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Human p65 Protein expressed in HEK-293 Cells - ABIN2730698
Srinivasan, Blackburn, Lahiri: Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. in Drug design, development and therapy 2015
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Human p65 Protein expressed in Wheat germ - ABIN1317783
Ba, Bacsi, Luo, Aguilera-Aguirre, Zeng, Radak, Brasier, Boldogh: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. in Journal of immunology (Baltimore, Md. : 1950) 2014
PU.1 supports TRAIL-induced cell death by inhibiting RelA-mediated cell survival and inducing DR5 (show TNFRSF10B Proteins) expression.
EGF (show EGF Proteins) and TNFalpha (show TNF Proteins) cooperatively promoted the motility of HCC (show FAM126A Proteins) cells mainly through NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF (show EGF Proteins) and TNFalpha (show TNF Proteins) in promoting HCC (show FAM126A Proteins), and provide potential targets for HCC (show FAM126A Proteins) prevention and treatment.
The Brd4 (show BRD4 Proteins) acetyllysine-binding protein of RelA is involved in activation of polyomavirus JC.
MUC1 (show MUC1 Proteins)-C activates the NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) pathway, promotes occupancy of the MUC1 (show MUC1 Proteins)-C/NF-kappaB (show NFKB1 Proteins) complex on the DNMT1 (show DNMT1 Proteins) promoter and drives DNMT1 (show DNMT1 Proteins) transcription
oncogenic fusions of RELA, whose protein product is the principal effector of canonical NF-kappaB (show NFKB1 Proteins) signaling. RELA fusion proteins activate signaling for tumor proliferation and malignant progression, resulting in poorer prognoses in patients with supratentorial anaplastic ependymoma.
Results showed that the C-terminus of RELA is involved both in TWIST1 (show TWIST1 Proteins) binding and IL-8 (show IL8 Proteins) promoter activation.
Isoliensinine suppresses NF-kappaB (show NFKB1 Proteins) in hepatocellular carcinoma cells through impairing PP2A (show PPP2R4 Proteins)/I2PP2A interaction and stimulating PP2A (show PPP2R4 Proteins)-dependent p65 (show GORASP1 Proteins) dephosphorylation at Ser536
Because the expression of these genes correlates with cell shape, these are likely mechanosensitive genes that regulate SMAD3 (show SMAD3 Proteins) and/or RELA activation in response to mechanical cues
NFkappaB sustains diverse cancer phenotypes via distinct classical and alternative signaling pathways, with implications for disease recurrence and therapeutic response.
data further showed that p300 (show EP300 Proteins) also regulates CCL2 (show CCL2 Proteins) expression via interaction with NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins), as depletion of p300 (show EP300 Proteins) inhibits both NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) activation and its binding to CCL2 (show CCL2 Proteins) promoter.
Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder
These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Proteins)/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB (show NFKB1 Proteins).
Zinc finger nuclease (show DCLRE1C Proteins) in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A (show CORO1A Proteins) is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB (show NFKB1 Proteins) p65 (show SYT1 Proteins) subunit (pp65 (show LCP1 Proteins)), is reported.
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 (show SP1 Proteins) promoter binding activity.
TLR4 (show TLR4 Proteins)-NF-kappaB (show NFKB1 Proteins) signal pathway is inhibited by paeonol in endotoxin-induced acute kidney injury
Type III secretion system of enteropathogenic Escherichia coli is necessary and sufficient for host NF-kappaB (show NFKB1 Proteins) activation.
TNF-alpha (show TNF Proteins) and the transcription factor nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)) p65 subunit were both upregulated in bleomycin-induced fibrotic lung tissue.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
this study demonstrates that phosphorylation of p65 serine 467 augment NF-kappaB (show NFKB1 Proteins) activity and exacerbates various deleterious effects of overnutrition in mice
RORalpha/gamma are important therapeutic targets for cutaneous inflammation; RORa (show RORA Proteins) and RORg (show RORC Proteins) have roles in inflammation in mouse models of atopic dermatitis and acute irritant dermititis
These findings identify differential requirements for the canonical NF-kappaB (show NFKB1 Proteins) subunits c-REL and RELA at distinct stages of mature B-cell development.
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a Rela-dependent mechanism.
p65 expression correlates with elevated total cellular levels of STAT3 (show STAT3 Proteins) and STAT1 (show STAT1 Proteins) and supports activation of these transcription factors.
Acanthopanax senticosus polysaccharide pretreatment may be associated with inhibition of the NF-kappaB (show NFKB1 Proteins)/MLCK (show MYLK Proteins) pathway and concomitant amelioration of LPS (show TLR4 Proteins)-induced tight junction dysfunction of intestinal epithelium in endotoxemia
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
C-Rel proto-oncogene protein
, oncogene REL, avian reticuloendotheliosis
, proto-oncogene c-Rel
, v-rel reticuloendotheliosis viral oncogene homolog
, NF-kappa-B p65delta3
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, C-Rel protein
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit
, reticuloendotheliosis oncogene
, v-rel avian reticuloendotheliosis viral oncogene homolog
, LOW QUALITY PROTEIN: proto-oncogene c-Rel