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Results show that NRIP2 regulates the activity of the Wnt pathway via RORbeta. RORbeta inhibits tumorigenesis and the self-renewal of cancer initiating cells (CCICs) and targets HBP1 in regulating Wnt pathway to inhibit tumorigenesis and the self-renewal of CCICs.
Nonsense variant in RORB was identified in four family members with epilepsy. Two de novo RORB deletions identified in patients with behavioral and cognitive impairment and epilepsy.
associations between NR1D1, RORA and RORB genes and bipolar disorder.(
Retinoic acid-related orphan receptor RORbeta, circadian rhythm abnormalities and tumorigenesis
these data demonstrate that Rorbeta regulates known osteogenic pathways, and may represent a novel therapeutic target for age-associated bone loss.
In the suprachiasmatic nucleus, ROR beta mRNA signals showed a peak at early daytime and a trough at early nighttime. ROR beta is a transcription factor possibly related to the circadian pacemaking system.
results suggest that a mutually repressive mechanism exists between Brn1/2 and Rorb expression and that the established expression of Brn1/2 and Rorb further specifies those neurons into L2/3 and L4, respectively, during UCP maturation
Data indicate that positive feedback between neural retina leucine zipper factor (NRL) and retinoid-related orphan receptor beta gene (Rorb) genes reinforces the commitment to a rod differentiation fate.
A distinct retinoid-related orphan nuclear receptor beta1 (RORbeta1) isoform encoded by the retinoid-related orphan nuclear receptor beta gene (Rorb) is critical for both amacrine and horizontal cell differentiation in mice.
RORbeta expression levels control cytoarchitectural patterning of neocortical neurons during development
Rorbeta iss a novel regulator of osteogenesis.
Opn1sw is a target gene for RORbeta and suggest a key role for RORbeta in regulating opsin expression in the color visual system.
We conclude that the RORbeta nuclear receptor is not involved in either the rhythmic production of pineal melatonin or in mediating phase shifts of circadian rhythms by melatonin, but it may regulate clock responses to photic stimuli.
Rorb directs rod development and does so at least in part by inducing the Nrl-mediated pathway of rod differentiation.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.
nuclear orphan receptor ROR-beta
, nuclear receptor ROR-beta
, RAR-related orphan receptor B
, retinoid-related orphan receptor beta
, nuclear receptor ROR-beta-like
, RAR-related orphan receptor beta
, nuclear receptor RZR-beta
, nuclear receptor subfamily 1 group F member 2
, retinoic acid-binding receptor beta
, retinoid-related orphan receptor-beta
, transcription factor
, retinoid-related orphan receptor b
, ror beta