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Human Polyclonal NR1H3 Primary Antibody for GS, ICC - ABIN4331875
DiBlasio-Smith, Arai, Quinet, Evans, Kornaga, Basso, Chen, Feingold, Halpern, Liu, Nambi, Savio, Wang, Mounts, Isler, Slager, Burczynski, Dorner, LaVallie: Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. in Journal of translational medicine 2008
Show all 4 Pubmed References
Human Monoclonal NR1H3 Primary Antibody for ELISA, WB - ABIN523441
Ishibashi, Filomenko, Rébé, Chevriaux, Varin, Derangère, Bessède, Gambert, Lagrost, Masson: Knock-down of the oxysterol receptor LXR? impairs cholesterol efflux in human primary macrophages: lack of compensation by LXR? activation. in Biochemical pharmacology 2013
Human Polyclonal NR1H3 Primary Antibody for ELISA, ICC - ABIN4331876
Ahn, Jang, Jun, Lee, Shin: Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. in Digestive diseases and sciences 2014
Human Polyclonal NR1H3 Primary Antibody for ChIPSeq, ChIP - ABIN2668708
Kemmerer, Wittig, Richter, Brüne, Namgaladze: AMPK activates LXRα and ABCA1 expression in human macrophages. in The international journal of biochemistry & cell biology 2016
Cow (Bovine) Polyclonal NR1H3 Primary Antibody for WB - ABIN2780709
Torra, Ismaili, Feig, Xu, Cavasotto, Pancratov, Rogatsky, Neubert, Fisher, Garabedian: Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. in Molecular and cellular biology 2008
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
AMPK (show PRKAA1 Antibodies) activates LXRalpha and ABCA1 (show ABCA1 Antibodies) expression in human macrophages
PPARalpha (show PPARA Antibodies) and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Antibodies) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (show NR1H2 Antibodies) (LXRbeta (show NR1H2 Antibodies)) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (show NFKB1 Antibodies)) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 (show FLOT2 Antibodies) and DHHC5 (show ZDHHC5 Antibodies) in MCF-7 cells. LXR stimulation also reduces Akt (show AKT1 Antibodies) phosphorylation and its localization at the plasma membrane
The effects of LXR agonist on interleukin-8 (IL-8 (show IL8 Antibodies)) secretion and nuclear factor-kappa B (NF-kappaB (show NFKB1 Antibodies)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 (show TLR4 Antibodies) to lipid rafts, thereby attenuating LPS (show TLR4 Antibodies) mediated inflammatory response
The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
the agonists inhibited the priming of inflammasome activation. In vivo data also showed that LXRs agonist prevented NLRP3 (show NLRP3 Antibodies)-dependent peritonitis. In conclusion, LXRs agonists are identified to potently suppress NLRP3 (show NLRP3 Antibodies) inflammasome and the regulation of LXRs signaling is a potential therapeutic for inflammasome-driven diseases.
Data indicate a functional circuit linking PTEN (show PTEN Antibodies) and LXRs, and highlights LXRs as metabolic gatekeepers that are able to constrain prostate cancer (PCa (show ENPP1 Antibodies)) progression.
LXR activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising PPARgamma (show PPARG Antibodies)-mediated transcriptional activity, which contributes to decreased insulin (show INS Antibodies) sensitivity in whole body.
The present study indicates a requirement for C/EBPbeta (show CEBPB Antibodies) in the insulin (show INS Antibodies)-mediated induction of SREBP-1c (show SREBF1 Antibodies) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 (show SREBF2 Antibodies) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c (show SREBF1 Antibodies) expression.
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Antibodies)), Fatty acid synthase (FASN (show FASN Antibodies)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Antibodies) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha