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Human Polyclonal NR1H3 Primary Antibody for GS, ICC - ABIN4331875
DiBlasio-Smith, Arai, Quinet, Evans, Kornaga, Basso, Chen, Feingold, Halpern, Liu, Nambi, Savio, Wang, Mounts, Isler, Slager, Burczynski, Dorner, LaVallie: Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. in Journal of translational medicine 2008
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Human Polyclonal NR1H3 Primary Antibody for WB - ABIN542003
Joseph, Castrillo, Laffitte, Mangelsdorf, Tontonoz: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. in Nature medicine 2003
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Polyclonal NR1H3 Primary Antibody for WB - ABIN540837
Zhang, Yin, Liao, Huang, Tang, Tsutsumi, Wang, Liu, Li, Hou, Cai, Xiao: NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. in Journal of lipid research 2006
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Human Polyclonal NR1H3 Primary Antibody for WB - ABIN5518655
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
Cow (Bovine) Polyclonal NR1H3 Primary Antibody for WB - ABIN2780709
Torra, Ismaili, Feig, Xu, Cavasotto, Pancratov, Rogatsky, Neubert, Fisher, Garabedian: Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. in Molecular and cellular biology 2008
Human Polyclonal NR1H3 Primary Antibody for ELISA, ICC - ABIN4331876
Ahn, Jang, Jun, Lee, Shin: Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. in Digestive diseases and sciences 2014
Human Polyclonal NR1H3 Primary Antibody for ELISA, WB - ABIN547351
Tangirala, Bischoff, Joseph, Wagner, Walczak, Laffitte, Daige, Thomas, Heyman, Mangelsdorf, Wang, Lusis, Tontonoz, Schulman: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2002
Human Monoclonal NR1H3 Primary Antibody for ELISA, WB - ABIN523441
Ishibashi, Filomenko, Rébé, Chevriaux, Varin, Derangère, Bessède, Gambert, Lagrost, Masson: Knock-down of the oxysterol receptor LXR? impairs cholesterol efflux in human primary macrophages: lack of compensation by LXR? activation. in Biochemical pharmacology 2013
Human Polyclonal NR1H3 Primary Antibody for ChIPSeq, ChIP - ABIN2668708
Kemmerer, Wittig, Richter, Brüne, Namgaladze: AMPK activates LXRα and ABCA1 expression in human macrophages. in The international journal of biochemistry & cell biology 2016
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
The authors report that, in Mycobacterium tuberculosis-infected macrophages, IL-36 signaling modulates cholesterol biosynthesis and efflux via LXR.
LXR-alpha played a central role in down-regulating of ABCA1 and ABCG1 and lipid accumulation induced by homocysteine in the macrophages.
LXRalpha interacts with OGT in its N-terminal domain and ligand-binding domain (LBD) in a ligand-independent fashion.
Our data suggest that LXR could be used as a biomarker for hepatocellular carcinoma prognosis.
PBMCs from healthy persons were predisposed to the MPhi2 differentiation phenotype, which exhibits elevated cholesterol uptake and anti-inflammatory properties. LXRalpha over-expression polarizes macrophages towards the anti-inflammatory MPhi2 phenotype.
LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels.
In conclusion, the present study demonstrated that activation of LXRalpha-ABCA1 axis with a synthetic LXR agonist TO90 exerted a potent protective effect against Abeta induced senescent and inflammatory responses in retinal pigment epithelial cells, suggesting that LXR agonists may be promising therapeutic agents for treating age-related macular degeneration.
AMPK activates LXRalpha and ABCA1 expression in human macrophages
PPARalpha and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR stimulation also reduces Akt phosphorylation and its localization at the plasma membrane
The effects of LXR agonist on interleukin-8 (IL-8) secretion and nuclear factor-kappa B (NF-kappaB) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Collectively, these findings demonstrate that LXRalpha activation induces 17beta-HSD13 expression in a SREBP-1c-dependent manner.
mutant NR1H3 (LXRA) alters gene expression profiles, suggesting a disruption in transcriptional regulation as one of the mechanisms underlying Multiple Sclerosis pathogenesis.
Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta, IL-6 and TNFalpha mRNA degradation, destabilized TNFalpha mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP).
It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16.
findings demonstrate that LXRalpha phosphorylation at S196 is an important determinant of atherosclerotic plaque development through selective changes in gene transcription that affect multiple pathways
FXR signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
the activation of LXRs protected rd1 mouse retina and rescued visual function by suppressing the immune inflammation mediated by JAK3-STAT pathway. LXRs agonist might become new therapeutic agents for RP.
The LXR agonist TO901317 had potent antioxidant, anti-inflammatory, and antiapoptotic effects against PQ-induced Acute Lung Injury
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts, thereby attenuating LPS mediated inflammatory response
The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
the agonists inhibited the priming of inflammasome activation. In vivo data also showed that LXRs agonist prevented NLRP3-dependent peritonitis. In conclusion, LXRs agonists are identified to potently suppress NLRP3 inflammasome and the regulation of LXRs signaling is a potential therapeutic for inflammasome-driven diseases.
LXR activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising PPARgamma-mediated transcriptional activity, which contributes to decreased insulin sensitivity in whole body.
The present study indicates a requirement for C/EBPbeta in the insulin-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c expression.
involved in the renal expression of lipogenic enzymes
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR-ABCA1/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL-C levels observed in patients receiving both medications
We describe a molecular pathway comprising miR-155 and its epigenetic LXRalpha target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for idiopathic pulmonary fibrosis.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
within the CNS, each LXR isoform differentially influences myelin gene mRNA levels in a region- and age-dependant manner, participating in the fine regulation of myelin gene expression
EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.
role in transcriptional regulation of lipid synthesis in a mammary epithelial cell line
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha