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Human p65 Protein expressed in HEK-293 Cells - ABIN2730698
Srinivasan, Blackburn, Lahiri: Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. in Drug design, development and therapy 2015
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Human p65 Protein expressed in Wheat germ - ABIN1317783
Ba, Bacsi, Luo, Aguilera-Aguirre, Zeng, Radak, Brasier, Boldogh: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. in Journal of immunology (Baltimore, Md. : 1950) 2014
the present result indicated that vascular smooth proliferation is regulated by activation of the NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins)/miR17/RB pathway. As NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) signalling is activated in and is a master regulator of the inflammatory response, the present findings may provide a mechanism for the excessive proliferation of VSMCs under inflammation during vascular disorders and may identify novel targets for the treatment of vascular ...
the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression
A20 (show TNFAIP3 Proteins) was significantly downregulated while p-p65 (RelA) significantly upregulated in the radioresistant nasopharyngeal carcinoma (NPC (show NPC1 Proteins))relative to radiosensitive NPCs, and miR (show MLXIP Proteins)-125b expression level was negatively associated with A20 (show TNFAIP3 Proteins) expression level, whereas positively associated with p-p65 (RelA) level
ghrelin effectively suppressed TNF-alpha-induced inflammatory factors' (including ICAM-1, VCAM-1, MCP-1, and IL-1beta) expression through inhibiting AMPK phosphorylation and p65 expression both in HUVEC and THP-1.
these data indicated that the MALAT1/miR146a/NF-kappaB (show NFKB1 Proteins) pathway exerted key functions in LPS (show IRF6 Proteins)-induced acute kidney injury (AKI), and provided novel insights into the mechanisms of this therapeutic candidate for the treatment of the disease.
Cytosolic AGR2 (show AGR2 Proteins) contributed to cell metastasis ascribed to its stabilizing effect on p65 (show GORASP1 Proteins) protein, which subsequently activated the NF-kappaB (show NFKB1 Proteins) and facilitated epithelial to mesenchymal transition (EMT (show ITK Proteins)).
we provide evidence that S100A7 (show S100A7 Proteins) also inhibits YAP (show YAP1 Proteins) expression and activity through p65 (show GORASP1 Proteins)/NFkappaB (show NFKB1 Proteins)-mediated repression of DeltaNp63, and S100A7 (show S100A7 Proteins) represses drug-induced apoptosis via inhibition of YAP (show YAP1 Proteins).
this study shows the age-related reductions in serum IL-12 (show IL12A Proteins) in healthy nonobese subjects
NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) potentiated tumor growth via suppressing a novel target LPTS (show PINX1 Proteins)
p65 siRNA retroviruses could suppress the activation of NFkappaB signal pathway.
Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder
These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Proteins)/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB (show NFKB1 Proteins).
Zinc finger nuclease (show DCLRE1C Proteins) in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A (show CORO1A Proteins) is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB (show NFKB1 Proteins) p65 (show SYT1 Proteins) subunit (pp65 (show LCP1 Proteins)), is reported.
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 (show SP1 Proteins) promoter binding activity.
Catalase (show CAT Proteins) ameliorates diabetes-induced cardiomyopathy through reduced RelA-mediated transcription of BECN1 (show BECN1 Proteins).
SOD2 (show SOD2 Proteins) expression is ATM (show ATM Proteins)- and RelA-dependent, ATM (show ATM Proteins) knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm (show ATM Proteins) fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm (show ATM Proteins) deletion significantly diminished the expression of Sod2 (show SOD2 Proteins).
RelA-BRD4 (show BRD4 Proteins) signaling in nonciliated bronchiolar epithelial cells mediates neutrophilic airway inflammation and Respiratory Syncytial disease severity.
A significant decline of p65 level was observed in the brain tissues of hamsters infected with scrapie agent 263K at terminal stage. p65 colocalized with neuronal nuclear protein positive cells but not with glial fibrillary acidic protein (show GFAP Proteins) positive cells.
EMMPRIN inhibited bFGF (show FGF2 Proteins)-induced IL-6 (show IL6 Proteins) secretion by reducing the p65 subunit phosphorylation, it might be concluded that bFGF (show FGF2 Proteins) and EMMPRIN crosstalk in their respective signaling pathways.
these findings suggest that BRD7 (show BRD7 Proteins) has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-small ka, CyrillicB signaling pathway, which provides evidence to aid in understanding the therapeutic effects of BRD7 (show BRD7 Proteins) on inflammatory diseases
NF-kappaB1 (show NFKB1 Proteins) modifies acute inflammatory renal injury but does not influence chronic fibrotic injury
beta-catenin (show CTNNB1 Proteins) and p65 are activated in separate cellular compartments during liver regeneration, with p65 activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin (show CTNNB1 Proteins), cyclin D1 (show CCND1 Proteins) expression, and subsequent proliferation
the enhancement of stat3 (show STAT3 Proteins) phosphorylation and decrease of LPS (show TLR4 Proteins)-induced p65 translocation were achieved by nicotine treatment..this study revealed that TIPE2 (show TNFAIP8L2 Proteins) upregulation and stat3 (show STAT3 Proteins) phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 (show TNFAIP8L2 Proteins) and stat3 (show STAT3 Proteins) might be potential molecules for dealing with inflammation-associated diseases.
The data demonstrate that miR (show MLXIP Proteins)-125b regulates nasopharyngeal carcinoma cell proliferation and apoptosis by targeting A20 (show TNFAIP3 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway, and miR (show MLXIP Proteins)-125b acts as oncogene (show RAB1A Proteins), whereas A20 (show TNFAIP3 Proteins) functions as tumor suppressor.
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
C-Rel proto-oncogene protein
, oncogene REL, avian reticuloendotheliosis
, proto-oncogene c-Rel
, v-rel reticuloendotheliosis viral oncogene homolog
, NF-kappa-B p65delta3
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, C-Rel protein
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit
, reticuloendotheliosis oncogene
, v-rel avian reticuloendotheliosis viral oncogene homolog
, LOW QUALITY PROTEIN: proto-oncogene c-Rel