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RIPK1 Proteins

(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

recommended

RIPK1 Protein (AA 1-671) (His tag) (ABIN7555218)

custom-made RIPK1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

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recommended

RIPK1 Protein (AA 1-671) (GST tag) (ABIN1318108)

RIPK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

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recommended

RIPK1 Protein (AA 1-656) (His tag) (ABIN7563883)

custom-made RIPK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

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RIPK1 Proteins by Grade

Find RIPK1 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

RIPK1 Proteins by Origin

Find RIPK1 Proteins for a variety of species such as anti-Human RIPK1, anti-Bryonia dioica (Red bryony) RIPK1, anti-Drimia maritima (Sea squill) (Charybdis maritima) RIPK1. The species listed below are among those available. Click on a link to go to the corresponding products.

RIPK1 Proteins by Source

Here you will find RIPK1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

RIPK1 Proteins by Protein Type

Here you can find RIPK1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

RIPK1 Proteins by Application

Find RIPK1 Proteins validated for a specific application such as SDS, WB, ELISA, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

RIPK1 Proteins by Biological Activity

Find RIPK1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular RIPK1 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

RIPK1 Protein (AA 1-671) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7555218

Quantity 1 mg

Datasheet Datasheet

RIPK1 Protein (AA 1-671) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1318108

Quantity 10 μg

Datasheet Datasheet

RIPK1 Protein (AA 1-656) (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7563883

Quantity 1 mg

Datasheet Datasheet

RIPK1 Protein (AA 292-438) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124799

Quantity 50 μg

Datasheet Datasheet

RIPK1 Protein (AA 562-671) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1318110

Quantity 10 μg

Datasheet Datasheet

RIPK1 Protein (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7579244

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (GST tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN5509127

Quantity 10 μg

Datasheet Datasheet

RIPK1 Protein (AA 17-289) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7407070

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (AA 1-179) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7407073

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (AA 1-671) (Strep Tag)

Reactivity Human

Source Cell-free protein synthesis (CFPS)

Validations

Cat. No. ABIN3095020

Quantity 250 μg

Datasheet Datasheet

RIPK1 Protein (AA 1-656) (Strep Tag)

Reactivity Mouse

Source Cell-free protein synthesis (CFPS)

Validations

Cat. No. ABIN3135313

Quantity 250 μg

Datasheet Datasheet

RIPK1 Protein (AA 1-257, full length) (His tag)

Reactivity Drimia maritima (Sea squill) (Charybdis maritima)

Source Yeast

Validations

Cat. No. ABIN5713982

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (AA 24-269) (His tag)

Reactivity Momordica charantia (Bitter gourd) (Balsam pear)

Source Yeast

Validations

Cat. No. ABIN5714046

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (AA 24-247) (His tag)

Reactivity Bryonia dioica (Red bryony)

Source Yeast

Validations

Cat. No. ABIN5714110

Quantity 100 μg

Datasheet Datasheet

RIPK1 Protein (AA 24-247, partial) (His-SUMO Tag)

Reactivity Bryonia dioica (Red bryony)

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN5710918

Quantity 100 μg

Datasheet Datasheet

Latest Publications for our RIPK1 Proteins

Boutaffala, Bertrand, Remouchamps, Seleznik, Reisinger, Janas, Bénézech, Fernandes, Marchetti, Mair, Ganeff, Hupalowska, Ricci, Becher, Piette, Knolle, Caamano, Vandenabeele, Heikenwalder, Dejardin: "NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis." in: Cell death and differentiation, Vol. 22, Issue 12, pp. 2020-33, (2015) (PubMed).

Fuller, Osborne, Leonard, Hardyman, Vaniotis, Allen, Sugden, Clerk: "Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts." in: Cardiovascular research, Vol. 108, Issue 1, pp. 87-98, (2015) (PubMed).

Aliases for RIPK1 Proteins

receptor interacting serine/threonine kinase 1 (RIPK1) Proteins
receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) Proteins
receptor interacting serine/threonine kinase 1 (Ripk1) Proteins
receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L) Proteins
D330015H01Rik Proteins
Rinp Proteins
RIP Proteins
RIP1 Proteins
Rip1 Proteins
rip1 Proteins
ripk1 Proteins
xrip1 Proteins
xRIP1beta Proteins

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RIPK1 Proteins by Grade

RIPK1 Proteins by Origin

RIPK1 Proteins by Source

RIPK1 Proteins by Protein Type

RIPK1 Proteins by Application

RIPK1 Proteins by Biological Activity

Popular RIPK1 Proteins

Latest Publications for our RIPK1 Proteins

Aliases for RIPK1 Proteins

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