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Human p65 Protein expressed in HEK-293 Cells - ABIN2730698
Srinivasan, Blackburn, Lahiri: Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. in Drug design, development and therapy 2015
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Human p65 Protein expressed in Wheat germ - ABIN1317783
Ba, Bacsi, Luo, Aguilera-Aguirre, Zeng, Radak, Brasier, Boldogh: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. in Journal of immunology (Baltimore, Md. : 1950) 2014
compared with patients with NF-kappaB (show NFKB1 Proteins)-94 ins (show INS Proteins)/del ATTG ins/ins (show INS Proteins) and ins (show INS Proteins)/del, multiple myeloma patients with del/del had the highest myeloma cell ratio
The riboflavin transporter-3 (SLC52A3) 5'-flanking regions contain NF-kappaB p65/Rel-B-binding sites, which are crucial for mediating SLC52A3 transcriptional activity in esophageal squamous cell carcinoma (ESCC) cells.
Akirin-2 can be a novel biomarker in imatinib resistance. Targeting Akirin-2, NFkappaB and beta-catenin genes may provide an opportunity to overcome imatinib resistance in CML.
NF-kappaB (show NFKB1 Proteins)-94ins/del ATTG genotype might serve as a novel biomarker and potential target for immune thrombocytopenia
The results of the present study suggested that the therapeutic effect of TGP (show TGM4 Proteins) on psoriasis may be mediated by modulation of the p38 MAPK (show MAPK14 Proteins)/NFkappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) signaling pathway. The results of the present study contribute to the understanding of the role of TGP (show TGM4 Proteins) in the treatment of psoriasis. The present study provides insights suggesting that p38 MAPK (show MAPK14 Proteins) may be a novel regulatory signaling pathway for the treatment of psoriasis.
our results suggest that melatonin may exert anti-tumor activities against thyroid carcinoma by inhibition of p65 (show GORASP1 Proteins) phosphorylation and induction of reactive oxygen species. Radio-sensitization by melatonin may have clinical benefits in thyroid cancer.
The effect of lutein antiproliferation was mediated by activation of the NrF2 (show GABPA Proteins)/ARE pathway, and blocking of the NF-kappaB (show NFKB1 Proteins) signaling pathway..lutein treatment decreased NF-kappaB (show NFKB1 Proteins) signaling pathway related NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) protein expression.
Furthermore, the present study suggested that SNHG15 may be involved in the nuclear factorkappaB signaling pathway, induce the epithelialmesenchymal transition process, and promote renal cell carcinoma (show MOK Proteins) invasion and migration.
This revealed that the overexpression of p65 (show GORASP1 Proteins) partially reversed SOX4 downregulation-induced apoptosis. In conclusion, our results demonstrated that inhibition of SOX4 markedly induced melanoma cell apoptosis via downregulation of the NF-kappaB (show NFKB1 Proteins) signaling pathway, which thus may be a novel approach for the treatment of melanoma.
downregulation of HAGLROS may alleviate lipopolysaccharide-induced inflammatory injury in WI-38cells via modulating miR (show MLXIP Proteins)-100/NF-kappaB (show NFKB1 Proteins) axis.
Results showed that the secretion and expression of inflammatory cytokines increased in a dose-dependent manner in response to acetoacetate and glucose; both drugs also upregulated NF-kappa B (show NFKB1 Proteins) p65 (show SYT1 Proteins) and Ikappab-alpha (show NFKBIA Proteins) phosphorylation levels.
Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder
These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.
NF-kappaB (show NFKB1 Proteins) signaling pathway was activated by transmissible gastroenteritis virus infection.NF-kappaB has 4 binding sites in the FcRn (show FCGRT Proteins) promoter.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Proteins)/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB (show NFKB1 Proteins).
Zinc finger nuclease (show DCLRE1C Proteins) in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A (show CORO1A Proteins) is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB (show NFKB1 Proteins) p65 (show SYT1 Proteins) subunit (pp65 (show LCP1 Proteins)), is reported.
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 (show SP1 Proteins) promoter binding activity.
YY1 (show YY1 Proteins) was progressively up-regulated in BV2 microglial cells stimulated with lipopolysaccharide (LPS (show TLR4 Proteins)), which was dependent on the transactivation function of nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)). Furthermore, YY1 (show YY1 Proteins) knockdown notably inhibited LPS (show TLR4 Proteins)-induced the activation of NF-kappaB (show NFKB1 Proteins) signaling and interleukin-6 (IL-6 (show IL6 Proteins)) expression in BV-2cells.
This study reports here an X-ray crystal structure of homodimers comprising the RelA DNA-binding domain containing the Rel homology region (RHR (show ADRB1 Proteins)) in NF-kappa B (show NFKB1 Proteins) bound to an E-selectin (show SELE Proteins) promoter fragment with tandem kappa B sites.
These observations imply that pre-excision step(s) during OGG1 (show OGG1 Proteins) initiated base excision repair evoked by reactive oxygen species facilitates NF-kappaB (show NFKB1 Proteins) DNA occupancy and gene expression.
p65/NF-kappaB controls ankyrin-G levels in axon initial segment via a negative feedback loop.
This study demonstrates that the synergistic effect between TLR4 (show TLR4 Proteins) and TLR3 (show TLR3 Proteins) in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 (show TLR3 Proteins) up-regulation is dependent on TLR4 (show TLR4 Proteins)-MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling.
During skeletal development, homozygous knockout of transcription factor RelA (Rela) leads to impaired growth through ectopic apoptosis of chondrocytes, whereas heterozygous knockout of Rela does not alter growth.
NF-kappa B (show NFKB1 Proteins) p65 transcriptional activity is regulated by platelet-activating factor in macrophages.
Thalidomide potentiates etoposide-induced apoptosis in murine neuroblastoma (show ARHGEF16 Proteins) by suppressing NF-kappaB (show NFKB1 Proteins).
Pudilan xiaoyan oral liquid prevents LPS (show TLR4 Proteins)-induced respiratory in fl ammation via effects on TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling.
Catalase (show CAT Proteins) ameliorates diabetes-induced cardiomyopathy through reduced RelA-mediated transcription of BECN1 (show BECN1 Proteins).
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
C-Rel proto-oncogene protein
, oncogene REL, avian reticuloendotheliosis
, proto-oncogene c-Rel
, v-rel reticuloendotheliosis viral oncogene homolog
, NF-kappa-B p65delta3
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, C-Rel protein
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit
, reticuloendotheliosis oncogene
, v-rel avian reticuloendotheliosis viral oncogene homolog
, LOW QUALITY PROTEIN: proto-oncogene c-Rel