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Human HMGA1 Protein expressed in Wheat germ - ABIN1306792
Lau, Chan, Pang, Ma, Li, Yeung, Cheng, Feng, Chung, Li, Zhou, Wang, Mao, Ng: Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma. in Acta neuropathologica 2012
Studies define a novel HMGA1-MMP-2 (show MMP2 Proteins) pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.
Mouse embryonic fibroblasts null for the Hmga1 gene show downregulation of Bub1 (show BUB1 Proteins), Bub1b (show BUB1B Proteins), Mad2l1 (show MAD2L1 Proteins) and Ttk SAC (show ADCY10 Proteins) genes, and present several features of chromosomal instability, such as nuclear abnormalities, binucleation, micronuclei and karyotypic alterations.
Taken together, our data demonstrate that miR (show MLXIP Proteins)-625 suppresses cell proliferation and migration by targeting HMGA1 and suggest miR (show MLXIP Proteins)-625 as a promising prognostic biomarker and a potential therapeutic target for breast cancer.
Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis.
Increased HMGA1 expression is associated with pituitary and thyroid tumors.
activated HMGA1 regulates cell proliferation through the Notch1 (show NOTCH1 Proteins) signaling pathway, which represents an important molecular pathway leading to leukemogenesis.
Data propose that, by affecting the expression of both IGFBP protein species, HMGA1 can serve as a modulator of IGF-I (show IGF1 Proteins) activity, thus representing an important novel mediator of glucose disposal.
HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.
Elevated expression of HMGA1 is associated with the transition of prostate cancer (PCa (show ENPP1 Proteins)) cells from androgen-sensitive to androgen-independent growth and plays a role in the cell growth of androgen-independent PCa (show ENPP1 Proteins) cells.
The data in the present study reveal a role of Hmga1 in transcriptional silencing in T cell lineages and leukemic cells.
IL-24 (show IL24 Proteins) inhibits AKT (show AKT1 Proteins) via regulating the HMGA1/miR (show MLXIP Proteins)-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor.
These data reveal an essential role for the molecular chaperone (show HSP90AA1 Proteins) GRP78 (show HSPA5 Proteins) in IGF-IR signaling and implicate the use of GRP78 (show HSPA5 Proteins) inhibitors in blocking IGF-IR signaling in hepatoma cells.
HMGA1 and MMP-11 (show MMP11 Proteins) may play a key role in the proliferation and progression of skin tumors in humans.
HMGA1 overexpression in adherent A2780 cells increased cancer stem cell properties, including proliferation, spheroid-forming efficiency and the expression of stemness-related genes. In addition, HMGA1 regulated ABCG2 promoter activity through HMGA1-binding sites.
Studies indicate that pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression.
study revealed a subset of potential development-associated miRNAs and suggests a novel regulatory axis for myogenesis in which miR (show MLXIP Proteins)-195/497 promote myogenic differentiation by repressing the HMGA1-Id3 (show ID3 Proteins) pathway.
Findings demonstrate that a relationship exists between the HMGA1 rs146052672 variant and acute myocardial infarction, suggesting that defects at the HMGA1 locus may play a pathogenetic role.
SNP rs5498 in ICAM-1 (show ICAM1 Proteins) gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
We show that the chromatin remodeling protein HMGA1 functions as a downstream effector of these biological responses to miR (show MLXIP Proteins)-296-5p and regulates Sox2 (show SOX2 Proteins) expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 (show SOX2 Proteins) promoter
tissue microarray revealed that HMGA1 was expressed in thyroid carcinoma more than that in normal thyroid tissues ; expression of HMGA1 and MMP-2 (show MMP2 Proteins) was identified to be positively correlated . The present study established the first link between HMGA1 and TGF-b1 in the regulation of thyroid cancer proliferation and invasion
distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 (show PLAG1 Proteins) as strong candidate genes on SSC7 and SSC4, respectively.
Characterization of polymorphisms in the HMGA1 gene in relation to growth and fat deposition.
Small interfering RNAs (siRNAs) that specifically target HMGA1 reduced HMGA1 RNA levels and bovine herpesvirus 1 production confirming HMGA1 stimulates productive infection.
HMGA1 likely regulates certain aspects of the BoHV-1 latency-reactivation cycle.
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
, high mobility group protein A1
, high mobility group protein HMG-I/HMG-Y
, high mobility group protein R
, high-mobility group (nonhistone chromosomal) protein isoforms I and Y
, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
, high mobility group AT-hook protein 1
, high-mobility group AT-hook 1
, high mobility group AT-hook 1
, high mobility group HMGA1A
, high mobility group HMGA1B
, non-histone protein
, high mobility group protein I
, High mobility group AT-hook protein 1
, High mobility group protein A1
, high mobility group-I protein