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anti-Mouse (Murine) IL1B Antibodies:
anti-Rat (Rattus) IL1B Antibodies:
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Human Monoclonal IL1B Primary Antibody for CyTOF, FACS - ABIN4899224
Yates, Burgess, Kocsis-Angle, Antal, Dority, Embury, Piotrkowski, Brunden: Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. in Journal of neurochemistry 2000
Show all 15 Pubmed References
Human Monoclonal IL1B Primary Antibody for CyTOF, FACS - ABIN4899223
Oliver, Lovric, Yu, Christou, Aiken, Cooper, Walsh: Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue. in PLoS ONE 2015
Show all 15 Pubmed References
Bacteria Polyclonal IL1B Primary Antibody for ELISA, EM - ABIN269770
Petrovski, Ayna, Majai, Hodrea, Benko, Mádi, Fésüs: Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages. in Autophagy 2011
Show all 11 Pubmed References
Dog (Canine) Polyclonal IL1B Primary Antibody for IF (p), IHC (p) - ABIN728503
Zhong, Shu, Wang, Luo, Zhong, Ran, Zheng, Yin, Ling: Enhanced homing of mesenchymal stem cells to the ischemic myocardium by ultrasound-targeted microbubble destruction. in Ultrasonics 2011
Show all 11 Pubmed References
Dog (Canine) Polyclonal IL1B Primary Antibody for IHC, ELISA - ABIN1582289
Choi, Lim, Hwang, Lee, Cho, Kim: Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol. in Free radical research 2010
Show all 6 Pubmed References
Mouse (Murine) Polyclonal IL1B Primary Antibody for Neut, WB - ABIN223538
Scott, Ma, Viriyakosol, Terkeltaub, Liu-Bryan: Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 6 Pubmed References
Human Polyclonal IL1B Primary Antibody for IHC (p), IHC - ABIN446969
Omran, Peng, Zhang, Xiang, Xue, Gan, Kong, Yin: Interleukin-1β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy. in Epilepsia 2012
Show all 5 Pubmed References
Mouse (Murine) Monoclonal IL1B Primary Antibody for IP, Neut - ABIN1176987
Fei, Gott, Edwards, Schuyler: Experimental hypersensitivity pneumonitis: in vitro effects of interleukin-2 and interferon-gamma. in The Journal of laboratory and clinical medicine 1995
Show all 4 Pubmed References
Mouse (Murine) Polyclonal IL1B Primary Antibody for ELISA, FACS - ABIN4324365
Triantafilou, Kar, Vakakis, Kotecha, Triantafilou: Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. in Thorax 2012
Show all 4 Pubmed References
Human Monoclonal IL1B Primary Antibody for FACS - ABIN4895764
Hakonarson, Whelan, Leiter, Kim, Chen, Campbell, Grunstein: T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta. in The Journal of allergy and clinical immunology 2002
Show all 4 Pubmed References
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (show CASP3 Antibodies) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (show MYD88 Antibodies) axis and NADPH oxidase (show NOX1 Antibodies)-mediated ROS (show ROS1 Antibodies) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Alendronate (ALN (show TTC21B Antibodies))-augmented IL-1beta production and cell death require Smad3 (show SMAD3 Antibodies) and ASC (show STS Antibodies) activation, and SIS3 and anti-ASC (show STS Antibodies) antibodies may serve as palliative agents for necrotizing inflammatory diseases caused by ALN (show TTC21B Antibodies)
urinary LRG (show LRG1 Antibodies) is produced in renal tubular epithelial cells by interleukin-1beta (IL-1beta) that is released during proteinuria-induced renal damage
These data reveal how, upon XIAP (show XIAP Antibodies) deficiency, a TLR-TNF (show TNF Antibodies)-TNFR2 (show TNFRSF1B Antibodies) axis drives cIAP1 (show BIRC2 Antibodies)-TRAF2 (show TRAF2 Antibodies) degradation to allow TLR or TNFR1 (show TNFRSF1A Antibodies) activation of RIPK3 (show RIPK3 Antibodies)-caspase-8 (show CASP8 Antibodies) and IL-1beta. This mechanism may explain why XIAP (show XIAP Antibodies)-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations.
IL-1beta exerts variable effects on long-term potentiation at different kinds of synapses, indicating that IL-1beta has synapse-specific effects on hippocampal synaptic plasticity.
we assessed the role of RIP3 (show MPRIP Antibodies) in synergy with Caspase-1 (show CASP1 Antibodies) in the induction of IL-1beta production in BMDM after either LPS (show TLR4 Antibodies)/ATP or Chlamydia muridarum stimulation. The possibility of pyroptosis and necroptosis interplays and the role of RIP3 (show MPRIP Antibodies) in IL-1beta production during Chlamydia muridarum infection in BMDM was investigated as well.
Inhibition of signaling stimulated by both TNF (show TNF Antibodies) and IL1beta synergizes with NF-kappaB (show NFKB1 Antibodies) inhibition in eliminating leukemic stem cells.
