Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human NRBF2 Antibodies:
anti-Mouse (Murine) NRBF2 Antibodies:
anti-Rat (Rattus) NRBF2 Antibodies:
Go to our pre-filtered search.
Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34 (show PIK3C3 Antibodies)-Vps30/Atg6 (show BECN1 Antibodies)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34 (show PIK3C3 Antibodies)-BECN1/Beclin 1 (show BECN1 Antibodies)-ATG14 (human), were characterized.
Polymorphisms in a putative enhancer at the 10q21.2 Breast Cancer Risk Locus regulate NRBF2 expression, implicating this gene in the etiology of breast cancer.
Nrbf2 may interact with the Atg14L-containing Beclin 1 (show BECN1 Antibodies)-Vps34 (show PIK3C3 Antibodies) protein complex to modulate protein-protein interactions within the complex.
NRBF2 regulates macroautophagy as a component of Vps34 (show PIK3C3 Antibodies) Complex I.
The activation domain, their small size (COPR1, 26.9 kDa; COPR2, 32.4 kDa), and strict dependence on AF-2 for interaction distinguish COPR1 and COPR2 from the SMRT/NCoR (show NCOR1 Antibodies) type of corepressor and may dampen rather than repress NR-mediated gene expression.
These data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction.
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
comodulator of PPAR and RXR 1
, comodulator of PPAR and RXR 2
, nuclear receptor binding factor-2
, nuclear receptor-binding factor 2