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Full name:: Serrate RNA Effector Molecule Homolog (Arabidopsis) Proteins (SRRT)

On www.antibodies-online.com are 5 Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) Proteins from 4 different suppliers available. Additionally we are shipping SRRT Antibodies (35) and many more products for this protein. A total of 45 SRRT products are currently listed.

Synonyms:: 2810019G02Rik, anon-WO0118547.166, Ars2, ars2-A, Asr2, ASR2A, ASR2B, ASR2C, ASR2D, CG7843, CHUNP6881, Dmel\\CG7843, MGC92060, serrate, zgc:92060

list all proteins	Gene Name	GeneID	UniProt
	SRRT	51593	Q9BXP5
	SRRT	83701	Q99MR6
	SRRT
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Fruit Fly (Drosophila melanogaster) Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

Study identified Ars2 as a key component of Drosophila antiviral immunityp; loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses.

Human Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci.
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 (show HMOX1 Proteins) and ARS2 expression by inhibiting Nrf2 (show GABPA Proteins), NF-kappaB (show NFKB1 Proteins), AP-1 (show FOSB Proteins) and MAPK (show MAPK1 Proteins) pathways in human proximal tubular cells.
Ars2 is overexpressed in HCC (show FAM126A Proteins) and may have prognostic value; it might play an important role in HCC (show FAM126A Proteins) proliferation and miR (show MLXIP Proteins)-21 expression.
ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis.
Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 (show PDCD4 Proteins) protein levels via the reduction of miR (show MLXIP Proteins)-21.
Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA.
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
Results suggest that FLASH functions in S phase progression through interaction with ARS2.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2).

Mouse (Murine) Serrate RNA Effector Molecule Homolog (Arabidopsis) (SRRT) interaction partners

ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2 (show SOX2 Proteins)
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.

SRRT Protein Profile

Protein Summary

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA)\; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Alternative names and synonyms associated with SRRT

Arsenic resistance protein 2 (Ars2)
serrate, RNA effector molecule S homeolog (srrt.S)
serrate, RNA effector molecule (SRRT)
serrate RNA effector molecule homolog (Arabidopsis) (Srrt)
serrate, RNA effector molecule (Srrt)
serrate RNA effector molecule homolog (Arabidopsis) (srrt)

2810019G02Rik protein
anon-WO0118547.166 protein
Ars2 protein
ars2-A protein
Asr2 protein
ASR2A protein
ASR2B protein
ASR2C protein
ASR2D protein
CG7843 protein
CHUNP6881 protein
Dmel\\CG7843 protein
MGC92060 protein
serrate protein
zgc:92060 protein

Protein level used designations for SRRT

, , , , , , , , , , , , , , , , , , , Ars2-PA Ars2-PC Ars2-PD Ars2-PE Ars2-PF Ars2-PG CG7843-PA CG7843-PC CG7843-PD CG7843-PE CG7843-PF CG7843-PG Arsenite-resistance protein 2-A serrate RNA effector molecule homolog A arsenate resistance protein 2 arsenate resistance protein ARS2 arsenite resistance protein arsenite-resistance protein 2 serrate RNA effector molecule homolog Arsenite-resistance protein 2

GENE ID	SPECIES
35539	Drosophila melanogaster
100037061	Xenopus laevis
51593	Homo sapiens
83701	Mus musculus
527938	Bos taurus
100689205	Cricetulus griseus
192311	Danio rerio

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