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anti-Human FOXL2 Antibodies:
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Human Polyclonal FOXL2 Primary Antibody for ChIP, ELISA - ABIN249959
Jamieson, Butzow, Andersson, Alexiadis, Unkila-Kallio, Heikinheimo, Fuller, Anttonen: The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010
Show all 29 Pubmed References
Human Polyclonal FOXL2 Primary Antibody for IHC, ELISA - ABIN185040
Crisponi, Deiana, Loi, Chiappe, Uda, Amati, Bisceglia, Zelante, Nagaraja, Porcu, Ristaldi, Marzella, Rocchi, Nicolino, Lienhardt-Roussie, Nivelon, Verloes, Schlessinger, Gasparini, Bonneau, Cao, Pilia: The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. in Nature genetics 2001
Show all 3 Pubmed References
Human Polyclonal FOXL2 Primary Antibody for IF (p), IHC (p) - ABIN1715065
Cai, Sun, Li, Tsinkgou, Yu, Ying, Chen, Shi: Molecular mechanisms of enhancing porcine granulosa cell proliferation and function by treatment in vitro with anti-inhibin alpha subunit antibody. in Reproductive biology and endocrinology : RB&E 2015
Cow (Bovine) Polyclonal FOXL2 Primary Antibody for WB - ABIN2777885
Tang, Wang, Lin, Sun, Wang, Yu: Mutation analysis of the FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome. in Mutagenesis 2006
Human Polyclonal FOXL2 Primary Antibody for FACS, WB - ABIN654125
Nakashima, Chung, Takahashi, Kamatani, Kawaguchi, Tsunoda, Hosono, Kubo, Nakamura, Zembutsu: A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. in Nature genetics 2010
Show all 3 Pubmed References
Cow (Bovine) Polyclonal FOXL2 Primary Antibody for WB - ABIN610539
Ayllón, Cayla, García, Roncal, Fernández, Albar, Martínez, Rebollo: Bcl-2 targets protein phosphatase 1 alpha to Bad. in Journal of immunology (Baltimore, Md. : 1950) 2001
In the present study, we analysed two Han Chinese families with BPES type I and identified two novel mutations (c.462_468del and c.988_989insG). Immunofluorescence and confocal microscopy revealed that the extended FOXL2, p.Ala330Glyfs*204, induced significant mislocalization and aggregation.
Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 (show MYH6 Antibodies) gene variant, and the 71098693 HYDIN (show HYDIN Antibodies) gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 (show MYH6 Antibodies) were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4).
We describe a girl and her father with isolated BPES without an intragenic mutation in FOXL2. MLPA of a FOXL2 enhancer region identified a small microdeletion at 234 kb upstream of FOXL2. This deletion fully includes the PISRT1 gene, a noncoding gene which is part of a cis (show CISH Antibodies)-regulatory element of FOXL2
MiR (show MLXIP Antibodies)-937 inhibits the proliferation and metastasis of gastric cancer cells by targeting FOXL2 via inactivation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway. These results suggest that miR (show MLXIP Antibodies)-937 may be a potential target for the treatment of gastric cancer.
This study demonstrated the existence of an AMH (show AMH Antibodies)-FOXL2 relationship in hGCs. AMH (show AMH Antibodies) is capable of increasing both gene and protein expression of FOXL2. Because FOXL2 induces AMH (show AMH Antibodies) transcription, these ovarian factors could be finely regulated by a positive feedback loop mechanism to preserve the ovarian follicle reserve.
A novel FOXL2 indel mutation was identified in Chinese families with BPES. Our results expand the spectrum of known FOXL2 mutations and provide additional insight into the structure-function relationships of the FOXL2 protein.
The adult granulosa cell tumor (AGCT)-like components are likely to be tumor-like proliferations but not truly neoplastic AGCT. FOXL2 mutation testing may be useful in confirming an AGCT-like component.
This novel duplicate mutation (c.844_860dup17, p.His291Argfs*71) in FOXL2 was identified in a Chinese family with both types of BPES. These findings expand current knowledge of the mutation spectrum of the FOXL2 gene and confirmed the intrafamily phenotypic heterogeneity of BPES.
The study shows that half of granulosa theca cell tumors harbor the same FOXL2 mutation that characterizes adult granulosa cell tumors but there is no outcome evidence to guide whether mutation status should alter the classification of the tumor or the management of the patient.
The promoter of FOXL2 was successfully cloned and registered in Gen (show GEN1 Antibodies) Bank, and a dual luciferase reporter (DLR) analysis demonstrated that the luciferase activity was significantly induced by the promoter of FOXL2. Subsequently, bioinformatics analysis indicated that FOXL2 may be regulated by STAT3 (show STAT3 Antibodies).
We found that endometrial cells expressing low FOXL2 levels, either endogenous or genetically manipulated, were associated with a higher attachment rate of mouse blastocysts. low-FOXL2 levels were associated with changes in the expression level of components of the Wnt (show WNT2 Antibodies)/Fzd and apoptotic pathways, both of which are involved in uterine receptivity.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (show WNT4 Antibodies)- and FOXL2-driven ovarian-determining pathways.
direct overexpression of Foxl2 decreased the expression of Sertoli cell-specific genes in primary Sertoli cells. Taken together, these results demonstrate that repression of beta-catenin (CTNNB1 (show CTNNB1 Antibodies)) signaling is required for lineage maintenance of Sertoli cells.
evidence that FOXL2 modulates Col1a2 (show COL1A2 Antibodies) transcription through interaction with a response element 65 Kb upstream of the transcription start site
Data indicate that a balance between supporting cell (show PTPRJ Antibodies) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 (show WNT4 Antibodies) protein/beta-catenin (show CTNNB1 Antibodies) and p27Kip1 (show CDKN1B Antibodies) protein (p27 (show CDKN1B Antibodies))/Forkhead box L2 (FOXL2) activities.
Data indicate that the hypothalamic-pituitary-gonadal axis controls expression of Foxl2 in pituitary gonadotropes primarily through positive feedback from ovarian hormones.
FOXL2 mobilizes estrogen signaling to establish a coherent feed-forward loop repressing Sox9 (show SOX9 Antibodies).
Foxl2 has a crucial role in postnatal uterine maturation and could help to understand sub-fertility predisposition in women.
Results support FOXL2 as a master transcription factor in a spectrum of developmental processes, including growth, cartilage and bone formation. Its action overlaps that of SOX9 (show SOX9 Antibodies), though they are antagonistic in female vs male gonadal sex determination but conjoint in cartilage and skeletal development.
Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 (show INSL3 Antibodies) in GDX (show UBL4A Antibodies)-induced adrenocortical tumors of the mouse.
In vivo and in vitro experiments highlighted that neither interferon-tau nor FOXL2 were involved in transcriptional regulation of CAT, SOD1 (show SOD1 Antibodies) and SOD2 (show SOD2 Antibodies)
Data show that cytochrome P450 (show CYP Antibodies) enzymes Cyp17 (show CYP17A1 Antibodies)-I, Cyp11c1 (show CYP11B2 Antibodies), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Antibodies) Foxl2a were detected both in the testis and ovary.
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus
Xenopus W-linked DM-W induces foxl2 expression during ovary formation.
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.
forkhead box protein L2
, forkhead transcription factor FOXL2
, pituitary forkhead factor
, putative transcription factor foxl2
, forkhead transcription factor L2
, forkhead box L2
, transcription factor FOXL2
, foxl2 protein
, fork-head box L2 transcription factor
, Forkhead box protein L2