Parenchymal polymorphonuclear myeloid-derived suppressor cell (PMN (show TBCE Antibodies)-MDSC), have a positive correlation with IL1a (show IL1A Antibodies), IL8 (show IL8 Antibodies), CXCL5 (show CXCL5 Antibodies), and Mip-1a (show CCL3 Antibodies), suggesting they may attract PMN (show TBCE Antibodies)-MDSC into the tumor
Chemokine receptor 2 (CCR2 (show CCR2 Antibodies)(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (show CD3E Antibodies)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (show CCL1 Antibodies) CCL2 (show CCL2 Antibodies), a ligand for CCR2 (show CCR2 Antibodies), included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta was greater in FACS-isolated microglia than in brain-invading monocytes
hypernociception in experimental model of autoimmune encephalomyelitis may be a consequence of the increase in some cytokines in dorsal root ganglia, especially IL-1beta.
An OA model was established in mouse articular chondrocytes (MACs) treated by interleukin-1beta (IL-1beta).
This study demonstrated that IL1B expression levels are related to major depressive disorder and conjunctly mediate the effect of childhood maltreatment history on the risk of developing major depressive disorder.
GDNF has a role in lower than expected motor development, but while IL-1beta and CXCL8/IL-8 (show IL8 Antibodies) values were higher in the group with typical motor development among preterm neonates
Our findings call into question the role of IL-1beta in the diabetic pancreas as it has been proposed in previous literature. Additionally, our results regarding the localization of IL-1beta should lead to further investigation into the role of IL-1beta in the physiology of pancreatic alpha cells.
IL-1beta rs1143627 polymorphism is not related to periodontal disease susceptibility in the overall population based on the current evidence.
Our results do not show any evidence of association between COPD (show ARCN1 Antibodies) and IL-1beta -511 and +3954 gene polymorphisms in Turkish population
Our findings suggest that AhR (show AHR Antibodies)-mediated IL-1beta regulation in cerebral endothelium could induce BBB (show ALMS1 Antibodies) breakdown and contribute to the pathogenesis of a variety of neurologic disorders.
the IL1B -511 T > C polymorphism may serve as important risk factor for recurrent miscarriage while the IL6 (show IL6 Antibodies) -634C > G polymorphism may protect against the risk of recurrent miscarriage
Our data suggests that the polymorphism in genes IL-1beta, IL-1Ra (show IL1RN Antibodies) and FABP1 (show FABP1 Antibodies) included in this study are not associated with PCOS development, but can influence important biochemical and metabolic parameters in PCOS.
both RAGE (show AGER Antibodies) and mitochondrial damage primed NLRP3 (show NLRP3 Antibodies) and pro-IL-1beta activation as upstream signals of NF-kappaB (show NFKB1 Antibodies) activity, whereas mitochondrial damage was critical for the assembly of inflammasome components. These results revealed that accumulation of AGEs in NP tissue may initiate inflammation-related degeneration of the intervertebral disc via activation of the NLRP3 (show NLRP3 Antibodies) inflammasome.
Here, the authors used a set of isogenic streptococcal NAD(+)-glycohydrolase mutants and a macrophage infection model and report that streptococcal streptococcal NAD(+)-glycohydrolase inhibits the innate immune response by decreasing inflammasome-dependent interleukin 1beta (IL-1beta) release from infected macrophages.
This study showed that the presence of embryos in oviducts on days 2-3 after mating may influence the oviductal expression of the members of the IL-1beta system, determining the action of IL-1beta, which may be considered to be the earliest sign of pregnancy in pigs.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (show IL8 Antibodies) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (show IL1RN Antibodies) and IL1RAP (show IL1RAP Antibodies) and stimulates expression of PTGS1 (show PTGS1 Antibodies) and PTGS2 (show PTGS2 Antibodies) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Antibodies)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
Mycobacterium bovis infected animals have a higher frequency of IFN-gamma (show IFNG Antibodies) producing CD4 (show CD4 Antibodies)(+) T cells and elevated plasma IL-1beta levels.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (show IL1RN Antibodies) protein and IL1B and IL1R1 (show IL1RN Antibodies) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (show P2RX7 Antibodies).
Role of TGF-beta1 (show TGFB1 Antibodies) and TNF-alpha (show TNF Antibodies) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (show IL1A Antibodies) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Antibodies) bioactivity and IL-6 (show IL6 Antibodies) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8 (show IL8 Antibodies), IL-1beta and their respective receptors, CXCR1 (show CXCR1 Antibodies) and IL-1R1 in bovine theca cells, and suggest that VEGF (show VEGFA Antibodies) is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (show PGF Antibodies)(2alpha) and PGE (show LIPF Antibodies)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (show IL1A Antibodies)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Antibodies) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Antibodies) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (show TNF Antibodies) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (show IL6 Antibodies) in rabbit cornea cells.
IL-1beta and TNF-alpha (show TNF Antibodies) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (show TNF Antibodies).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 (show SLC2A5 Antibodies) and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (show TGFB1 Antibodies), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2 (show COX2 Antibodies), and TGFbeta1 (show TGFB1 Antibodies)
Increased PGE2 production led to reduction in 5-LO (show ALOX5 Antibodies) products in LPS (show IRF6 Antibodies)-treated equine whole blood via IL-1b.
Results suggested that chemokine (show CCL1 Antibodies) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (show MMP13 Antibodies) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Antibodies) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor