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Human p65 Protein expressed in HEK-293 Cells - ABIN2730698
Srinivasan, Blackburn, Lahiri: Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. in Drug design, development and therapy 2015
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Human p65 Protein expressed in Wheat germ - ABIN1317783
Ba, Bacsi, Luo, Aguilera-Aguirre, Zeng, Radak, Brasier, Boldogh: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. in Journal of immunology (Baltimore, Md. : 1950) 2014
This revealed that the overexpression of p65 (show GORASP1 Proteins) partially reversed SOX4 downregulation-induced apoptosis. In conclusion, our results demonstrated that inhibition of SOX4 markedly induced melanoma cell apoptosis via downregulation of the NF-kappaB (show NFKB1 Proteins) signaling pathway, which thus may be a novel approach for the treatment of melanoma.
downregulation of HAGLROS may alleviate lipopolysaccharide-induced inflammatory injury in WI-38cells via modulating miR (show MLXIP Proteins)-100/NF-kappaB (show NFKB1 Proteins) axis.
our observations suggest that the RelA-activation domain and multiple cofactor proteins function cooperatively to prime the RelA-DNA binding domain and stabilize the RelA:DNA complex in cells
Results show that MKL1 influences the chromatin structure of pro-inflammatory genes. Specifically, MKL1 defined histone H3K4 trimethylation landscape for NF-kappaB (show NFKB1 Proteins) dependent transcription.
Studied association of SIRT2 (show SIRT2 Proteins) and p53 (show TP53 Proteins)/NF-kB p65 signal pathways in preventing high glucose-induced vascular endothelial cell injury. Results demonstrated that SIRT2 (show SIRT2 Proteins) overexpression is associated with deacetylation of p53 (show TP53 Proteins) and NF-kB p65, which inhibits the high glucose induced apoptosis and vascular endothelial cell inflammation response.
In conclusion, the spindle cell morphology should be induced by RelA activation (p-RelA S468) by IKKepsilon (show IKBKE Proteins) upregulation in human herpesvirus 8 vFLIP-expressing EA hy926 cells.
High P65 (show GORASP1 Proteins) expression is associated with doxorubicin-resistance in breast cancer.
reduced miR (show MLXIP Proteins)-138 expression enhanced the destruction of the cartilage tissues among osteoarthritis patients, mainly through targeting p65 (show GORASP1 Proteins).
the present result indicated that vascular smooth proliferation is regulated by activation of the NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins)/miR17/RB pathway. As NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) signalling is activated in and is a master regulator of the inflammatory response, the present findings may provide a mechanism for the excessive proliferation of VSMCs under inflammation during vascular disorders and may identify novel targets for the treatment of vascular ...
the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression
Results showed that the secretion and expression of inflammatory cytokines increased in a dose-dependent manner in response to acetoacetate and glucose; both drugs also upregulated NF-kappa B (show NFKB1 Proteins) p65 (show SYT1 Proteins) and Ikappab-alpha (show NFKBIA Proteins) phosphorylation levels.
Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder
These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.
NF-kappaB (show NFKB1 Proteins) signaling pathway was activated by transmissible gastroenteritis virus infection.NF-kappaB has 4 binding sites in the FcRn (show FCGRT Proteins) promoter.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Proteins)/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB (show NFKB1 Proteins).
Zinc finger nuclease (show DCLRE1C Proteins) in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A (show CORO1A Proteins) is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB (show NFKB1 Proteins) p65 (show SYT1 Proteins) subunit (pp65 (show LCP1 Proteins)), is reported.
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 (show SP1 Proteins) promoter binding activity.
This study demonstrates that the synergistic effect between TLR4 (show TLR4 Proteins) and TLR3 (show TLR3 Proteins) in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 (show TLR3 Proteins) up-regulation is dependent on TLR4 (show TLR4 Proteins)-MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling.
During skeletal development, homozygous knockout of transcription factor RelA (Rela) leads to impaired growth through ectopic apoptosis of chondrocytes, whereas heterozygous knockout of Rela does not alter growth.
NF-kappa B (show NFKB1 Proteins) p65 transcriptional activity is regulated by platelet-activating factor in macrophages.
Thalidomide potentiates etoposide-induced apoptosis in murine neuroblastoma (show ARHGEF16 Proteins) by suppressing NF-kappaB (show NFKB1 Proteins).
Pudilan xiaoyan oral liquid prevents LPS (show TLR4 Proteins)-induced respiratory in fl ammation via effects on TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling.
Catalase (show CAT Proteins) ameliorates diabetes-induced cardiomyopathy through reduced RelA-mediated transcription of BECN1 (show BECN1 Proteins).
SOD2 (show SOD2 Proteins) expression is ATM (show ATM Proteins)- and RelA-dependent, ATM (show ATM Proteins) knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm (show ATM Proteins) fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm (show ATM Proteins) deletion significantly diminished the expression of Sod2 (show SOD2 Proteins).
RelA-BRD4 (show BRD4 Proteins) signaling in nonciliated bronchiolar epithelial cells mediates neutrophilic airway inflammation and Respiratory Syncytial disease severity.
A significant decline of p65 level was observed in the brain tissues of hamsters infected with scrapie agent 263K at terminal stage. p65 colocalized with neuronal nuclear protein positive cells but not with glial fibrillary acidic protein (show GFAP Proteins) positive cells.
EMMPRIN inhibited bFGF (show FGF2 Proteins)-induced IL-6 (show IL6 Proteins) secretion by reducing the p65 subunit phosphorylation, it might be concluded that bFGF (show FGF2 Proteins) and EMMPRIN crosstalk in their respective signaling pathways.
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
C-Rel proto-oncogene protein
, oncogene REL, avian reticuloendotheliosis
, proto-oncogene c-Rel
, v-rel reticuloendotheliosis viral oncogene homolog
, NF-kappa-B p65delta3
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, C-Rel protein
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit
, reticuloendotheliosis oncogene
, v-rel avian reticuloendotheliosis viral oncogene homolog
, LOW QUALITY PROTEIN: proto-oncogene c-Rel