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We show here that both molecules (Deltex (DTX) and AIP4) interact and partially colocalize to endocytic vesicles, and that AIP4 targets DTX for lysosomal degradation.
It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003
deltex 3 homolog
, protein deltex-3
, deltex 3-like protein
, deltex homolog 3 (Drosophila)
, probable E3 ubiquitin-protein ligase DTX3
, RING finger protein 154
, Protein deltex-3