Browse our anti-KHDRBS1 (KHDRBS1) Antibodies

Full name:: anti-KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Antibodies (KHDRBS1)

On www.antibodies-online.com are 129 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antibodies from 20 different suppliers available. Additionally we are shipping KHDRBS1 Proteins (11) and KHDRBS1 Kits (9) and many more products for this protein. A total of 160 KHDRBS1 products are currently listed.

Synonyms:: fj90g10, KHDRBS1, P62, p68, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899

list all antibodies	Gene Name	GeneID	UniProt
	KHDRBS1	10657	Q07666
	KHDRBS1	20218	Q60749
	KHDRBS1	117268	Q91V33
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Top referenced anti-KHDRBS1 Antibodies

Human Polyclonal KHDRBS1 Primary Antibody for ICC, IF - ABIN4351941 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)
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More Antibodies against KHDRBS1 Interaction Partners

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

Results revealed that upregulation of Sam68 significantly inhibited cisplatin-induced apoptosis in oral tongue squamous cell carcinoma cells.
The PRMT2 (show PRMT2 Antibodies) interacts with SAM68 in cells and regulates its subcellular localization via the SH3 domain (show ITSN1 Antibodies) of PRMT2 (show PRMT2 Antibodies), prompting us to investigate the potential role of PRMT2 (show PRMT2 Antibodies) in BCL-X (show BCL2L1 Antibodies) alternative splicing.
Data suggest that the first 22 bp of exon 3 in BIRC5 (show BIRC5 Antibodies) contain cis (show CISH Antibodies)-acting elements that enhance the exclusion of exon 3 to generate the survivin (show BIRC5 Antibodies) DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 is a possible trans-acting factor that binds to this cis (show CISH Antibodies)-acting element and regulates exon 3 splicing. (BIRC5/survivin (show BIRC5 Antibodies) = baculoviral IAP repeat containing 5 (show BIRC5 Antibodies); Sam68 = GAP-associated tyrosine phosphoprotein p62)
our results indicated that Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-kappaB (show NFKB1 Antibodies) activation in ulcerative colitis
Sam68 possibly participated in the progresses of T-acute lymphoblastic leukemia at least partially via AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway
Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Antibodies) activation and colon tumorigenesis.
These findings define a hitherto novel mechanism of action for Sam68 in governing p53 (show TP53 Antibodies) transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities.
HNRNPL (show HNRNPL Antibodies) acts as the adaptor to combine the two substructures and form the intact Sam68 nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures.
Sam68 was overexpressed in EOC tissue in association with such cancer malignant factors of FIGO stage, histological grade, and lymph node metastasis, and also positively regulated the proliferation of EOC cells.
Taken together, these results illuminated that enterovirus 71 infections can induce stress granule formation, and Sam68, as a stress granule component, migrates alone with stress granules dependent on intact microtubule upon the viral infections.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

Sam68-haploinsufficiency significantly delayed the onset of tumors in mice lacking p53 (show TP53 Antibodies) and prolonged their survival, indicating that Sam68 accelerates the development of p53 (show TP53 Antibodies)-deficient tumors.
Sam68 deletion diminishes gamma-irradiation-triggered PAR (show AFG3L2 Antibodies) synthesis and NF-kappaB (show NFKB1 Antibodies) activation in colon epithelial cells (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs to undergo apoptosis in mice post whole-body gamma-irradiation (WBIR).
This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 (show ALDH1A3 Antibodies) expression and maintenance of high glycolytic metabolism in the developing cortex.
our results indicated that Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-kappaB (show NFKB1 Antibodies) activation in ulcerative colitis
Sam68 may function as an immune rheostat that balances the activation of NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) and c-Rel (show NFkBP65 Antibodies), as well as MAPK (show MAPK1 Antibodies), revealing a potential novel target to manipulate TLR signaling.
Sam68 plays a crucial role in DNA damage response via regulating DNA damage-initiated PAR (show AFG3L2 Antibodies) production.
Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Antibodies) activation and colon tumorigenesis.
Sam68 and T-STAR (show KHDRBS3 Antibodies) could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.
SAM68 is a physiological regulator of SMN2 (show SMN1 Antibodies) splicing in a spinal muscular atrophy mouse model.
Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

KHDRBS1 Antigen Profile

Antigen Summary

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with KHDRBS1

KH RNA binding domain containing, signal transduction associated 1 (KHDRBS1) antibody
KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a) antibody
KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1) antibody
KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1) antibody
KH RNA binding domain containing, signal transduction associated 1 (Khdrbs1) antibody
KH domain containing, RNA binding, signal transduction associated 1 S homeolog (khdrbs1.S) antibody

fj90g10 antibody
KHDRBS1 antibody
P62 antibody
p68 antibody
Sam68 antibody
wu:fa18g12 antibody
wu:fa56c01 antibody
wu:fc91b01 antibody
wu:fj90g10 antibody
zgc:113899 antibody

Protein level used designations for KHDRBS1

GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , sam68 , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68

GENE ID	SPECIES
10657	Homo sapiens
30082	Danio rerio
374071	Gallus gallus
456705	Pan troglodytes
487316	Canis lupus familiaris
538775	Bos taurus
549799	Xenopus (Silurana) tropicalis
100025483	Monodelphis domestica
20218	Mus musculus
117268	Rattus norvegicus
398660	Xenopus laevis
100725478	Cavia porcellus

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Show all anti-KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antibodies with Pubmed References

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

Antigen Summary

Alternative names and synonyms associated with KHDRBS1

Protein level used designations for KHDRBS1