Browse our anti-Splicing Factor 1 (SF1) Antibodies

Human Splicing Factor 1 (SF1) interaction partners

1. SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA

2. A novel function of SF1 in the initial recruitment of the U2 snRNP through direct interactions with two U2 snRNP-associated proteins.

3. Data suggest that post-translational processing of SF1 (phosphorylation of Ser20) down-regulates nuclear import of SF1 via alterations in kinetic interaction of SF1 nuclear localization signal (NLS) with NLS receptor isoforms.

4. We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65

5. Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies.

6. The conserved SPSP motif phosphorylation and the SF1/U2AF interface are essential in vivo.

7. Findings suggest that Zinc finger motif-1 (ZFM1) is an important factor for the stabilization of a contractile SMC phenotype under basal or mildly activating conditions.

8. central ;mystery' domain of SF1 crystals belonged to space group C2 and have most probable solvent contents of 64, 52 or 39% with three, four or five molecules per asymmetric unit, respectively

9. SF1 silencing affected alternative splicing of endogenous transcripts, establishing a previously unexpected role for SF1 and branch site-like sequences in splice site selection.

10. the conformational changes that are induced by assembly of the SF1/U2AF(65)/RNA complex serve to position the pre-mRNA splice site optimally for subsequent stages of splicing.

11. SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing

12. SF1 was essential for the induction of alternative mRNA splicing by the beta-catenin/TCF4 complex.

13. SF1 and U2AF form extraspliceosomal complexes before and after taking part in the assembly of catalytic spliceosomes.

14. Puf60-UHM binds to ULM sequences in the splicing factors SF1, U2AF65, and SF3b155.

15. The KH-QUA2 region of SF1 defines an enlarged KH (hn RNP K) fold which is necessary and sufficient for intron branched point sequence (BPS) binding.

Mouse (Murine) Splicing Factor 1 (SF1) interaction partners

1. SF1 directly contributes to the abnormal uterine gland morphogenesis.

2. Sf1 SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone)

3. we found that KLF6 transcriptionally cooperates with NUR77 and SF1

4. SF1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity.

5. Data suggest that Sf1 and c-jun interact and cooperate to activate the Fdx1 promoter in MA-10 (tumorigenic cell line) and TM3 (non-tumorigenic cell line) Leydig cells; such activation requires different regulatory elements located between -124 and -306 bp of Fdx1 promoter and involves recruitment of Sf1 to this region. (Sf1 = splicing factor 1; c-jun = proto-oncogene c-jun; Fdx1 = ferredoxin 1)

6. The results of the current study show that EB treatment from P25 to P36 could not restore the number of kisspeptin-ir cells in the AVPV in agonadal SF-1 KO mice to numbers found in gonadally intact WT or EB-treated WT/OVX females

7. the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression.

8. Results clearly indicate that SF-1 is involved in the regulation of LIPE expression after activation of protein kinase A in adrenocortical cells.

9. SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development.

10. SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.

11. Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1.

12. Crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.

13. Data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis.

14. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis indicates the involvement of SF1 in the beta-catenin-mediated regulation of proliferation.

Fruit Fly (Drosophila melanogaster) Splicing Factor 1 (SF1) interaction partners

1. The studies performed did not confirm the ability of the SF1 insulator to protect expression of reporter gene white from the chromosome position effect in transgenic lines.

Arabidopsis thaliana Splicing Factor 1 (SF1) interaction partners

1. RRM domain of Arabidopsis splicing factor SF1 is important for pre-mRNA splicing of a specific set of genes

2. The Arabidopsis splicing factors, AtU2AF65, AtU2AF35, and AtSF1 shuttle between nuclei and cytoplasms

3. Data indicate that the mutant allele of AtSF1 (At5g51300) containing a T-DNA insertion conferred pleiotropic developmental defects, including early flowering and abnormal sensitivity to abscisic acid.