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Cow (Bovine) Growth Hormone 1 Protein expressed in - ABIN621622
Wang, Ji, Wang, Chen, Wang, Loor: The preliminary study on the effects of growth hormone and insulin-like growth factor-I on κ-casein synthesis in bovine mammary epithelial cells in vitro. in Journal of animal physiology and animal nutrition 2016
Human Growth Hormone 1 Protein expressed in Escherichia coli (E. coli) - ABIN803848
Mano-Otagiri, Nemoto, Sekino, Yamauchi, Shuto, Sugihara, Oikawa, Shibasaki et al.: Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ... in Endocrinology 2006
GH1 and GHRHR screening revealed eleven variations in 24 (21%) patients with isolated growth hormone deficiency of which, four were novel deleterious, one novel non-pathogenic and six reported changes.
The results suggest that GH regulates energy metabolism directly in myocytes and that UCP2 (show UCP2 Proteins) participates in the signal transduction pathway that functions downstream of the GHR (show GHR Proteins)/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins).
These results implicate TIMP3 (show TIMP3 Proteins) as a modulator of cell surface GHR (show GHR Proteins) abundance and the ability of GH to promote cellular signaling.
Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 (show NF1 Proteins) patients, similarly to central precocious puberty
Thus, GHRH (show GHRH Proteins) analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of GHRH (show GHRH Proteins) receptors levels.
The intrinsic amyloidogenicity of growth hormone, in the presence of contaminating prion protein (show PRNP Proteins) (and perhaps prolactin (show PRL Proteins) as well) and amyloid-beta contained in some cadavers' pituitaries, may have led to the observed co-occurring of Creutzfeldt-Jakob disease and Alzheimer's disease.
To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.
Data show that the recombinant protein produced by the plasmid-free E coli strain was purified and characterized to be human growth hormone (hGH).
Our results suggest that the known protective effect of GH signaling deficiency on neoplastic tissue growth is mediated, at least partially, by regulating p53 (show TP53 Proteins) expression
Gene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with Growth hormone deficiency susceptibility.
These results indicate that up-regulation of GH in the lungs of DJ-1 (show PARK7 Proteins) KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
Confirmation of the impairment of GH-IGF-1 (show IGF1 Proteins) release in hyperphagic MC4R (show MC4R Proteins) KO mice suggests a role for insulin (show INS Proteins) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (show IGF1 Proteins) levels
When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 (show IGF1 Proteins) receptor were broadly protected from cell damage, neuroinflammation and cerebral edema.
Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys (show DNAJC5 Proteins) in the thiol reactant.
Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
alter miR (show MLXIP Proteins)-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC (show FUT1 Proteins) migration
Moderate elevations in circulating GH and IGF-I (show IGF1 Proteins) can directly increase basal insulin (show INS Proteins) secretion without impacting beta-cell mass, independent of changes in whole body insulin (show INS Proteins) sensitivity and hyperlipidemia.
Acylated ghrelin (show GHRL Proteins) is not required for the surge in pituitary growth hormone observed in pregnant mice.
STAT5 (show STAT5A Proteins) signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.
bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 (show FGF21 Proteins) levels were significantly elevated in bGH mice. Expression of Fgf21 (show FGF21 Proteins), Fgfr1 (show FGFR1 Proteins), and Klb (show KLB Proteins) mRNA in white AT and liver were downregulated or unchanged in bGH mice.
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN (show MSTN Proteins)/DraI.
An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.
The association of IGF1 (show IGF1 Proteins), GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.
The total frequencies for the combined genotypes for the bGH and RORC (show RORC Proteins) genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
Whereas only moderate structural changes were observed with up-regulation of GH/IGF-I (show IGF1 Proteins) axis, disruption of the GH receptor (show GHR Proteins) had pronounced effects upon tendon ultra-structure.
this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL (show PRL Proteins) gene transcription in dairy cow anterior pituitary cells
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 (show POU1F1 Proteins) gene (AB) was desirable
one GH1 SNP, GH33, was significantly associated with milk protein (show CSN2 Proteins) yield in the second lactation. Several GH1 SNPs were significantly associated with fertility.
GH and IGF-I (show IGF1 Proteins) genotypes had no substantial effect on productive parameters, though IGF-I (show IGF1 Proteins) genotype affected calving-first service interval in primiparous cows. However, the genotypes do alter the endocrine/metabolic profiles of the transition dairy cow.
Data indicate that the dual effects of cortistatin (show CORT Proteins) on growth hormone release parallel those of somatostatin (show SST Proteins) and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.
ghrelin increased growth hormone secretion but not growth hormone synthesis by ovarian follicles
Plasma levels of growth hormone (as well as glucose, insulin (show INS Proteins), and leptin (show LEP Proteins)) are highly correlated with the duration of winter anovulatory phase.
Expression of PRL (show PRL Proteins) and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL (show PRL Proteins) and GH for other species.
Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR (show GHR Proteins) excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.
that concomitant overexpression of GH and GHR (show GHR Proteins) resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1 (show STAT5B Proteins).
Effects of somatotrophic axis (GH/GHR (show GHR Proteins)) double transgenesis on structural and molecular aspects of the zebrafish immune system
The zebrafish gh1 mutant, vizzini, exhibits decreased somatic growth, increased adipose tissue accumulation, and disrupted adipose plasticity after nutrient deprivation.
tbx5 (show TBX5 Proteins) knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis
Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1 (show IGF1 Proteins)) responses in both Atlantic salmon and rainbow trout.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
pituitary growth hormone
, growth hormone 12
, growth hormone
, growth hormone 1
, neural retina growth hormone
, gnRH receptor
, gonadotropin-releasing hormone receptor
, chorionic somatommamotropin hormone 4
, Pituitary growth hormone
, growth hormone I
, Growth hormone
, growth hormone type a long isoform
, growth hormone type a short isoform
, growth hormone protein
, Growth hormone 1
, growth hormone B3
, growth hormone type 1