Browse our RIPK1 Proteins (RIPK1)

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

• receptor interacting serine/threonine kinase 1 (RIPK1)
• receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1)
• receptor interacting serine/threonine kinase 1 (Ripk1)
• receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L)

• D330015H01Rik protein
• Rinp protein
• RIP protein
• rip1 protein
• ripk1 protein
• Show all synonym aliases
• xrip1 protein
• xRIP1beta protein

RIP-1 , cell death protein RIP , receptor interacting protein , receptor-interacting protein 1 , receptor-interacting serine/threonine-protein kinase 1 , serine/threonine-protein kinase RIP , receptor (TNFRSF)-interacting serine-threonine kinase 1 , receptor interacting serine/threonine kinase 1 L homeolog , receptor-interacting protein 1 beta