon (Ywhae) flox mice and found that 14-3-3epsilon deficiency results in an increase in neurite formation.
The complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors in mice.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.
Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B in cytoplasm. Its binding to CDC25B-S321 phosphorylated by PKA induces mitotic arrest.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
14-3-3epsilon deletion did not appear to induce compensation by other 14-3-3 isoforms but led to ventricular noncompaction, resulting from a selective reduction in compact myocardium thickness.
14-3-3epsilon haploinsufficiency decreased the incorporation of expanded ATXN1 into its large toxic complexes in the cerebellum but not in the brainstem, and the distribution of ATXN1's small and large native complexes differed significantly between two regions
14-3-3 epsilon belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation
The finding of this study suggested that dysfunction of the TH neuronal network caused by the deficit of 14-3-3 epsilon may have been involved in the pathophysiology of schizophrenia and correlated with a dysfunction in the DISC1 complex.
14-3-3epsilon interacts directly with PDX-1 to regulate its cellular distribution in pancreatic beta cells.
overexpression of 14-3-3epsilon led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins.
The appearance of 14-3-3 proteins in the cerebrospinal fluid is characteristic of some neurodegenerative conditions
14-3-3epsilon is important for neuronal migration by binding to NUDEL and provide a molecular explanation for the differences in severity of human neuronal migration defects with 17p13.3 deletions
14-3-3 adapter proteins may have a role in regulating CD81 signaling, possibly dependent on cellular redox
HSF1 associates with ERK1 and 14-3-3epsilon during heat shock to modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions
UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase.
aldosterone-induced 14-3-3 isoforms, beta and epsilon, interact with phospho-Nedd4-2 as an obligatory heterodimer, blocking its interaction with ENaC and thereby increasing apical ENaC density and sodium transport.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
, suppressor of Ras85D 3-9
, 14-3-3 epsilon
, 14-3-3 epsilon protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide
, 14-3-3 protein epsilon
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
, mitochondrial import stimulation factor L subunit
, protein kinase C inhibitor protein-1
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
, MSF L
, mitochondrial import stimulation factor (MSF) L subunit
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide
, 14-3-3 protein