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SPG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER proteins, and functions in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
findings indicate that protrudin interacts with spastin (show SPAST Proteins) and induces axon formation through its N-terminal domain. Moreover, protrudin and spastin (show SPAST Proteins) may work together to play an indispensable role in motor axon outg
Protrudin-KIF5 com (show KIF5A Proteins)plex contributes to the vesicular trans (show KIF5A Proteins)port in neurons.
protrudin regulates Rab11 (show RAB11A Proteins)-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation [protrudin]
The role of ZFYVE27/protrudin in hereditary spastic paraplegia is reported.
VAP-A (show VAPA Proteins) is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth.
We found that Zfyve27, which encodes protrudin, identified a subpopulation of papillary label-retaining cells (pLRCs). With Zfyve27-CreERT2 transgenic and reporter mice we generated bitransgenic animals and performed cell-lineage analysis. Post tamoxifen, Zfyve27-CreERT2 marked cells preferentially located in the upper part of the papilla.
Identification and characterization of protrudin-L, neuron-specific isoform of protrudin that promotes axonal elongation and contributes to the establishment of neuronal polarity.
Phosphoinositides differentially regulate protrudin localization through the FYVE domain [protrudin]
protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.
Protrudin and KIF5 (show KIF5A Proteins) interact in mouse brain.Protrudin-KIF5 (show KIF5A Proteins) complex contributes to the vesicular transport in neurons.
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.
zinc finger, FYVE domain containing 27
, zinc finger FYVE domain-containing protein 27
, Zinc finger FYVE domain-containing protein 27